65 results about "Brain meninges" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair / regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

The invention comprises a surgically implantable hearing aid for hearing impaired persons. The hearing aid includes a vibrational element which is vibrated by sound waves and attached to the skull of the person, and a connector which crosses the mastoid cavity and delivers the sound waves to the dura mater of the human being thereby vibrating the dura mater, the cerebrospinal fluids, and the brain to create a hearing percept. The invention can also be adapted to act as a tinnitus masker or used in conjunction with a cochlear implant. It can also be used in a modified form to connect directly through the skull of the human being.

The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysaccharide processed to have the necessary strength characteristics, conformability and physical properties.

The invention discloses a biodegradable albumin hydrogel. According to the hydrogel, the gelling time is smaller than 20 seconds, the swelling degree is 50-200%, the burst strength is not lower than 10 kPa, and the degradation time in vitro is smaller than 30 days. Raw materials for preparation of the hydrogel comprise a first component albumin containing a nucleophilic functional group, a hydrophilic polymer containing multiple electrophilic functional groups and a second component of visual reagent mixture, and the two components are physically mixed through a double-component syringe and then undergo covalent crosslinking to form the hydrogel. The physical performance and biodegradable performance of the hydrogel can be regulated through a change of the second component, the naked-eye visibility of the hydrogel is good, and the hydrogel can be applicable to wound closure of different tissue parts in vivo, for example, closure of a celebral dura mater incision.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

The present invention provides a tissue repair scaffold and a preparation method and purpose thereof. The tissue repair scaffold comprises at least one composite fiber layer, and the composite fiber layer comprises a composite fiber formed by an adhesion factor and a hydrophobic synthetic material. The composite fiber layer may further form a porous three-dimensional mesh structure with a hydrophilic material. The tissue repair scaffold is applied to brain meninge repair, spinal meninge repair, a tissue engineering scaffold material, artificial skin, a wound assistant, a biological membrane, a wound cladding material, a hemostatic material, a postoperative adhesion prevention material, or a cosmetic material.

Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.

The invention provides an absorbable anastomosis lock nail and a lock nail holder. The anastomosis lock nail is used for repairing sella or basis cranii cerebral dura mater when treating sella lesion via a nasal transsphenoidal approach in neurosurgery or when used for neuroendoscopic surgery. The absorbable anastomosis lock nail comprises a lock head and a lock cap, the head end of the lock head is a three-rhombohedral-surface structure, a raised stopping portion is arranged on the inner wall of the lock cap, and the lock head penetrates through the stopping portion to be fixedly clamped in the lock cap when locking. The structure of the head end of the nail holder corresponds to the structure of the anastomosis lock nail, and the nail holder is provided with fixing grooves corresponding to the lock head and the lock cap. By the aid of the absorbable anastomosis lock nail, artificial cerebral dura mater or autologous fascia and an incised dura mater residual edge of the skull base of a patient can be completely repaired, various complications including cerebrospinal fluid, intracranial infection and the like which are caused by a present traditional method of filling biological glue and various filling materials into sella and sphenoid sinus are obviously reduced, and simultaneously, death rate caused by the complications is reduced.

A shunt system for implantation of retrograde ventriculo-sinus shunts to establish a water tight connection that drains excess cerebrospinal fluid from hydrocephalic brain ventricles and delivers it, against the direction of blood flow, in a dural sinus comprising a valveless shunting catheter and a styforator. Retrograde ventriculo-sinus shunts mimic natural drainage of cerebrospinal fluid; they utilize natural forces to regulate the intraventricular pressure and to maintain it more than the sinus pressure, to prevent regurgitation of blood in the shunting catheter as a result of changes in posture or intra-thoracic pressure, to maintain a steady flow of cerebrospinal fluid to the venous circulation at a rate equal to and dependent upon the rate of it's formation, to discourage stagnation and clotting of blood at the venous end of the connection and to prevent siphonage in the erect posture.

