27 results about "Brain meninges" patented technology

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.

The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and / or repair.

An implant assembly for accessing a dural venous sinus (DVS) in a cranial bone is configured to be received in a macroaperture created in the cranial bone adjacent an outer table thereof and in a connected microaperture of smaller diameter than the macroaperture created in the cranial bone and extending toward an inner table thereof. The implant assembly includes a bone anchor configured to be received in at least the macroaperture and having a lumen therethrough, and an implant body configured to be received in the lumen of the bone anchor and extend through the bone anchor into the microaperture, the implant body having a lumen for providing access therethrough to the DVS.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The invention relates to a degradable manganous-manganic oxide-tannic acid-polymer composite modified artificial dura mater and preparation thereof, and belongs to the technical field of biological materials. According to the modified artificial dura mater, a spongy collagen biological membrane scaffold beneficial to cell growth and new dura mater tissue generation is provided for a dura mater defect part, and the modified artificial dura mater with good tissue compatibility and degradability is prepared by introducing carboxymethyl chitosan and manganous-manganic oxide / tannic acid. The novel composite artificial dura mater can effectively reduce intracranial infection and leakage of cerebrospinal fluid. The modified artificial dura mater loaded with the antioxidant manganous-manganic oxide / tannic acid nano-composite can effectively remove free radicals in the brain, and the composite modified artificial dura mater has anti-inflammatory and antibacterial functions and can be adhered to the surface of the dura mater after absorbing tissue exudate, water, buffer solution and the like. And can be tightly attached to the dura mater without suturing, and can exert antibacterial and anti-inflammatory activity for a long time.

The present disclosure provides a bioresorbable foam closure device for trans-nasally closing an opening in a base of a skull. The closure device comprises a phase-separated polymer. The device includes a stem portion having a proximal end and a distal end, and a head portion at the distal end of the stem portion. The closure device is deformed from a free shape to a constricted shape, inserted through a nasal cavity and into the opening, and released to at least partially revert back to the free shape such that the stem portion fills the opening and the head portion abuts cranium and dura to secure the closure device in position and seal the opening.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

The invention discloses a collagen-based dura mater containing a specific microporous layer and a preparation method thereof. The collagen-based dura mater containing the specific microporous layer comprises a first collagen mater layer, a second collagen mater layer and a third collagen mater layer, wherein the first collagen mater layer is suitable for facing the skull side and at least comprises mineralized collagen materials; the first collagen membrane layer is suitable for facing the brain tissue side and at least comprises a second collagen membrane layer compounded by collagen and other materials; the microporous layer is located between the first collagen membrane layer and the second collagen membrane layer and at least comprises collagen, and the range of the pore diameter and the porosity of the microporous layer meets the requirements that the microporous layer is suitable for supporting growth and migration of meningeal cells, is also suitable for preventing leakage of cerebrospinal fluid and invasion of fibroblasts, and is also suitable for ensuring a continuous phase of mechanical support; the pore diameter of the microporous layer is 5-20 [mu] m, the porosity is 60-80%, and the thickness is 20-120 [mu] m. According to the technical scheme, a three-layer composite bionic structure is constructed by introducing the microporous layer with specific pore diameter and porosity between the two collagen membrane layers, so that cross-scale collaborative optimization of mechanical support, biological activity and anti-leakage performance of the dura mater repair material is realized.

A surgical device includes an elongated handle and at least one cutting assembly at an end of the handle. The at least one cutting assembly includes an elevator, a retainer located above the elevator, and at least one cutting blade positioned between the elevator and the retainer. The surgical device may be used to cut tissue, such as dura mater during brain surgery.

This invention provides an artificial dura mater material, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the shortcomings of traditional synthetic dura mater, this invention utilizes poly(L-lactide-caprolactone) (PLCL) with a specific concentration of RAPA, processed using electrospinning. It exhibits low porosity and a dense texture, inducing rapid endothelialization of the dura mater in the early stages of traumatic brain injury. Subsequently, with the release of RAPA, the material's porosity increases, facilitating the proliferation and growth of newly formed dura mater cells. Simultaneously, RAPA can prevent excessive proliferation of new endothelial cells and scar hyperplasia. It can selectively inhibit pathological proliferation without impairing necessary lymphatic drainage; while maintaining the physical structural integrity of the dura mater, it can promote neurological function repair.

