59 results about "Brain meninges" patented technology

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.

In one embodiment, a method for performing meningeal repair includes closing an open meningeal defect with a human umbilical cord meningeal patch.

The application relates to the technical field of medical devices, and particularly discloses an expansion assembly for occipitoatlantoesthesis reconstruction, which comprises a plate body, one side of the plate body is provided with a groove, the plate body is provided with a plurality of first connecting parts, the first connecting parts are located on the outer periphery of the groove and are arranged at intervals, and the first connecting parts are used for being connected with the occipital bone and / or the atlas; the plate body is provided with at least one second connecting part, the second connecting part is arranged on the groove bottom, and the second connecting part is used for fixing the meninges. The above-mentioned arrangement is helpful for relieving the compression of the brain tissue and restoring the circulation of the cerebrospinal fluid. Since the plate body has the supporting capacity, when the intracranial pressure increases, the plate body will not be deformed, a relatively stable support is formed on the meninges, the probability of cracks at the suture of the meninges is reduced, the probability of the overflow of the cerebrospinal fluid and the meningeal outpouching is reduced, the recovery speed of the operation is improved, the scar adhesion is reduced, the circulation of the cerebrospinal fluid is smooth, and the probability of the secondary operation is reduced.

The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and / or repair.

The invention discloses a skull base dura mater stitching instrument, and relates to the technical field of medical instruments, the skull base dura mater stitching instrument comprises a tube body and a handle, one end of the tube body is provided with a stitching head, the stitching head is internally provided with a stitching seat, and the stitching head is internally provided with a clamping assembly facilitating stitching; a stapling assembly for suturing the dura mater is arranged in the suturing head; a driving assembly used for providing a power source for the clamping assembly is arranged in the sewing base. According to the endocranium suturing device, pre-stretching force is applied to the to-be-sutured area of the endocranium to form a tension gap, so that accurate penetration of suturing nails is facilitated, and the situation that the endocranium cannot be sutured effectively is avoided; suturing nails which are pushed to the pressing gap by the first spring in the storage groove can be pressed at a 90-degree vertical angle through the pressing roller, so that rapid and efficient suturing work on the dura mater is realized.

An implant assembly for accessing a dural venous sinus (DVS) in a cranial bone is configured to be received in a macroaperture created in the cranial bone adjacent an outer table thereof and in a connected microaperture of smaller diameter than the macroaperture created in the cranial bone and extending toward an inner table thereof. The implant assembly includes a bone anchor configured to be received in at least the macroaperture and having a lumen therethrough, and an implant body configured to be received in the lumen of the bone anchor and extend through the bone anchor into the microaperture, the implant body having a lumen for providing access therethrough to the DVS.

Bioadhesive and biodegradable polymeric nanoparticles can be administered intrathecally, for example, via the cisterna magna, into the spinal column to allow widespread distribution for the treatment of tumors such as leptomeningeal metastases. The nanoparticles rapidly spread to all cerebrospinal fluid (CSF) compartments, including the brain parenchyma and spinal column. The bioadhesive nanoparticles penetrate and are retained for long periods of time, during which time they can continue to release drugs. These nanoparticles can be loaded with different therapeutic, preventive, or diagnostic agents, most preferably DNA repair inhibitors, to enhance the killing of leptomeningeal tumors, such as leptomeningeal metastases, and disseminated tumors, such as medulloblastoma. In a preferred embodiment, patients are treated with a combination of a PARP inhibitor and temozolomide.