The invention belongs to the technical field of medical instruments, and concretely relates to a skull drill. The skull drill comprises a guide rail, two ends of the guide rail are rotationally connected with rotating shafts, one ends, away from the guide rail, of the two rotating shafts are rotationally connected with first sliding blocks, the bottom ends of the first sliding blocks are movably connected with a sliding rail, a second sliding block is movably connected to the top of the guide rail, a first sleeve is fixed on the sidewall of the second sliding block, a push rod motor is fixed to the top end of the first sleeve, an electric drill is movably installed on the inner sidewall of the first sleeve, and the output shaft of the push rod motor is fixed to the top end of the electricdrill. The drilling depth of a drill bit is controlled through accurate stroke control of the push rod motor and auxiliary inspection of a pressure sensor, so the situation that contrary dura mater and brain tissue of a patient are injured by drilling due to failed control of the drilling depth during manual drilling is avoided, and therefore the success rate of an operation is increased.

The invention relates to antibacterial leakproof endocranium repairing piece. The antibacterial leakproof endocranium repairing piece comprises a repairing layer and an antibacterial leakproof and antiblocking layer, wherein the antibacterial leakproof and antiblocking layer is tiled on the repairing layer. The leakproof and antiblocking layer of the antibacterial leakproof endocranium repairing piece can form a humid and smooth gelatin surface in bodies, the brain tissue can be protected, generation of blemish and epilepsy can be avoided, moist heal environment can be provided for wound parts, maintaining of cell viability is facilitated, and the healing of the wound parts is facilitated. The repairing layer is not cross-linked, so that a natural three-dimensional space structure is reserved, and cell ingrowth is facilitated. In addition, the antibacterial leakproof endocranium repairing piece is simple in preparation method, and can effectively prevent products from being polluted inthe processing course. The product quality is easy to control, the raw materials are broad in sources, the cost is low, and cost for mass production is reduced.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention discloses an absorbable dura mater and a preparation method thereof. The absorbable dura mater comprises a hydrophilic layer and a hydrophobic layer, wherein a three-dimensional structure formed by crosslinking and curing acrylic acid esterification gelatin and acrylate-polyethylene glycol-N-hydroxysuccinimide ester is used as the hydrophilic layer, and a compact film formed by absorbable polyester is used as the hydrophobic layer. The absorbable dura mater can achieve tissue regeneration of a dura mater defect part, can be quickly sealed with a defect edge, has high strength, can be effectively utilize the compact hydrophobic layer to prevent cerebrospinal fluid from leaking, and can effectively utilize the hydrophilic layer to accelerate regeneration of the dura mater defect area.

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

The invention provides a composite biological patch as well as a preparation method and an application thereof, and relates to the technical field of medical treatment. The composite biological patch provided by the invention comprises a hydrophobic porous layer, a compact layer and a porous scaffold, the hydrophobic porous layer is opposite to one side of a to-be-repaired tissue and is loaded with an anti-infection drug, the hydrophobicity of the hydrophobic porous layer and the loaded drug can be matched with each other, the drug can be slowly released, and the effects of prevention, anti-infection and anti-adhesion are achieved; the porous scaffold has a porous structure, faces one side of a to-be-repaired tissue, is beneficial to adhesion and growth of cells, and induces membrane tissue regeneration; the hydrophobic porous layer and the porous scaffold spacing compact layer can ensure the dimensional stability and mechanical strength of the product, and also can play a role of a barrier. The composite biological patch provided by the invention can be used for meninx repair, spinal meninx repair, rotator cuff repair, hernia repair, ophthalmology repair, breast repair, hemostasis repair or oral cavity repair.

An absorbable artificial dura mater of brain is prepared from glycerin, gelatin and the mixed solution of norfloxacin and 3% chitosan through coating the mixture on polylactate net or non-woven cloth by horizontal doctor blading or spraying, baking, neutrlizing, flushing with distilled water, immersion, drying cutting and sterilization to obtain a dual-layer artificial dura mater of brain. Its advantages include high biocompatibility, no poison, no antagon reaction and slow absorption. It can be used to repair human organs.

The invention provides polyethylene glycol based hydrogel. The polyethylene glycol based hydrogel is prepared through a reaction between a polyethylene glycol derivative and a dopamine derivative. Thehydrogel has excellent adhesiveness when used for meninges repair, a wound surface can quickly form gel, the stressed wound surface can be closed separately, the blocking capability is strong, and the hydrogel is quite suitable for clinical meninges repair. The polyethylene glycol based hydrogel is good in compactness and free of permeability, cerebrospinal fluid leakage can be prevented to wellprotect brain tissue, meninges-brain adhesion cannot occur, tissue compatibility is good, a rejection reaction is avoided, and acute or chronic inflammations cannot be caused; and meanwhile, the hydrogel is safe and nontoxic, does not propagate potential known or unknown infections, can degrade at a proper speed in a body and can be replaced by new tissue.

