Method for constructing canine cerebral hemorrhage model

A construction method and model technology, applied in medical science, veterinary instruments, veterinary surgery, etc., can solve problems such as high success rate and lack of fine bleeding models in large animals, and achieve high success rate and simple operation
CN113274161APending Publication Date: 2021-08-20SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
Publication Date
2021-08-20

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Abstract

The invention relates to the technical field of animal model construction, in particular to a method for constructing a canine cerebral hemorrhage model. The method comprises the following steps of sequentially cutting skin and subcutaneous tissues, separating cranial top muscles and exposing skull by taking a sagittal seam at the rear top of the head of a model dog after prone position fixation and anesthesia as an incision, moving 1.5-2.5 cm from the joint of the crest and the sagittal crest to the face direction, and then moving 0.5-1.5 cm to the right outer side to open a bone window, opening the dura mater, exposing the top lobe of the brain tissue, and clamping the cerebral cortex tissue after hemostasis, wherein the clamping range is not more than 3mm *3mm, and the clamping depth is not more than 2mm. The hemorrhage model can reflect the tiny errhysis condition in the neurosurgery operation process, the construction method is easy to operate, no adverse reaction exists, and the success rate is high.
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Description

technical field

[0001] The invention relates to the technical field of animal model construction, in particular to a method for constructing a canine cerebral hemorrhage model. Background technique

[0002] Animal models of human diseases are mainly used in experimental physiology, experimental pathology, experimental pharmacology, new drug safety evaluation and medical device biological evaluation and efficacy degradation research. With the help of indirect research on animal models, it is possible to consciously change the Factors that may or are not easy to exclude, more accurate observation of model experiment results, and comparative studies with human diseases will help to understand the occurrence and development of human diseases more conveniently and effectively, and have an irreplaceable role in the study of disease prevention and control measures. Significance.

[0003] Currently commonly used cerebral hemorrhage models include collagenase injection cerebral hemo...

Claims

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