Application of polysaccharide in medicament for treating or preventing primary cerebral hemorrhage

Abstract

The invention relates to novel application of the medical effect of polysaccharide, in particular to application of polysaccharide in a medicament for treating or preventing primary cerebral hemorrhage. An SD (Sprague Dawley) rat cerebral hemorrhage model is used as an experimental material, and the polysaccharide is used for treating an SD rat with primary cerebral hemorrhage neuronal damage, no matter the drug administration is carried out before or after the model, the polysaccharide has the effect of reducing encephaledema (BBB, brain blood barrier) in the cerebral hemorrhage model; drug administration before hemorrhage indicates that the inhibition ratios to brain water content (BBB) are respectively 10.4 percent and 13.3 percent if dosages are 60 and 100mg / kg, and the prevention effect is good; and drug administration before hemorrhage indicates that the inhibition ratios to the brain water content (BBB) are respectively 9.5 percent and 12 percent if dosages are 60 and 100mg / kg. The remarkable medical effect of the polysaccharide in cerebral hemorrhage treatment before clinical application indicates the clinical treatment practicability of polysaccharide in cerebral hemorrhage treatment. The polysaccharide can be used as a prevention medicament and a treatment medicament to improve the cure rate and survival rate of cerebral hemorrhage and has good treatment effect.

Description

technical field [0001] The invention relates to a new medicinal application of bitter gourd polysaccharide, in particular to the application of bitter gourd polysaccharide in medicine for treating or preventing primary cerebral hemorrhage. Background technique [0002] Bitter melon (Momordica charantia, MC), also known as bitter gourd, brocade litchi, epilepsy melon, is a plant of the genus Momordica cucurbitaceae. Bitter gourd is a famous folk Chinese herbal medicine. The medicinal record of bitter gourd was first recorded in "Southern Yunnan Materia Medica" in the Ming Dynasty, and there were many records thereafter. "Compendium of Materia Medica" says: "Remove evil heat, relieve fatigue, clear heart and eyesight, replenish qi and strengthen yang". The research on the medicinal value of bitter melon has made important progress at home and abroad, and the research on the active ingredients of bitter melon is still in progress. [0003] Document 1: H Okabe, Y Miyahara, T ...

AI Technical Summary

Problems solved by technology

[0006] However, there is still no data to support the effective use of bitter melon polysaccharides in the treatment of cerebral hemorrhage, an acute and spontaneous blood spillage into the brain parenchyma, which is the cause of disability and death worldwide. Restoring cerebral blood flow supply and enhancing neuron protection are two strategies for the treatment of ischemic cerebral hemorrhage, but the clinical effect of these two strategies is not satisfactory so far.

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