1. Name of the product in this design: Soft tissue suture device. 2. Application of this design: for soft tissue suturing, especially suitable for transnasal skull base dura mater suturing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The utility model provides a kind of aseptic neurosurgery dura mater hook needle, including needle body, the needle body is crescent structure, needle body's head is sharp, needle body's tail end is connected to pull holding part;The inside of the needle body is equipped with limiting portion, the limiting portion is the crescent structure that is arranged with needle body arc shape parallel interval, the head of limiting portion is round blunt, the tail end of limiting portion is fixedly connected with needle body;The distance between the head of the limiting portion and the head of needle body is less than the thickness of dura mater, the spacing between the limiting portion and needle body is less than the thickness of dura mater.When being punctured and pulled by the head of needle body to dura mater, on the one hand, the head of limiting portion will play the role of blocking and limiting to dura mater, avoid the head of needle body to puncture and injure the brain tissue under dura mater, on the other hand, since the spacing between the limiting portion and needle body is less than the thickness of dura mater, the part of dura mater after puncture will enter between needle body and limiting portion, can completely avoid dura mater to be punctured, reach the purpose of protecting the brain tissue under.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The invention relates to an implant (1) for treating a defect, in particular for replacement and / or closure, of the dura mater. The implant (1) comprises a layer (2) with recombinant collagen and a fiber layer (3).

This utility model relates to the field of medical device technology, specifically to a device including a fixed titanium clip. The back of the fixed titanium clip is provided with a medical clamp for holding the clip, and the end of the medical clamp is provided with a slot for restricting the fixed titanium clip. This device adds an auxiliary opening and closing component, into which the end of the medical clamp extends to one end of the auxiliary opening and closing component, fixing the fixed titanium clip to the other end of the auxiliary opening and closing component. This changes the way the medical clamp opens and closes to fix the titanium clip, further improving the practicality of the device.

The invention relates to an implant (1) for treating a defect, in particular for replacing and / or closing, of the dura mater. The implant (1) comprises a layer (2) with recombinant collagen and a fibrous layer (3).

The invention discloses a multi-layer degradable artificial meninx repair stent and a preparation method thereof, the artificial meninx repair stent main body is of a three-layer structure, the inner layer is a directional nanofiber antibacterial layer, the middle layer is a disordered nanofiber leakage-proof layer, and the outer layer is a porous micron fiber layer with bone regeneration activity. The multi-level degradable artificial meninx repair stent designed by the invention can realize sustainable release of drugs, has the effects of promoting nerve repair and effectively preventing leakage of cerebrospinal fluid, and has blood compatibility and biocompatibility; the polypeptide has the characteristic of promoting osteogenesis, and has important application in wound healing, adhesion prevention and nerve repair tissue engineering.

The invention belongs to the technical field of biomedical materials, and discloses preparation of a low-swelling medical tissue sealant and application of the low-swelling medical tissue sealant in dura mater repair. The invention discloses a sealant. The sealant is prepared from the following raw materials: multi-arm polyethylene glycol active ester and aminated gelatin. The invention provides a sealant. The sealant is formed by crosslinking multi-arm polyethylene glycol active ester and aminated gelatin through amido bonds. The sealant has the advantages of rapid gelling, high mechanical strength, strong tissue adhesion, ultralow swelling ratio, controllable degradation and excellent biocompatibility. The sealant can realize in-situ sealing and repairing of dura mater injury and prevent leakage of cerebrospinal fluid, has antibacterial, anti-infection and nerve protection effects, is suitable for repairing of dura mater and dura mater, and is especially suitable for minimally invasive neurosurgery.

