Kidney-tonifying and liver-nourishing compound preparation and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a kidney-tonifying and liver-nourishing compound preparation and a preparation method thereof. The compound preparation comprises 5-15 parts of roasted herba epimedii, 5-15 parts of fructus cnidii, 50-70 parts of roasted radix astragali and 10-30 parts of pulp of dogwood fruit. The traditional Chinese medicine composition has remarkable curative effects on various diseases and chronic strain caused by deficiency of liver and kidney and deficiency of blood and essence, such as dizziness, blurred vision, fatigue, swelling and pain of waist, back and limbs, dry mouth and eyes, limb ache and weakness, irregular menstruation, incapability of holding weight or hemiplegia and the like, and has a very good application prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a compound preparation for tonifying the kidney and nourishing the liver and a preparation method thereof. Background Art

[0002] The liver, an organ in the human body and one of the five internal organs, is an organ mainly responsible for metabolic functions in vertebrates. It fully plays roles such as deoxidation, storing glycogen, synthesizing secretory proteins, etc. The liver also produces bile in the digestive system. In medical terms, the Latin prefix hepato- or hepatic is often used to describe the liver. Most liver diseases will have symptoms of jaundice, which is due to the liver's inability to continue excreting bilirubin, so it accumulates in the body. Traditional Chinese medicine believes that: the liver and the gallbladder are exterior-interiorly related, open into the eyes, the liver is mainly responsible for storing blood and regulating qi flow, and has the function of storing and regulating blood. In "Plain Questions - Generation of the Five Viscera", it is stated that: "The liver is related to the tendons, and its brilliance is manifested in the nails." The liver is also called the "general" organ, mainly responsible for planning. In "Medical Records of Clinical Practice Guidelines - Liver Wind", there is a saying that the liver is "yin in substance and yang in function". The physiological characteristics of the liver are to mainly ascend and be active, like to be smooth and dislike depression, so it is called the "hard organ". In "Plain Questions - Secret Canon of the Spiritual Orchid", it is said that: "The liver is the general organ, and strategies are generated from it." The kidney, pronounced shèn, is composed of the character "肉" (meat) and "臤" (qiān), and "臤" also serves as a phonetic component. The original meaning of "臤" is "firmly controlling subordinates". "肉" refers to the "human body". The combination of "臤" and "肉" represents the "controlling part of the human body". The kidneys are located on both sides of the spinal column in the waist, one on each side. In "Plain Questions - Pulse Manifestation and Subtlety Theory", it is said that: "The waist is the residence of the kidneys." The main physiological functions of the kidneys are: mainly storing essence, regulating water metabolism, and receiving qi. Since the kidneys store congenital essence, are responsible for reproduction, and are the origin of human life, the kidneys are called the "foundation of congenital nature". The essence of the kidneys is transformed into kidney qi, and kidney qi is divided into yin and yang. Kidney yin and kidney yang can assist, promote, and coordinate the yin and yang of all internal organs in the body, so the kidneys are also called the "foundation of the yin and yang of the five internal organs". The kidneys store essence, are mainly in a state of closure, and are also called the "foundation of storage". The kidneys are related to the bones in the body, produce marrow, communicate with the brain, their brilliance is manifested in the hair, open into the ears and the two lower yin, are related to fear in the mind, and secrete saliva. The Kidney Meridian of Foot-Shaoyin and the Bladder Meridian of Foot-Taiyang are mutually interior-exteriorly related to the kidneys and the bladder. The kidneys belong to water in the five elements, are yin within yin, and correspond to the winter qi in nature.

[0003] Traditional Chinese medicine considers the kidneys to be the "foundation of innate essence" and the "root of life." Human growth, development, and aging are determined by the strength of the kidney's essence and qi. The maturation and decline of male and female reproductive functions are also based on the kidney's essence and qi. Kidney essence belongs to yin, and kidney qi belongs to yang; therefore, kidney essence is called kidney yin, and kidney qi is called kidney yang. Kidney yin plays a nourishing and moisturizing role for all organs and is the root of the body's yin fluids. Kidney yang plays a warming and biochemical role for all organs and is the root of the body's yang qi. Kidney yin and kidney yang are both relative and interactive. Human aging generally begins with the kidneys, leading to the decline of other organs. Simultaneously, related tissues and organs will inevitably undergo certain changes. For example, the kidneys govern bones, produce marrow, nourish the brain, and are responsible for skills and agility. The waist is the residence of the kidneys, teeth are an extension of bones, the ears are the orifice, the pupils belong to the kidneys, and the health of the hair is reflected in the skin. Therefore, kidney deficiency leads to corresponding aging phenomena such as lower back pain, weak legs, dizziness, and forgetfulness.

