Immunity-related biomarker and application of biomarker to prognosis diagnosis of head and neck squamous cell carcinoma

A squamous cell carcinoma and biomarker technology, applied in immune-related biomarkers and its application in the prognostic diagnosis of head and neck squamous cell carcinoma, can solve the problem of immune phenotype prediction. Lack of biomarkers and other problems to achieve the effect of simple and easy detection methods

Active Publication Date: 2020-07-10
JIANGSU CANCER HOSPITAL
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Problems solved by technology

[0005]Despite extensive research on biomarkers in HNSCC, to date there is a lack of reliable prognostic biomarkers in HNSCC other than HPV status , there are few studies focusing on the predictive diagnostic effect of immunophenotype in the disease microenvironment

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  • Immunity-related biomarker and application of biomarker to prognosis diagnosis of head and neck squamous cell carcinoma
  • Immunity-related biomarker and application of biomarker to prognosis diagnosis of head and neck squamous cell carcinoma
  • Immunity-related biomarker and application of biomarker to prognosis diagnosis of head and neck squamous cell carcinoma

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Embodiment 1

[0028] Materials and methods

[0029] 1. Patient samples and public datasets

[0030] From October 2014 to January 2015, we collected fresh tumor tissues and paired adjacent normal tissues from 5 pairs of postoperative HNSCC patients in the Department of Head and Neck Surgery, Cancer Hospital Affiliated to Nanjing Medical University for RNA sequencing analysis to obtain mRNA expression data. For specific clinical and pathological information, see Table 1. The genome-wide mRNA expression (normalized RPKM) RNA-seq data of HNSCC patients were downloaded from The Cancer Genome Atlas (TCGA) database (https: / / tcga-data.nci.nih.gov / tcga / ), and the patients’ gender, Clinicopathological data such as age, histological type, T, N, M stages and follow-up results, among which 416 HNSCC cases with complete gene expression data and TCGA clinical information were further analyzed. From June 2007 to June 2014, 115 patients with HNSCC undergoing head and neck surgery at the Affiliated Cancer ...

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Abstract

The invention discloses an immunity-related biomarker and an application of the biomarker to prognosis diagnosis of head and neck squamous cell carcinoma. The biomarker comprises four immune-related genes PVR, TNFRSF12A, IL-21R and SOCS1, and the biomarker and Path_N jointly form a head and neck squamous cell carcinoma prediction prognosis model. A group of new high-sensitivity and specific immunity-related molecular markers are developed for HNSCC prediction prognosis diagnosis to improve the outcome of a patient, which meets the current urgent demands. A model detection method is simple andeasy to operate, helps to better identify HNSCC patients, and can be used as a guidance basis for HNSCC immunotherapy decisions.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an immune-related biomarker and its application in the prognosis and diagnosis of squamous cell carcinoma of the head and neck. Background technique [0002] Head and neck cancer accounts for more than 630,000 new cases and more than 130,000 deaths each year. Head and neck squamous cell carcinoma (HNSCC) is the most common malignancy of the head and neck, originating from the squamous epithelial cells of the oral cavity, oropharynx, larynx, and hypopharynx. Despite significant progress in multidisciplinary treatment, the 5-year overall survival rate of locally advanced HNSCC has remained at around 50% in recent decades. Given the rising incidence and poor survival outcomes, there is an urgent need for targeted prevention, screening, and treatment approaches for HNSCC. [0003] In the face of the poor efficacy of conventional HNSCC treatment and few options for t...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 陈云张园姚瑶闫忠义杨建荣练森林魏良念周超冯东举
Owner JIANGSU CANCER HOSPITAL
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