The invention discloses a skull drill bit capable of stopping upon penetrating and a skull drill. The skull drill bit capable of stopping upon penetrating comprises a drill bit body, an amplitude-change pole, a connecting column, a reset spring, ejector heads, ejection head springs, elastic pins, an upper shell and a lower shell, wherein a center hole, a reset spring hole and a receding hole are sequentially formed in the connecting column; the reset spring is arranged in the reset spring hole; a disc part of the amplitude transformer is arranged in the receding hole and used for compressing the reset spring; a slender rod part of the amplitude-change pole is arranged in the center hole; the connecting column is further provided with a plurality of pin holes; ejection head holes communicating with the pin holes are formed in the end, close to the disc part, of the connecting column; the ejection heads are arranged in the ejection head holes; the ejection head springs are arranged in the pin holes; the elastic pins are arranged at the ends, away from the disc part, of the pin holes to press the ejection head springs; the drill bit is arranged at the end, close to the disc part, of the connecting column at an interval and provided with grooves matched with the tips of the ejection heads, and the connecting column and the drill bit are connected through the upper shell and the lower shell. When the drill bit drills through the skull, the drill bit stops rotating automatically, and the meninx is prevented from being injured when the drill bit drills through the skull.

The invention provides a polyethylene glycol-based adhesive. The polyethylene glycol-based adhesive is prepared from o-phthalaldehyde-terminated multi-arm polyethylene glycol and gelatin. According to the invention, phthalic dialdehyde-terminated polyethylene glycol (4armPEG-OPA) and a gelatin aqueous solution are cross-linked to form gel, and the gel is used for rapidly blocking and repairing damaged dura mater (dura mater and dura mater), so that cerebrospinal fluid leakage is prevented and treated, and epidural fibrosis is also prevented. The main raw materials polyethylene glycol and gelatin used in the invention have been approved by FDA for clinical use. The adhesive has good biocompatibility, biodegradability and good mechanical properties, has a low swelling rate, and does not cause the compression of tissue nerves.

A cranial implant for access to a cerebral cortex includes a window member shaped and dimensioned for positioning within a dural defect to provide access through the dura such that access to the cerebral cortex is provided in a location under study. An implant body is provided having a geometry that substantially conforms to a resected portion of a patient's anatomy to which the implant body is to be secured.

A dural knife is provided with a handle, protector, and cutting element, wherein the protector is connected to one end of the handle and the cutting element connects to both the handle and the protector. More particularly, the dural knife has a protector shape and blade height that is adapted to safely raising the dura away from the cortex and making an incision in the dura while sliding the protector beneath the dura.

The invention relates to a transnasal nerve skull base repair device, a skull base repair membrane and a using method of the device. The transnasal nerve skull base repair device comprises a first repair membrane assembly used for repairing a liliequist membrane ventage and a second repair membrane assembly used for repairing a dura mater ventage. According to the transnasal nerve skull base repairing device, the skull base repairing membrane and the using method of the device, through cooperative use of the fusible biological membrane, the non-fusible biological membrane, the supporting piece, the hemostatic yarn and the fixing air bag, the technical scheme is compact in structure, high in clinical practicability and remarkable in effect; the skull base repair is successfully realized, the occurrence of postoperative complication cerebrospinal fluid leakage of the transnasal neuroendoscopy is prevented, the risk of intracranial infection is reduced, the possibility of endangering the life of a patient is reduced, the life quality of the patient is improved, and the prognosis is improved; in addition, artificial materials are adopted in the repairing process of the method.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and / or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and / or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli. The subject's TVS and autonomic nervous system (ANS) are modulated in a manner that is effective to treat the subject for cerebral and ocular strokes. The invention, in some embodiments thereof, relates to a method for decreasing vascular resistance, enhancing vasodilatation in cerebral arteries, leptomeningeal collaterals and ophthalmic artery by the release of Vasoactive intestinal peptide (VIP),substance P and CGRP thereof increasing cerebral and / or OBF to the brain and the eye in subject's with acute dysregulated, reduced cerebral and / or OBF. The invention, in some embodiments thereof, is also relates to upregulation of TVS in a manner that is effective to induce acute development of leptomeningeal collateral circulation sufficient to ameliorate the ischemic effect of occluded cerebral artery, enhances successful recanalization, decreases the infarction volume and improves brain functional recovery without hemorrhagic transformation. In some embodiments TVS and ANS are also modulated in a manner that induce an acute increase in choroidal blood flow sufficient to ameliorate the ischemic effect of occluded artery until spontaneous recanalization of the occluded artery is accomplished. The invention is related to targeting the affected side via ipsilateral ONS without inducing intracerebral vascular steal phenomenon. The invention, in some embodiments thereof, is also relates to the methods for improving delivery of oxygen, glucose, anticoagulants, hormones, humoral mediators, growth factors and pharmacological agents to the targeted ischemic tissues of the brain, retina and optic nerve. The methods of the invention, when combined with r-tPA treatment and / or endovascular recanalization increases window time of treatment of stroke, enhance the efficacy of treatment and reduce its side effects. The methods of the invention, in some embodiments thereof, include priming of the brain, retina and / or optic nerve thereof to enhance the efficacy of cell transplantation therapy after exposure to stroke. Methods of the invention, in some embodiments thereof, may also include monitoring the subject for prophylactic treatment. The cerebral / and or OBF of subjects who had received neuromodulation treatment may also be monitored for re-treatment.