[0004] Liver and kidney deficiency, or inadequate liver and kidney function, primarily refers to liver and kidney yin deficiency, meaning insufficient essence and blood. Symptoms include dizziness, as the brain stores marrow, which is transformed from kidney essence, and blood is the material basis for mental activity; therefore, liver and kidney deficiency leads to malnourishment of the brain, causing dizziness. Dry eyes are also common, as liver blood and kidney essence nourish the eyes; the saying "the eyes can see only with blood" refers to the nourishment from liver blood and kidney essence. Bilateral posterior tremor may also occur, as liver blood and kidney essence nourish and moisturize the joints. Stroke is also possible, as liver and kidney yin deficiency weakens the body's ability to control yang, leading to an excess of yang and a higher risk of cerebrovascular accidents. Furthermore, in traditional Chinese medicine, "eye fatigue" is most commonly attributed to liver and kidney deficiency, its pathogenesis being insufficient liver and kidney essence and blood, resulting in malnourishment of the eyes and tendons. Based on the theory of "seeking yin within yang," it is believed that it is necessary to warm and tonify kidney yang to generate kidney essence, as the liver and kidneys share a common origin, and essence and blood share a common origin; therefore, tonifying kidney essence nourishes liver blood. Traditional Chinese medicine is profound and extensive, and the study of liver and kidney deficiency is endless. Summary of the Invention

[0005] The purpose of this invention is to provide a compound preparation for nourishing the kidneys and liver, which is used for various diseases and chronic strain caused by liver and kidney deficiency, blood deficiency and sperm depletion, and has the effects of tonifying qi and strengthening the spleen, nourishing the kidneys and liver, and strengthening muscles and bones.

[0006] Specifically, the present invention is achieved through the following techniques: A compound preparation for tonifying the kidney and nourishing the liver, the compound preparation being composed of the following raw materials in parts by weight: 5-15 parts of processed Epimedium, 5-15 parts of Cnidium monnieri, 50-70 parts of processed Astragalus membranaceus, and 10-30 parts of Cornus officinalis.

[0007] Preferably, the compound preparation is composed of the following raw materials in parts by weight: 7-12 parts of processed Epimedium, 7-12 parts of Cnidium monnieri, 55-65 parts of processed Astragalus membranaceus, and 15-25 parts of Cornus officinalis.

[0008] More preferably, the compound preparation is composed of the following raw materials in parts by weight: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0009] Preferably, the compound preparation is prepared by mixing the extract powders obtained from each raw material drug through a specific extraction method according to the weight component ratio.

[0010] The dosage form of the lipid-lowering and turbidity-reducing composition of the present invention can be a medically acceptable dosage form such as oral liquid, capsule, granules, tablet, decoction, pill, tea bag, or instant tea.

[0011] In a second aspect, this invention provides a method for preparing a kidney-tonifying and liver-nourishing compound preparation. Based on the function and characteristics of each component, different pre-treatment methods and extraction methods for the target components are employed. This preparation method can improve the extraction rate of the active ingredients, destroy interfering components, and reduce the content of interfering components, thereby enhancing the effects of clearing turbidity and lowering lipids.

[0012] Each raw material is pretreated to obtain an extract, which is then concentrated into a thick paste and vacuum dried. The resulting dried thick paste is mixed, pulverized, and sieved. The conventional amounts of soluble starch and maltodextrin are added, and the mixture is then processed into granules, capsules, and tablets using conventional processes.

