Application of beta 3-adrenergic receptor agonist in preparation of medicine for treating brain injury

A technology of epinephrine and therapeutic drugs, applied in the field of medicine, can solve the problem of lack of effective surgical or recognized drug treatment methods for cerebral hemorrhage, and achieve the effect of inhibiting focal brain inflammation and edema
CN112451522AInactive Publication Date: 2021-03-09BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Publication Date
2021-03-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicines, and relates to application of a beta 3-adrenergic receptor agonist in preparation of a medicine for treating or preventing brain injury. Theresearch finds that the beta 3-adrenergic receptor agonist can increase Ly6Clow mononuclear cells and macrophages expressing alternative activation markers (CD206 and PD-L2) in the brain of a cerebralhemorrhage model mouse, and reduce neutrophil and lymphocyte which are infiltrated by brain tissues; and the beta 3-adrenergic receptor agonist promotes intramedullary hematopoiesis of the Ly6Clow mononuclear cells, promotes the Ly6Clow mononuclear cells and the macrophages to express IL-10, can effectively inhibit focal brain inflammation and edema after cerebral hemorrhage, and has important clinical application value for treating the brain injury after the cerebral hemorrhage. The invention further discloses a pharmaceutical composition. The pharmaceutical composition comprises the beta 3-adrenergic receptor agonist, and can be used as a medicine for treating the brain injury caused by the cerebral hemorrhage.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to the application of β3-adrenergic receptor agonists in the preparation of medicines for the treatment or prevention of brain damage, in particular to the application of Mirabegron in the preparation of medicines for the treatment or prevention of brain damage. Background technique

[0002] Intracranial hemorrhage (ICH) refers to hemorrhage caused by rupture of blood vessels in the non-traumatic brain parenchyma, accounting for 20% to 30% of all strokes, and the fatality rate in the acute phase is 30% to 40%. In my country, the incidence rate of cerebral hemorrhage is 60-80 / (100,000 people per year), and the prevalence rate is 112 / 100,000 people, which is much higher than that in Western countries and other Asian countries. It has been reported that the mortality rate 1 month after cerebral hemorrhage is 40%, and most of the survivors have sequelae such as movement disorders, cognit...

Claims

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