The invention discloses a skull implant, which comprises an implant main body, which is provided with an upper surface and a lower surface which are opposite to each other; the implant body comprises an upper surface and at least one micro-channel structure formed in the implant body, and each micro-channel structure is provided with at least one communication channel communicated with a first position of the upper surface and a second position of the upper surface. In an operation, after the implant is installed in the cranium of a patient, the upper surface of the implant body faces the scalp flap soft tissue, the lower surface of the implant body faces the dura mater soft tissue, and particularly, the implant for skull repair provides a growth channel for biological tissue in a mode of constructing a micro-pore channel structure; therefore, the combination mode of the implant for skull repair and intracranial tissues is optimized.

The invention provides a biologically-induced artificial dura mater and a preparation method thereof. The biologically-induced artificial dura mater has a dual-layer structure; a decellularized pig dermis scaffold is used as a substrate; and the decellularized pig dermis scaffold is uniformly coated by a collagen compound adhesive with excellent biocompatibility so as to form a film capable of preventing seepage of cerebrospinal fluids. The collagen fiber scaffold retains the three-dimensional structure of a natural matrix, maximally maintains a structure foundation, i.e., a three-strand spiral structure, capable of performing biological induction action, and guarantees biological activity. The collagen-based artificial dura mater prepared by using the method has excellent biocompatibility as collagen and good mechanical properties as decellularized pig dermis.

The invention discloses a dura-puncturing trocar and a support handle thereof. The dura-puncturing trocar is composed of integration of a cylindrical portion at the lower end and a triangular blade-shaped conical head at the upper end. The cross section of the triangular blade-shaped conical head is of a triangular tip shape, and the triangular blade-shaped conical head is formed by connection oftails of three triangular small blades. A junction of the three triangular small blades constitutes a blunt-tip portion in 0.5mm diameter. According to the present invention, the dura-puncturing trocar cooperates with a traditional meninx-puncturing trocar to puncture dura, thereby avoiding damage of blood vessels on a brain surface, and a support limit handle of the dura-puncturing trocar can bequickly assembled and used to quickly adjust length of the conical head, so that the dura-puncturing trocar is simple, convenient, and easy to disinfect and store.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention belongs to the technical field of bio-based materials, and particularly relates to an artificial biological dura mater and a preparation method thereof. The artificial biological dura mater is prepared from the following raw materials of bacterial cellulose and collagen according to a mass ratio of (0.1 to 3):10; any crosslinking agent is not added, so that the adverse effect to therepair process of the dura mater by the crosslinking agent is reduced, and the clinical use safety of the dura mater product is improved. The artificial biological dura mater has the advantages that the artificial biological dura mater is prepared by an electrostatic spinning method; the pH (potential of hydrogen), temperature and other technology conditions are strictly controlled, so that the good biocompatibility and mechanical property are realized, the requirement of operation suture in the clinical use process is met, and the leakage of cerebrospinal fluid is effectively prevented.