[0013] The specific steps are as follows: 1) Raw material pre-processing: a. Processed Epimedium: Weigh fresh Epimedium, wash it, pick the leaves, spray with water to moisten slightly, shred and dry; wash and rinse fresh male goat fat, cut into small pieces, place in a pot with water and pressurize, the pressing temperature is 120-150℃, when the oil is extracted and the residue turns old yellow, remove the residue and cool to obtain mutton fat; put the mutton fat into a stir-frying machine and heat to melt, take 30kg of mutton fat for every 100kg of Epimedium, then add the Epimedium shreds, set the temperature of the stir-frying machine to 120-170℃, the stir-frying time is controlled at 5-10 minutes, stir-fry over low heat until even and shiny, remove and let cool.

[0014] Weigh out the prescribed amount of processed Epimedium, and extract it twice by heating and refluxing with 50%-60% ethanol for 2 hours each time. Combine the extracts, filter them, recover the ethanol from the filtrate and concentrate it into a thick paste, then dry it for later use. b. Cnidium monnieri: Weigh the prescribed amount of dried Cnidium monnieri, crush it, pass it through an 80-mesh sieve, add 80%-90% ethanol solution, heat and reflux to extract twice, filter, combine the filtrates, concentrate into a thick paste, and dry for later use; c. Prepared Astragalus: Add 0.5-1 times (w / w) of water to 25% of the weight of refined honey, mix well, place the raw Astragalus slices in the above-mentioned refined honey with added water, mix well, and let it soak for 1 hour until the refined honey is fully absorbed by the Astragalus slices; then heat, turning it once every 2 minutes during the process, heat for 4 minutes, and then place it in an oven at 100 ℃ for 30 minutes, until the surface of the slices is dark yellow to light brownish-yellow, remove it and let it cool.

[0015] Weigh the prescribed amount of roasted Astragalus membranaceus, crush it into granules, add 6-10 times (w / w) of water, heat to 75-80℃ and extract for 2 hours, filter out the filtrate; then place the residue in 6-8 times the volume of water and extract by ultrasonication for 1 hour, filter, combine the filtrates to obtain the extract, concentrate the extract under reduced pressure to obtain the extract, and dry it for later use. d. Cornus officinalis: Weigh the prescribed amount of Cornus officinalis, add 6-10 times (w / w) of water, heat and reflux to extract twice, 2 hours each time, combine the extracts, filter, concentrate into a thick paste, and dry for later use; 2) Preparation of compound formulations: The obtained dried extract is mixed, pulverized and sieved. The mixture of excipients soluble starch and maltodextrin is pulverized and sieved. The pulverized extract is mixed evenly with maltodextrin and soluble starch, granulated and packaged to obtain the turbidity-reducing and lipid-lowering composition of the present invention.

[0016] Preferably, the dried extract is pulverized to a particle size of 80-120 mesh, more preferably 100 mesh.

[0017] Preferably, the amount of the mixed excipients added is 5-10% of the weight of the extract mixture.

[0018] Preferably, the weight ratio of maltodextrin to soluble starch in the mixed excipients is 1:1 to 5; more preferably, it is 1:3.

[0019] In one embodiment, the specific steps of wet granulation are as follows: take the pulverized extract and mixed excipients in proportion, mix them evenly, moisten the soft material with an appropriate amount of 95% ethanol, knead and mix evenly, granulate, sizing, drying, and packaging.

[0020] The beneficial effects of this invention are: This invention has significant therapeutic effects on various diseases and chronic strains caused by liver and kidney deficiency, blood deficiency and sperm depletion, with symptoms such as dizziness, blurred vision, fatigue, swelling and pain in the lower back and limbs, dry mouth and eyes, soreness and weakness in the limbs, irregular menstruation, inability to lift heavy objects or hemiplegia. Detailed Implementation

[0021] The present invention will be further illustrated by the following examples. Unless otherwise specified, the experimental methods used in the following examples are conventional methods; the materials and reagents used are commercially available unless otherwise specified.

[0022] Example 1: Preparation of 1000ml decoction A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0023] Its preparation method includes the following steps: 1) Raw material pre-processing: a. Processed Epimedium: Weigh fresh Epimedium, wash it, pick the leaves, spray with water to moisten slightly, shred and dry; wash and rinse fresh male goat fat, cut into small pieces, place in a pot with water and pressurize, the pressing temperature is 120-150℃, when the oil is extracted and the residue turns old yellow, remove the residue and cool to obtain mutton fat; put the mutton fat into a stir-frying machine and heat to melt, take 30kg of mutton fat for every 100kg of Epimedium, then add the Epimedium shreds, set the temperature of the stir-frying machine to 120-170℃, the stir-frying time is controlled at 5-10 minutes, stir-fry over low heat until even and shiny, remove and let cool.