The present invention discloses a suturing device for the dura mater at the base of the skull, which relates to the technical field of medical devices and comprises a tube body and a handle. A suturing head is provided at one end of the tube body, a suturing seat is provided inside the suturing head, a clamping assembly for facilitating suturing is provided inside the suturing head; a stapling assembly for suturing the dura mater is provided inside the suturing head; and a driving assembly for providing a power source to the clamping assembly is provided inside the suturing seat. In the present invention, a pre-stretching force is applied to the area of ​​the dura mater to be sutured to form a tension gap, thereby facilitating the precise penetration of the suture staples and avoiding the situation where the dura mater cannot be effectively sutured. When the first gear sector is separated from the driven gear, the suture staples in the storage tank pushed to the compression gap by the first spring can be pressed together at a 90° vertical angle by the pressure roller, thereby achieving fast and efficient suturing of the dura mater.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The invention relates to a degradable manganous-manganic oxide-tannic acid-polymer composite modified artificial dura mater and preparation thereof, and belongs to the technical field of biological materials. According to the modified artificial dura mater, a spongy collagen biological membrane scaffold beneficial to cell growth and new dura mater tissue generation is provided for a dura mater defect part, and the modified artificial dura mater with good tissue compatibility and degradability is prepared by introducing carboxymethyl chitosan and manganous-manganic oxide / tannic acid. The novel composite artificial dura mater can effectively reduce intracranial infection and leakage of cerebrospinal fluid. The modified artificial dura mater loaded with the antioxidant manganous-manganic oxide / tannic acid nano-composite can effectively remove free radicals in the brain, and the composite modified artificial dura mater has anti-inflammatory and antibacterial functions and can be adhered to the surface of the dura mater after absorbing tissue exudate, water, buffer solution and the like. And can be tightly attached to the dura mater without suturing, and can exert antibacterial and anti-inflammatory activity for a long time.

The present disclosure provides a bioresorbable foam closure device for trans-nasally closing an opening in a base of a skull. The closure device comprises a phase-separated polymer. The device includes a stem portion having a proximal end and a distal end, and a head portion at the distal end of the stem portion. The closure device is deformed from a free shape to a constricted shape, inserted through a nasal cavity and into the opening, and released to at least partially revert back to the free shape such that the stem portion fills the opening and the head portion abuts cranium and dura to secure the closure device in position and seal the opening.

A dural venous sinus (DVS) implant anchor includes a body comprising a first portion extending in a first longitudinal direction, a second portion extending in a second longitudinal direction opposite the first longitudinal direction, and a connector portion coupled to the first portion and the second portion at an offset depth that corresponds to a depth of a first part of a thickness of a skull of a subject. When the DVS implant anchor is disposed within a DVS burr hole in the skull of the subject, the first portion extends along an outside surface of the skull and the second portion is at least partially disposed within the DVS burr hole.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

A method and apparatus introduced herein deploy a dura shield within a biological tissue during surgical procedures to protect the biological tissue. The method may comprise steps of puncturing a hole into the biological tissue at a desired location on the biological tissue by pushing a needle disposed within a cannula coupled to the housing, and pressing a button, coupled to an actuation plunger movably disposed within the housing, to cause forward movement of the actuation plunger, advance the dura shield guided by the cannula, and drive the dura shield through the hole.

The utility model relates to a positioning assembly which comprises a positioning optical filter, and criss-cross grid scale marks are arranged in the middle of the positioning optical filter. When the positioning optical filter is used, the positioning optical filter is installed on an interface base of a brain-computer interface device. According to the utility model, the positioning assembly is adopted to obtain a blood vessel distribution image, so that the blood vessel distribution under the dura mater is detected, and then the micro-needle assembly is adjusted, so that the multi-micro-needle one-time implantation is carried out by avoiding important blood vessel positions. Therefore, the position needing to avoid the blood vessel is accurately positioned by shooting the image and combining the grid scale marks on the positioning optical filter, so that the microneedle needing to be cut is judged. And then the microneedles at the corresponding positions are cut off, so that the aim of avoiding blood vessels under the dura mater when the microneedle array is integrally implanted is fulfilled, and the damage of the microneedles to brain tissues and the blood vessels is reduced as much as possible.

The invention discloses a universal suturing device suitable for dura mater and dura mater, and belongs to the technical field of medical instruments, the universal suturing device comprises a cylinder, an arc-shaped groove is formed in the front end in the cylinder, a suturing needle is inserted in the arc-shaped groove, a mounting groove is formed in the cylinder, a driving mechanism is arranged in the mounting groove, and the suturing needle is connected with the driving mechanism; and the driving mechanism is connected with a clamping mechanism. According to the universal suturing device suitable for the dura mater and the dura mater, the suturing requirements of two kinds of elastic tissues with different thicknesses can be met at the same time, and the applicability is high.

