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Method for preparing calcium phosphate cement/chitosan-gelatine composite porous holder

A technology of calcium phosphate bone cement and porous scaffold, applied in bone implants, medical science, prostheses, etc., can solve the problems of irregular hole shape, particle residue, poor connectivity between holes, etc., and achieve a good combination effect

Inactive Publication Date: 2008-02-20
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The particle leaching method is simple in principle and easy to operate. The porosity and pore size can be adjusted by changing the percentage of porogen and the particle size. However, the shape of the pores obtained by this method is irregular, the connectivity between the pores is poor, and there are particle residue

Method used

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  • Method for preparing calcium phosphate cement/chitosan-gelatine composite porous holder

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Calcium phosphate bone cement solid-phase powder was obtained by grinding 6.3 g of α-tricalcium phosphate with a particle size of 6.34 μm, 1.0 g of calcium dihydrogen phosphate monohydrate, 0.85 g of hydroxyapatite, and 1.85 g of calcium carbonate. The disodium hydrogen phosphate solution with a mass concentration of 0% is used as the solidification solution. Pour 1g of calcium phosphate bone cement solid phase powder into a clean crucible, take 0.9ml of solidified liquid water and add it to the calcium phosphate bone cement solid phase powder at room temperature, stir quickly with a medicine spoon, and then fill the paste into the mold Inside, squeeze out as much gas as possible. Put the mold containing the sample in a vacuum bottle and evacuate to 0.01MPa, then place the sealed vacuum bottle in a 60°C oven for foaming and curing for 2 hours, take out the mold, demould the sample, and place it at 37°C and 100% relative humidity After fully curing for 72 hours, the cal...

Embodiment 2

[0023] The experimental conditions and process of the present embodiment are the same as in Example 1, except that the mass concentration of the chitosan-gelatin solution adopted has been changed, and the chitosan-gelatin solution of 3% mass concentration is prepared, wherein the chitosan consumption is 0.27 g. The dosage of gelatin is 0.63g, and the dosage of glutaraldehyde solution containing 0.25% in mass concentration is 3mL. Then calcium phosphate bone cement porous scaffold is added in this chitosan-gelatin solution, the porosity of calcium phosphate bone cement / chitosan-gelatin composite porous scaffold obtained in the present embodiment is 66%, and compressive strength is 1.7MPa, The compressive modulus is 124MPa.

Embodiment 3

[0025] The test conditions and process of the present embodiment are the same as in Example 1, the prepared calcium phosphate bone cement porous support is not added to the chitosan-gelatin solution and poured in, the calcium phosphate bone cement support obtained in the present embodiment The porosity is 77%, the compressive strength is 0.33MPa, and the compressive modulus is 17MPa.

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Abstract

The present invention discloses a preparing method of the calcium phosphate cement / chitosan-gelatin composite scaffold, the process is as follows: mixing the alpha- tricalcium phosphate, monohydrate calcium biphosphate, hydroxyapatite and calcium carbonate according to the mass ration and rubbing, then obtaining the calcium carbonate cement solid powder; mixing the disodium hydrogen phosphate solution and the cement solid powder in the mass ratio and stirring to a mash, then filling into a mould, vacuum solidifying and mold releasing, after that, solidifying again and obtaining the calcium phosphate cement scaffold; subsequently, dissolving the chitosan and the gelatin into the acetic acid water solution, configuring the chitosan-gelatin solution and adding the glutaraldehyde water solution; putting the calcium phosphate cement scaffold into the chitosan-gelatin solution, in vacuum condition, filling chitosan-gelatin solution into the calcium phosphate cement scaffold, after that cooling and drying, obtaining the calcium phosphate cement / chitosan-gelatin composite scaffold. The prepared calcium phosphate cement / chitosan-gelatin composite scaffold has a perfect mechanical property and biological property.

Description

technical field [0001] The invention relates to a preparation method of a calcium phosphate bone cement / chitosan-gelatin composite porous support, which belongs to the biomedical bone tissue material technology. Background technique [0002] In bone tissue repair materials, inorganic calcium phosphates are similar to bone tissue. Calcium phosphate cement (CPC) not only has high biocompatibility as hydroxyapatite (HA) ceramics, but also has self-curing, With the advantages of degradability, convenient operation, and strong plasticity, CPC is a promising new-generation bone repair material. Since the porous scaffold has a microporous structure, it can provide a three-dimensional space for cells to live and make the cells grow according to the prefabricated three-dimensional scaffold. Therefore, the use of calcium phosphate bone cement to prepare porous scaffold materials has become a recent research focus. [0003] With the deepening of bone tissue engineering research, vario...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/20A61L27/24A61L27/12A61F2/28
Inventor 尹玉姬罗春晖李俊杰姚康德
Owner TIANJIN UNIV
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