[0024] Weigh out the prescribed amount of processed Epimedium, extract it twice by heating and refluxing with 60% ethanol for 2 hours each time, combine the extracts and filter, recover the ethanol from the filtrate and concentrate it to obtain the extract, which is then vacuum dried for later use. b. Cnidium monnieri: Weigh the prescribed amount of dried Cnidium monnieri, crush it, pass it through an 80-mesh sieve, add 90% ethanol solution, heat and reflux to extract twice, filter, combine the filtrates and concentrate to obtain an extract, vacuum dry it, and set it aside for later use; c. Prepared Astragalus: Add 0.5 times (w / w) of water to 25% of the weight of refined honey, mix well, place the raw Astragalus slices in the above-mentioned refined honey with added water, mix well, and let it soak for 1 hour until the refined honey is fully absorbed by the Astragalus slices; then heat, turning it once every 2 minutes during the process, heat for 4 minutes, and then place it in an oven at 100 ℃ for 30 minutes, until the surface of the slices is dark yellow to light brownish-yellow, remove it, and let it cool; Weigh out the prescribed amount of roasted Astragalus membranaceus, crush it into granules, add 10 times (w / w) of water, heat to 80℃ and extract for 2 hours, filter out the filtrate; then place the residue in 8 times the volume of water and extract by ultrasonication for 1 hour, filter, combine the filtrates to obtain the extract, concentrate the extract under reduced pressure to obtain the extract, and dry it for later use. d. Cornus officinalis: Weigh the prescribed amount of Cornus officinalis, add 6 times (w / w) of water, heat and reflux to extract twice, 2 hours each time, combine the extracts, filter and concentrate to obtain the extract, vacuum dry and set aside. 2) Preparation of compound formulations: The obtained dried extract was mixed and pulverized through a 100-mesh sieve for later use. A mixture of maltodextrin and soluble starch in a weight ratio of 1:3 was pulverized through a 100-mesh sieve for later use. The pulverized extract was mixed evenly with 8% by weight of maltodextrin and soluble starch in the mixture, granulated, and packaged to obtain a kidney-tonifying and liver-nourishing compound preparation.

[0025] Example 2 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 5 parts of processed Epimedium, 15 parts of Cnidium monnieri, 50 parts of processed Astragalus membranaceus, and 10 parts of Cornus officinalis.

[0026] Preparation method: The extracts of each component were prepared according to the method in step 1 of Example 1. The dried extracts were weighed according to the proportion, mixed, and pulverized to a particle size of 80 mesh using ultrafine powder. A mixture of maltodextrin and soluble starch in a weight ratio of 1:5 was ground into fine powder and passed through a 50-mesh sieve. The pulverized extracts were mixed evenly with 10% by weight of maltodextrin and soluble starch, granulated, and packaged to obtain a kidney-tonifying and liver-nourishing compound preparation.

[0027] Example 3 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 15 parts of processed Epimedium, 5 parts of Cnidium monnieri, 70 parts of processed Astragalus membranaceus, and 30 parts of Cornus officinalis.

[0028] Preparation method: The extracts of each component were prepared according to the method in step 1 of Example 1. The dried extracts were weighed in proportion, mixed, and pulverized to a particle size of 120 mesh using ultrafine powder. A mixture of maltodextrin and soluble starch in a weight ratio of 1:1 was ground into fine powder and passed through a 50-mesh sieve. The pulverized extracts were mixed evenly with 5% by weight of maltodextrin and soluble starch, granulated, and packaged to obtain the turbidity-reducing and lipid-lowering composition.

[0029] Comparative Example 1 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 30 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0030] Preparation method: The preparation method of the above compound preparation is the same as that in Example 1.

[0031] Comparative Example 2 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 30 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0032] Preparation method: The preparation method of the above compound preparation is the same as that in Example 1.

[0033] Comparative Example 3 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 130 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0034] Preparation method: The preparation method of the above compound preparation is the same as that in Example 1.