The invention belongs to the field of surgical traction equipment, and discloses clinical surgical traction equipment for the general surgery department, and the clinical surgical traction equipment is characterized in that a propelling assembly is slidably clamped in a sliding groove, and an elastic assembly is arranged at the upper end of the propelling assembly; when the propelling assembly moves to a scalp and skull adhesion area, the elastic assembly is pressed and contracted, and the bottom of the propelling assembly is kept in contact with the surface of the skull through the elastic assembly; when the propelling assembly moves to the skull sunken area, the elastic assembly restores elastically, and the elastic assembly presses the propelling assembly downwards, so that the bottom of the propelling assembly is attached to the bone surface of the sunken area; meanwhile, the propelling assembly is driven by the second rope to synchronously move in the direction close to the wound, the propelling assembly in linkage with a hook above is arranged below the wound, synchronous mechanical movement of pulling the wound and pushing out bone fragments is achieved through transmission of a pulley mechanism, the risk that the fragments move inwards to cause dura mater scratching is effectively reduced, and the safety of the dura mater is improved. And fragments can be concentrated to a surgical field center, so that quick cleaning is facilitated.

The present invention discloses the use of a lymphangiogenesis inducer. The lymphangiogenesis inducer can be used to treat neurotropic virus infections in an individual, especially viral encephalitis and inflammation-related central nerve damage. The lymphangiogenesis inducer can promote the generation and function of dural lymphatics, enhance lymphatic circulation, block excessive central nerve inflammatory responses, etc., thereby enhancing the body's resistance to lethal central nervous system virus infections, reducing viral encephalitis, and reducing damage to nerve cells and central nerve tissues. The present invention also discloses the use of monoclonal antibody Enbrel in the preparation of a drug for treating neurotropic virus infections in an individual, especially applicable to individuals with VEGFR-3 mutations or impaired brain lymphatic function.

In one embodiment, a method for performing meningeal repair includes closing an open meningeal defect with a human umbilical cord meningeal patch.

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

A stent device includes a single wire forming a braided body that extends between a proximal end and a distal end. The wire is formed of drawn filled tube (DFT). The braided body has a braid density in a range of 15 programmable picks per inch (PPI) to 34 PPI. The stent device is configured for implantation in a cerebral dural venous sinus and, when implanted, is configured to generate a chronic outward force sufficient to change blood flow within the cerebral dural venous sinus from pulsatile flow or turbulent flow to laminar flow.

The invention discloses an application of a Piezo1 agonist and a pharmaceutical preparation used for a nose, including an application of the Piezo1 agonist in preparation of a drug for promoting removal of cerebrospinal fluid and / or intracerebral metabolic waste through nasal tissues, and an application of the Piezo1 agonist in preparation of a drug for improving a nasal lymphatic vessel drainage function. The invention also provides a nasal drug delivery preparation containing the Yoda1. According to the invention, the Piezo1 agonist is proposed for the first time to eliminate A beta by improving the drainage function of nasal lymphatic vessels so as to improve cognitive and olfactory dysfunctions of the Alzheimer's disease, a nasal administration strategy is provided, and a new drug intervention direction is provided for AD treatment. The Yoda1 activates a signal channel of nasal lymphatic vessel Piezo1, not only can enhance the removal of A beta, but also can act on a meningelymphatic system through a nasal cavity-brain channel to further improve the metabolic balance of A beta in the brain, so that the Yoda1 has a relatively good clinical application prospect.

The invention provides an artificial dura mater material as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Aiming at the defects of the traditional artificially synthesized dura mater (spinal mater), the artificial dura mater (spinal mater) is processed by adopting the poly L-lactide-caprolactone (PLCL), adding the RAPA with a specific concentration and adopting an electrostatic spinning process, has the characteristics of low porosity and compact texture, and induces the rapid endothelialization of the dura mater in the early stage of craniocerebral trauma, and then, along with the release of the RAPA, the porosity of the material is increased, so that the endothelialization of the dura mater (spinal mater) in the early stage of craniocerebral trauma is improved. And proliferation and growth of new dura mater cells are facilitated. Meanwhile, the RAPA can prevent excessive proliferation of new endothelium and scar hyperplasia. Pathological proliferation can be selectively inhibited without damaging necessary lymphatic drainage; while the physical structure integrity of the dura mater is maintained, the nerve function repair can be promoted.

