59 results about "Brain meninges" patented technology

The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysaccharide processed to have the necessary strength characteristics, conformability and physical properties.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

The present invention provides a tissue repair scaffold and a preparation method and purpose thereof. The tissue repair scaffold comprises at least one composite fiber layer, and the composite fiber layer comprises a composite fiber formed by an adhesion factor and a hydrophobic synthetic material. The composite fiber layer may further form a porous three-dimensional mesh structure with a hydrophilic material. The tissue repair scaffold is applied to brain meninge repair, spinal meninge repair, a tissue engineering scaffold material, artificial skin, a wound assistant, a biological membrane, a wound cladding material, a hemostatic material, a postoperative adhesion prevention material, or a cosmetic material.

A shunt system for implantation of retrograde ventriculo-sinus shunts to establish a water tight connection that drains excess cerebrospinal fluid from hydrocephalic brain ventricles and delivers it, against the direction of blood flow, in a dural sinus comprising a valveless shunting catheter and a styforator. Retrograde ventriculo-sinus shunts mimic natural drainage of cerebrospinal fluid; they utilize natural forces to regulate the intraventricular pressure and to maintain it more than the sinus pressure, to prevent regurgitation of blood in the shunting catheter as a result of changes in posture or intra-thoracic pressure, to maintain a steady flow of cerebrospinal fluid to the venous circulation at a rate equal to and dependent upon the rate of it's formation, to discourage stagnation and clotting of blood at the venous end of the connection and to prevent siphonage in the erect posture.

The invention belongs to the technical field of medical instruments, and concretely relates to a skull drill. The skull drill comprises a guide rail, two ends of the guide rail are rotationally connected with rotating shafts, one ends, away from the guide rail, of the two rotating shafts are rotationally connected with first sliding blocks, the bottom ends of the first sliding blocks are movably connected with a sliding rail, a second sliding block is movably connected to the top of the guide rail, a first sleeve is fixed on the sidewall of the second sliding block, a push rod motor is fixed to the top end of the first sleeve, an electric drill is movably installed on the inner sidewall of the first sleeve, and the output shaft of the push rod motor is fixed to the top end of the electricdrill. The drilling depth of a drill bit is controlled through accurate stroke control of the push rod motor and auxiliary inspection of a pressure sensor, so the situation that contrary dura mater and brain tissue of a patient are injured by drilling due to failed control of the drilling depth during manual drilling is avoided, and therefore the success rate of an operation is increased.

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

The invention discloses a skull drill bit capable of stopping upon penetrating and a skull drill. The skull drill bit capable of stopping upon penetrating comprises a drill bit body, an amplitude-change pole, a connecting column, a reset spring, ejector heads, ejection head springs, elastic pins, an upper shell and a lower shell, wherein a center hole, a reset spring hole and a receding hole are sequentially formed in the connecting column; the reset spring is arranged in the reset spring hole; a disc part of the amplitude transformer is arranged in the receding hole and used for compressing the reset spring; a slender rod part of the amplitude-change pole is arranged in the center hole; the connecting column is further provided with a plurality of pin holes; ejection head holes communicating with the pin holes are formed in the end, close to the disc part, of the connecting column; the ejection heads are arranged in the ejection head holes; the ejection head springs are arranged in the pin holes; the elastic pins are arranged at the ends, away from the disc part, of the pin holes to press the ejection head springs; the drill bit is arranged at the end, close to the disc part, of the connecting column at an interval and provided with grooves matched with the tips of the ejection heads, and the connecting column and the drill bit are connected through the upper shell and the lower shell. When the drill bit drills through the skull, the drill bit stops rotating automatically, and the meninx is prevented from being injured when the drill bit drills through the skull.

The invention provides a polyethylene glycol-based adhesive. The polyethylene glycol-based adhesive is prepared from o-phthalaldehyde-terminated multi-arm polyethylene glycol and gelatin. According to the invention, phthalic dialdehyde-terminated polyethylene glycol (4armPEG-OPA) and a gelatin aqueous solution are cross-linked to form gel, and the gel is used for rapidly blocking and repairing damaged dura mater (dura mater and dura mater), so that cerebrospinal fluid leakage is prevented and treated, and epidural fibrosis is also prevented. The main raw materials polyethylene glycol and gelatin used in the invention have been approved by FDA for clinical use. The adhesive has good biocompatibility, biodegradability and good mechanical properties, has a low swelling rate, and does not cause the compression of tissue nerves.