[0035] Comparative Example 4 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 50 parts of Cornus officinalis.

[0036] Preparation method: The preparation method of the above compound preparation is the same as that in Example 1.

[0037] Comparative Example 5 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0038] Preparation method: Following the method in Example 1, Epimedium and Astragalus were processed separately to obtain processed Epimedium and processed Astragalus. The prescribed amounts of processed Epimedium, Cnidium monnieri, processed Astragalus and Cornus officinalis were added to 8 times (w / w) of water and decocted twice, 2 hours each time. The decoctions were combined, filtered and concentrated to obtain an extract, which was vacuum dried and pulverized through a 100-mesh sieve for later use. A mixture of maltodextrin and soluble starch in a weight ratio of 1:3 was pulverized through a 100-mesh sieve for later use. The pulverized extract was mixed evenly with 8% by weight of maltodextrin and soluble starch in the mixture, granulated, and packaged to obtain a kidney-tonifying and liver-nourishing compound preparation.

[0039] Comparative Example 6 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0040] Preparation method: Following the method in Example 1, Epimedium and Astragalus were processed separately to obtain processed Epimedium and processed Astragalus. The prescribed amounts of processed Epimedium, Cnidium monnieri, processed Astragalus, and Cornus officinalis were placed in 8 times their volume of 65% ethanol solution and heated to 50-55℃ for 2 hours. The filtrate was then filtered. The residue was then placed in 6 times their volume of 65% ethanol solution for ultrasonic extraction for 1.5 hours, filtered, and the filtrates were combined to obtain the extract. Ethanol was recovered until the filtrate had no alcohol odor. The extract was concentrated under reduced pressure to obtain an extract, which was then dried for later use. The obtained dried extract was pulverized to a particle size of 100 mesh and then ground into a fine powder. A mixture of maltodextrin and soluble starch in a weight ratio of 1:3 was passed through a 50-mesh sieve. The pulverized extract was mixed evenly with 8% by weight of the mixture of maltodextrin and soluble starch, granulated, and packaged to obtain a kidney-tonifying and liver-nourishing compound preparation.

[0041] Comparative Example 7 A compound preparation for tonifying the kidney and nourishing the liver, the components of each raw material are: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

[0042] Preparation method: The extracts of each component were prepared according to the method in Example 1. The dried extracts were mixed and pulverized to a particle size of 50 mesh using ultrafine powder. A mixture of maltodextrin and soluble starch in a weight ratio of 2:1 was ground into fine powder and passed through a 50-mesh sieve. The pulverized extracts were mixed evenly with 5% by weight of maltodextrin and soluble starch, granulated, and packaged to obtain a kidney-tonifying and liver-nourishing compound preparation.

[0043] Verification Example: animal testing (1) Effects of the composition of the present invention on mice with "liver and kidney deficiency" and exercise fatigue Seventy-two male SPF-grade Kunming mice, 4 weeks old, weighing (20±2)g, were used. The mice were fed regular feed and had free access to water. The room temperature was 22~26 ℃, the relative humidity was 60%~70%, and the lamp illumination cycle was 12 h.

[0044] After one week of acclimatization, six mice were placed in a control group and fed a normal diet with free access to water. The remaining 66 mice were placed in an electric stimulation cage, where stimulation was administered every 15 seconds for 0.2-0.5 seconds. Upon stimulation, the animals ran, jumped, and turned along the stimulation cage. Training lasted 120 minutes daily for three weeks. During the training period, the mice were fed a normal diet with free access to water. After one week of training, the mice began to show significant weight loss. After three weeks of training, the mice exhibited weight loss, decreased serum testosterone levels, lethargy, and dull fur.

[0045] After 3 weeks of training, 66 trained mice were randomly divided into 11 groups of 6 mice each: a model group, drug treatment groups 1-10 (Examples 1-3, Comparative Examples 1-7), and 6 untrained mice as a normal control group. Each group was administered the corresponding drug by gavage every morning. Drug treatment groups 1-10 were given the compositions obtained in Examples 1-3 and Comparative Examples 1-7, respectively, at a dosage of 1 g / kg (based on the total weight of the prescribed raw materials). The control group and model group were given the same amount of distilled water. The administration was continued for 14 days, and various indicators were measured.