The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

The application discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. First, based on individual structural magnetic resonance images, a personalized six-layer brain tissue dissection model containing the cortex, white matter, cerebrospinal fluid, dura mater, skull and scalp is constructed, and differentiated conductivity parameters are given. Second, neurophysiological prior knowledge such as neural dynamics and white matter anisotropic conduction is converted into a representation rule that can be learned by a neural network. Then, these rules are embedded in the physical information neural network in the form of differentiable physical constraints, including the residual error of the cortical neural dynamics equation, the residual error of the volume conduction equation of each layer, and the continuity constraint of the interlayer interface. Finally, the scalp electroencephalogram signal is used to train the network, and by minimizing the loss function containing the reconstruction and physical constraints, a high-fidelity intracranial electroencephalogram signal and multi-modal neurophysiological information are jointly output. The application effectively improves the fidelity, physical reasonableness and clinical interpretability of signal enhancement.

The invention provides an implantable epidural brain-computer interface electrode and a preparation method thereof.The electrode comprises a first packaging layer, a bottom layer, a metal layer, a top layer, a modification layer and a second packaging layer which are sequentially arranged from bottom to top, an electrode point area of the metal layer is of a Laplace structure, and an electrode point is connected with a metal layer bonding pad through a snakelike metal wire; the bottom layer bonding pad area is provided with a first windowing structure, and the top layer electrode point area is provided with a second windowing structure; the bottom layer snakelike line area and the top layer snakelike line area are provided with paper-cut structures. The modification layer is in contact with the outer side of the dura mater, so that tissue-electrode contact impedance is reduced; a third windowing structure is arranged at the position, corresponding to the metal layer bonding pad, of the first packaging layer, and the first packaging layer is in direct contact with the tissue fluid; a fourth windowing structure is arranged at the position, corresponding to the electrode point, of the second packaging layer, and the second packaging layer is in direct contact with the dura mater and tissue fluid. The spatial precision of signal acquisition of the electrode and the flexibility and stretchability of the electrode are improved, and long-term implantation is facilitated.

The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and / or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor.

This invention relates to the field of medical repair materials technology, and discloses a self-adhesive artificial dura mater and its preparation method. The dura mater comprises a repair layer, an adhesive layer, and a protective layer sequentially composited from the inside out. The repair layer is made by mixing collagen, hyaluronic acid, and polycaprolactone in a specific mass ratio. The adhesive layer of this self-adhesive artificial dura mater is made by mixing a cell-free matrix, chitosan, and medical-grade polyacrylate in a specific ratio. The surface is plasma-treated to form a micro-roughened structure, exhibiting good adhesion at room temperature. It can tightly adhere to the edge tissue of dura mater defects. The self-adhesive design eliminates the need for additional sutures, staples, or other fixation operations, simplifying the surgical procedure, shortening the operation time, and reducing the difficulty of the surgeon's operation. This effectively shortens the operation time. Simultaneously, the adhesive layer forms a tight interface with the tissue, effectively sealing the defect edge, reducing postoperative cerebrospinal fluid leakage, material displacement, and the resulting infection risk, thus improving the safety and success rate of the surgery.

Disclosed in the present invention is an ultrasonic stimulation system for targeted enhancement of collateral circulation for the treatment of ischemic stroke. The system comprises: an ultrasonic stimulation module for generating non-invasive low-frequency ultrasonic waves to stimulate nerves in a specific region on the brain surface, so as to promote the dilation of pial arteries, thereby enhancing the retrograde blood supply of the collateral circulation; a sensor module for monitoring cerebral blood flow changes in real time and uploading a monitoring result to a control module; and the control module for issuing a corresponding control instruction to the ultrasonic stimulation module according to the monitoring result uploaded by the sensor module, so as to adjust parameters of the low-frequency ultrasonic waves output by the ultrasonic stimulation module. The LIPUS technology can act directly on the scalp surface without anesthesia and surgical operations. The LIPUS technology can act directly on the peripheral terminals of trigeminal ganglion neurons around the pial arteries to dilate the local arteries; the range of action is accurate and limited, and the local blood flow velocity is directly accelerated. The functional near-infrared spectroscopy technology is further combined to monitor the cerebral blood flow changes in real time, thus improving the safety and effects of treatment.