Method for constructing canine cerebral hemorrhage model

A construction method and model technology, applied in medical science, veterinary instruments, veterinary surgery, etc., can solve problems such as high success rate and lack of fine bleeding models in large animals, and achieve high success rate and simple operation

Pending Publication Date: 2021-08-20
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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Problems solved by technology

[0005] Aiming at the technical problem that the existing neurosurgical cerebral hemorrhage models are generally small animal hemorrhage models, which lack the fine hemorrhage models of large animals, the present invention utilizes that the canine hemodynamics and brain function anatomical structure are similar to those of humans, and the proportion of blood volume is 7% of the body weight. % to 8%, providing a method for constructing a canine cerebral hemorrhage model. The hemorrhage model can reflect the subtle bleeding in the brain during the surgical operation of the human body. The construction method is simple to operate. The model dog has no adverse reactions and has a high success rate

Method used

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  • Method for constructing canine cerebral hemorrhage model
  • Method for constructing canine cerebral hemorrhage model
  • Method for constructing canine cerebral hemorrhage model

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Embodiment 1

[0023] A total of 6 Beagle dogs, 1-1.5 years old and 10±2kg in weight, qualified for quarantine inspection, including 3 male dogs and 3 female dogs, were selected to construct a canine cerebral hemorrhage model. The construction process is as follows: figure 1 As shown, use the mixture of Sumianxin and Shutai to anesthetize and fix in prone position, remove about 5cm of dog hair around the area to be operated, disinfect with 75% alcohol under aseptic conditions, and spread sterile surgical drapes ;

[0024] Make an incision about 5 cm long at the sagittal suture position on the back top of the head, cut the skin and subcutaneous tissue in sequence, fully stop the bleeding, separate the cranial muscles with an electric knife, expose the skull, and move toward the face at the junction of the parietal crest and the sagittal crest Move about 2cm, and then move about 1cm to the right lateral side, open an oval bone window with a long axis of about 4cm and a short axis of about 2cm ...

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Abstract

The invention relates to the technical field of animal model construction, in particular to a method for constructing a canine cerebral hemorrhage model. The method comprises the following steps of sequentially cutting skin and subcutaneous tissues, separating cranial top muscles and exposing skull by taking a sagittal seam at the rear top of the head of a model dog after prone position fixation and anesthesia as an incision, moving 1.5-2.5 cm from the joint of the crest and the sagittal crest to the face direction, and then moving 0.5-1.5 cm to the right outer side to open a bone window, opening the dura mater, exposing the top lobe of the brain tissue, and clamping the cerebral cortex tissue after hemostasis, wherein the clamping range is not more than 3mm *3mm, and the clamping depth is not more than 2mm. The hemorrhage model can reflect the tiny errhysis condition in the neurosurgery operation process, the construction method is easy to operate, no adverse reaction exists, and the success rate is high.

Description

technical field [0001] The invention relates to the technical field of animal model construction, in particular to a method for constructing a canine cerebral hemorrhage model. Background technique [0002] Animal models of human diseases are mainly used in experimental physiology, experimental pathology, experimental pharmacology, new drug safety evaluation and medical device biological evaluation and efficacy degradation research. With the help of indirect research on animal models, it is possible to consciously change the Factors that may or are not easy to exclude, more accurate observation of model experiment results, and comparative studies with human diseases will help to understand the occurrence and development of human diseases more conveniently and effectively, and have an irreplaceable role in the study of disease prevention and control measures. Significance. [0003] Currently commonly used cerebral hemorrhage models include collagenase injection cerebral hemo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 何小华马玉奎张春霞程艳玲张琳琳郑晓霞韩磊
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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