[0046] Table 3. Detection indicators of exercise-fatigued mice Compared with the normal control group, the model group mice showed a significant decrease in body weight, a decrease in serum testosterone levels, a significant increase in fibrinogen, and dull, lackluster fur. After drug administration, all indicators in the mice of Examples 1-3 improved, approaching the levels of the normal group.

[0047] (2) Effects of the composition of the present invention on mice with visual fatigue due to "liver and kidney yin deficiency" Seventy-two male SPF-grade Kunming mice, 4 weeks old, weighing (20±2)g, were used. The mice were fed regular feed and had free access to water. The room temperature was 22~26 ℃, the relative humidity was 60%~70%, and the lamp illumination cycle was 12 h.

[0048] After one week of acclimatization, the animals were randomly divided into 12 groups of 6 animals each, based on their body weight: a normal control group, a model group, and treatment groups 1-10 (Examples 1-3 and Comparative Examples 1-7). Every morning, the treatment groups were administered the corresponding medication by gavage at a dose of 1 g / kg (based on the total weight of the prescribed raw materials). The normal control group and the model group were administered an equal volume of distilled water by gavage. Treatment groups 1-10 were given the compositions obtained in Examples 1-3 and Comparative Examples 1-7, respectively, once daily for 14 consecutive days. Every afternoon, the model group and the treatment groups were administered levothyroxine sodium (150 μg / kg) by gavage at a volume of 0.02 mL / g, with the gavage volume adjusted according to changes in body weight. Then, emotional stimulation was provided by clamping the tail (approximately 3 cm from the tail tip) for 5 minutes. Both gavage and tail clamping were performed once daily for 14 days. On day 15, samples were collected. Blood was collected from the eyeballs, and the animals were quickly dissected.

[0049] Table 4 Serum cyclic nucleotide levels in mice with visual fatigue Compared with the normal group of mice, the model group of mice had increased serum cAMP / cGMP levels, decreased liver SOD activity, and increased MDA content. After administration, the indicators in Examples 1-3 were closer to those in the normal group, showing significant effects.

[0050] Clinical application From January 2020 to January 2022, 98 patients with various diseases and chronic strain caused by liver and kidney deficiency, blood deficiency and sperm depletion visited the outpatient clinic. Among them, 36 patients presented with the following clinical symptoms: 1) dizziness, blurred vision, fatigue, and swelling and pain in the lower back and limbs; 33 patients presented with the following clinical symptoms: 2) fatigue, dry mouth and tongue, limb soreness and weakness, and inability to bear weight; 23 female patients presented with the following clinical symptoms: 3) menstrual irregularities; and 6 patients presented with the following clinical symptoms: 4) hemiplegia. The preparation prepared in Example 1 of this invention was administered twice daily, 50g each time (based on the total weight of the prescription raw materials), for 4 weeks. Efficacy criteria: Cured: complete disappearance of symptoms and signs. Significant effect: The condition has improved significantly, and the symptoms have been significantly reduced; Improvement: The condition has improved and symptoms have lessened; Ineffective: The condition does not change or worsens, and the symptoms and signs do not improve.

[0051] Overall effectiveness rate = (Number of cured patients + Number of patients showing significant improvement + Number of patients showing improvement) / Total number of patients × 100% Results: Table 5 Treatment efficacy This invention is remarkably effective for various diseases and chronic strains caused by liver and kidney deficiency, blood deficiency and sperm depletion, with symptoms such as dizziness, blurred vision, fatigue, swelling and pain in the lower back and limbs, dry mouth and eyes, soreness and weakness in the limbs, irregular menstruation, inability to lift heavy objects or hemiplegia. The total effective rate for symptoms one, two and three is over 93.94%.

[0052] It should be noted that the embodiments of the present invention are merely for illustrating the present invention and are not intended to limit the present invention. Therefore, any simple improvements to the present invention under the premise of the method of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A compound preparation for tonifying the kidney and nourishing the liver, characterized in that, The compound preparation contains the following components: 5-15 parts of processed Epimedium, 5-15 parts of Cnidium monnieri, 50-70 parts of processed Astragalus membranaceus, and 10-30 parts of Cornus officinalis.

