Surface finishing method of artificial ligament

A technology of artificial ligament and surface modification, applied in the fields of coating, medical science, fiber type, etc., can solve the problem of poor fusion between artificial ligament graft and bone tunnel, increase of operation cost and patient pain, difficulty of graft attachment and fixation and other problems, to achieve the effect of good adhesion, clean surface and high content of peroxy groups

Active Publication Date: 2017-11-24
BEIJING WANJIE MEDICAL DEVICE CO LTD
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the existence of biological and mechanical factors, the fusion of the artificial ligament graft and the bone tunnel is not good, and the expansion of the bone tunnel is more common in clinical practice.
After the bone tunnel is enlarged, it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] Process of the present invention is briefly described as follows with polyethylene terephthalate (PET) fiber fabric as example:

[0040] Immerse the PET artificial ligament fabric in the acidic washing solution composed of hydrochloric acid, tetrahydrofuran, and sodium dodecylbenzenesulfonate, turn on the ultrasonic vibration (frequency 40KHz, power 70W), and wash it with deionized water for 10 minutes until it is washed. The pH of the effluent returned to 7. Then immerse the PET artificial ligament fabric in an alkaline lotion composed of sodium carbonate, tetrahydrofuran, and sodium dodecylbenzenesulfonate, turn on ultrasonic vibration (frequency 40KHz, power 70W), process for 10 minutes, and rinse with deionized water , until the pH of the washed water returned to 7. Use a scanning electron microscope to observe the cleanliness of the fiber surface, and the fiber in the field of view should be smooth without obvious granular residues. The percentage of fiber weight...

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Abstract

The invention relates to a surface finishing method of an artificial ligament. The surface finishing method mainly comprises the following steps: (1) a deep cleaning procedure of an artificial ligament fabric, (2) a peroxidation procedure of a fiber surface, (3) a graft polymerization procedure of the fiber surface, (4) a rewashing procedure and (5) a sectional coating procedure. The surface finishing method is characterized in that by utilizing a multi-step ultrasonic/lotion cooperative treatment manner, a relatively good surface can be obtained; by utilizing an ozone/ultraviolet combined oxidation method, the grafting efficiency is beneficially improved, and the generation of homopolymers is reduced; a grafted hydrophilic polymer layer is of a three-dimensional network-shaped gellike structure, so that a relatively good environment is provided for the development of cells; by carrying out rewashing, the surface of the ligament fabric is relatively clean, and the adhesion, growth and proliferation of the cells are promoted; by sectionally coating a biochemical reagent and a mineralization coating layer, the growth of autologous synovial tissues is easily induced by a ligament joint cavity segment, and the ligament autogeny is beneficially carried out; and the osteogenic property of a bone tunnel segment is enhanced, and the healing of the ligament and bones is relatively good.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a method for surface modification of artificial ligaments. Background technique [0002] Knee cruciate ligament injury is one of the most common knee injuries, usually caused by strenuous knee movement, if not treated in time, it will lead to knee instability and cartilage degeneration, affecting the quality of life of patients. In current cruciate ligament reconstruction treatments, artificial ligaments are increasingly used. [0003] At present, the artificial ligaments widely used in clinic mainly include LARS, Ligastic, Leeds-Keio and Neoligaments, all of which are made of polyethylene terephthalate (PET). Due to the symmetrical molecular structure of PET, high crystallinity, and no strong polar groups in the molecule, its surface affinity is poor, and it is easy to cause postoperative complications such as infection, chronic synovitis, and stiffness after implantation in the hum...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/18D06M11/13D06M11/71D06M11/76D06M13/256D06M14/32D06M15/15D06M101/32
CPCA61L27/18A61L27/34D06M11/13D06M11/71D06M11/76D06M13/256D06M14/32D06M15/15D06M2101/32C08L67/02C08L25/18C08L33/02
Inventor 张梅史丰田
Owner BEIJING WANJIE MEDICAL DEVICE CO LTD
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