A cranial implant for access to a cerebral cortex includes a window member shaped and dimensioned for positioning within a dural defect to provide access through the dura such that access to the cerebral cortex is provided in a location under study. An implant body is provided having a geometry that substantially conforms to a resected portion of a patient's anatomy to which the implant body is to be secured.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and / or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and / or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli. The subject's TVS and autonomic nervous system (ANS) are modulated in a manner that is effective to treat the subject for cerebral and ocular strokes. The invention, in some embodiments thereof, relates to a method for decreasing vascular resistance, enhancing vasodilatation in cerebral arteries, leptomeningeal collaterals and ophthalmic artery by the release of Vasoactive intestinal peptide (VIP),substance P and CGRP thereof increasing cerebral and / or OBF to the brain and the eye in subject's with acute dysregulated, reduced cerebral and / or OBF. The invention, in some embodiments thereof, is also relates to upregulation of TVS in a manner that is effective to induce acute development of leptomeningeal collateral circulation sufficient to ameliorate the ischemic effect of occluded cerebral artery, enhances successful recanalization, decreases the infarction volume and improves brain functional recovery without hemorrhagic transformation. In some embodiments TVS and ANS are also modulated in a manner that induce an acute increase in choroidal blood flow sufficient to ameliorate the ischemic effect of occluded artery until spontaneous recanalization of the occluded artery is accomplished. The invention is related to targeting the affected side via ipsilateral ONS without inducing intracerebral vascular steal phenomenon. The invention, in some embodiments thereof, is also relates to the methods for improving delivery of oxygen, glucose, anticoagulants, hormones, humoral mediators, growth factors and pharmacological agents to the targeted ischemic tissues of the brain, retina and optic nerve. The methods of the invention, when combined with r-tPA treatment and / or endovascular recanalization increases window time of treatment of stroke, enhance the efficacy of treatment and reduce its side effects. The methods of the invention, in some embodiments thereof, include priming of the brain, retina and / or optic nerve thereof to enhance the efficacy of cell transplantation therapy after exposure to stroke. Methods of the invention, in some embodiments thereof, may also include monitoring the subject for prophylactic treatment. The cerebral / and or OBF of subjects who had received neuromodulation treatment may also be monitored for re-treatment.

The invention provides a biologically-induced artificial dura mater and a preparation method thereof. The biologically-induced artificial dura mater has a dual-layer structure; a decellularized pig dermis scaffold is used as a substrate; and the decellularized pig dermis scaffold is uniformly coated by a collagen compound adhesive with excellent biocompatibility so as to form a film capable of preventing seepage of cerebrospinal fluids. The collagen fiber scaffold retains the three-dimensional structure of a natural matrix, maximally maintains a structure foundation, i.e., a three-strand spiral structure, capable of performing biological induction action, and guarantees biological activity. The collagen-based artificial dura mater prepared by using the method has excellent biocompatibility as collagen and good mechanical properties as decellularized pig dermis.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention belongs to the technical field of bio-based materials, and particularly relates to an artificial biological dura mater and a preparation method thereof. The artificial biological dura mater is prepared from the following raw materials of bacterial cellulose and collagen according to a mass ratio of (0.1 to 3):10; any crosslinking agent is not added, so that the adverse effect to therepair process of the dura mater by the crosslinking agent is reduced, and the clinical use safety of the dura mater product is improved. The artificial biological dura mater has the advantages that the artificial biological dura mater is prepared by an electrostatic spinning method; the pH (potential of hydrogen), temperature and other technology conditions are strictly controlled, so that the good biocompatibility and mechanical property are realized, the requirement of operation suture in the clinical use process is met, and the leakage of cerebrospinal fluid is effectively prevented.

The present invention addresses the problem of providing an evaluation model which enables evaluation of how much external force is being applied to intracerebral organs and / or the skull during endoscopic transnasal surgery. The problem can be solved by an evaluation model for endoscopic transnasal surgery, the model comprising a simulated head and a strain sensor, the simulated head including a simulated skull, the simulated skull including a simulated nasal cavity, the strain sensor being disposed at a part of the simulated head.