2. The compound formulation according to claim 1, characterized in that, The compound preparation consists of the following components in parts by weight: 7-12 parts of processed Epimedium, 7-12 parts of Cnidium monnieri, 55-65 parts of processed Astragalus membranaceus, and 15-25 parts of Cornus officinalis.

3. The compound formulation according to claim 1, characterized in that, The compound preparation consists of the following components in parts by weight: 10 parts of processed Epimedium, 10 parts of Cnidium monnieri, 60 parts of processed Astragalus membranaceus, and 20 parts of Cornus officinalis.

4. A kidney-tonifying and liver-nourishing compound preparation according to any one of claims 1-3, characterized in that... The compound preparation is formulated with medically acceptable excipients and prepared into any one of the following: decoction, granules, pills, tablets, capsules, ointments, syrups, and powders.

5. A method for preparing the compound formulation according to claim 1, characterized in that, The specific steps are as follows: 1) Raw material pre-processing: a. Processed Epimedium: Weigh fresh Epimedium, wash it, pick the leaves, spray with water to moisten slightly, shred and dry; wash and rinse fresh male goat fat, cut into small pieces, place in a pot with water and pressurize at 120-150℃, when the oil is extracted and the residue turns dark yellow, remove the residue and cool to obtain mutton fat; heat and melt the mutton fat in a stir-frying machine, take 30kg of mutton fat for every 100kg of Epimedium, then add the Epimedium shreds, set the temperature of the stir-frying machine to 120-170℃, control the stir-frying time to 5-10 minutes, stir-fry over low heat until even and shiny, remove and let cool for later use; Weigh out the prescribed amount of processed Epimedium, and extract it twice by heating and refluxing with 50%-60% ethanol for 2 hours each time. Combine the extracts, filter them, recover the ethanol from the filtrate and concentrate it into a thick paste, then dry it for later use. b. Cnidium monnieri: Weigh the prescribed amount of dried Cnidium monnieri, crush it, pass it through an 80-mesh sieve, add 80%-90% ethanol solution, heat and reflux to extract twice, filter, combine the filtrates, concentrate into a thick paste, and dry for later use; c. Prepared Astragalus: Add 0.5-1 times the amount of water to 25% of the weight of refined honey, mix well, place the raw Astragalus slices in the above-mentioned refined honey with added water, mix well, and let it soak for 1 hour until the refined honey is fully absorbed by the Astragalus slices; then heat, turning it once every 2 minutes during the process, heat for 4 minutes, and then place it in an oven at 100 ℃ for 30 minutes, until the surface of the slices is dark yellow to light brownish-yellow, remove it, and let it cool for later use; Weigh out the prescribed amount of roasted Astragalus membranaceus, crush it into granules, add 6-10 times the amount of water, heat to 75-80℃ and extract for 2 hours, filter out the filtrate; then place the residue in 6-8 times the volume of water and extract by ultrasonication for 1 hour, filter, combine the filtrates to obtain the extract, concentrate the extract under reduced pressure to obtain the extract, and dry it for later use. d. Cornus officinalis: Weigh the prescribed amount of Cornus officinalis, add 6-10 times the amount of water, heat and reflux to extract twice, 2 hours each time, combine the extracts, filter, concentrate into a thick paste, and dry for later use; 2) Preparation of compound formulations: The obtained dried extract is mixed and then pulverized using ultrafine powder for later use. The mixture of excipients soluble starch and maltodextrin is ground into fine powder and passed through a 50-mesh sieve for later use. The pulverized extract is mixed evenly with maltodextrin and soluble starch, granulated, and packaged to obtain the turbidity-reducing and lipid-lowering composition of the present invention.

6. The preparation method according to claim 5, characterized in that, The dried extract is pulverized to a particle size of 80-120 mesh, preferably 100 mesh.

7. The preparation method according to claim 5, characterized in that, The amount of excipients added is 5-10% of the weight of the extract mixture.

8. The preparation method according to claim 5, characterized in that, The weight ratio of maltodextrin to soluble starch is 1:1 to 5, preferably 1:

3.

9. The use of the kidney-tonifying and liver-nourishing compound preparation according to any one of claims 1-3 in the preparation of a drug for treating liver and kidney deficiency.

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