The invention discloses a collagen-based dura mater containing a specific microporous layer and a preparation method thereof. The collagen-based dura mater containing the specific microporous layer comprises a first collagen mater layer, a second collagen mater layer and a third collagen mater layer, wherein the first collagen mater layer is suitable for facing the skull side and at least comprises mineralized collagen materials; the first collagen membrane layer is suitable for facing the brain tissue side and at least comprises a second collagen membrane layer compounded by collagen and other materials; the microporous layer is located between the first collagen membrane layer and the second collagen membrane layer and at least comprises collagen, and the range of the pore diameter and the porosity of the microporous layer meets the requirements that the microporous layer is suitable for supporting growth and migration of meningeal cells, is also suitable for preventing leakage of cerebrospinal fluid and invasion of fibroblasts, and is also suitable for ensuring a continuous phase of mechanical support; the pore diameter of the microporous layer is 5-20 [mu] m, the porosity is 60-80%, and the thickness is 20-120 [mu] m. According to the technical scheme, a three-layer composite bionic structure is constructed by introducing the microporous layer with specific pore diameter and porosity between the two collagen membrane layers, so that cross-scale collaborative optimization of mechanical support, biological activity and anti-leakage performance of the dura mater repair material is realized.

A surgical device includes an elongated handle and at least one cutting assembly at an end of the handle. The at least one cutting assembly includes an elevator, a retainer located above the elevator, and at least one cutting blade positioned between the elevator and the retainer. The surgical device may be used to cut tissue, such as dura mater during brain surgery.

This invention provides an artificial dura mater material, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the shortcomings of traditional synthetic dura mater, this invention utilizes poly(L-lactide-caprolactone) (PLCL) with a specific concentration of RAPA, processed using electrospinning. It exhibits low porosity and a dense texture, inducing rapid endothelialization of the dura mater in the early stages of traumatic brain injury. Subsequently, with the release of RAPA, the material's porosity increases, facilitating the proliferation and growth of newly formed dura mater cells. Simultaneously, RAPA can prevent excessive proliferation of new endothelial cells and scar hyperplasia. It can selectively inhibit pathological proliferation without impairing necessary lymphatic drainage; while maintaining the physical structural integrity of the dura mater, it can promote neurological function repair.

The invention discloses a personalized bionic head face temporal bone surgery approach training system which comprises a 3D printing head face bionic model, a 3D printing temporal bone bionic model, a drill bit and a surgery navigation system. Four temporal bone operation approach sites are marked on the outer side face of the embedded 3D printing temporal bone bionic model; the inner side face of the 3D printing temporal bone bionic model is covered with a conductive coating, and the inner side face of the 3D printing temporal bone bionic model is further covered with a conductive copper foil used for simulating a dura mater structure. Facial nerves, facial arteries and facial veins which are made of silica gel materials are further arranged in the 3D printing temporal bone bionic model, and the outer surfaces of the facial nerves, the outer surfaces of the facial arteries and the outer surfaces of the facial veins are all coated with conductive coatings; when a drill bit touches facial nerves, facial arteries, facial veins and the inner side face and dura mater structure of the 3D printing temporal bone bionic model in the drilling and grinding process, the closed loop forms and generates alarm sound to prompt an operator. A temporal bone head and face bionic model suitable for teaching demonstration, head and neck neurosurgery operation training, preoperative planning and the like is constructed by utilizing a 3D printing technology and combining a real temporal bone structure.

1. Name of the product in this design: Soft tissue suture device. 2. Application of this design: for soft tissue suturing, especially suitable for transnasal skull base dura mater suturing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A stent device includes a single wire forming a braided body that extends between a proximal end and a distal end. The wire is formed of drawn filled tube (DFT). The braided body has a braid density in a range of 15 programmable picks per inch (PPI) to 34 PPI. The stent device is configured for implantation in a cerebral dural venous sinus and, when implanted, is configured to generate a chronic outward force sufficient to change blood flow within the cerebral dural venous sinus from pulsatile flow or turbulent flow to laminar flow.