11 results about "Brain meninges" patented technology

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

This invention provides an artificial dura mater material, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the shortcomings of traditional synthetic dura mater, this invention utilizes poly(L-lactide-caprolactone) (PLCL) with a specific concentration of RAPA, processed using electrospinning. It exhibits low porosity and a dense texture, inducing rapid endothelialization of the dura mater in the early stages of traumatic brain injury. Subsequently, with the release of RAPA, the material's porosity increases, facilitating the proliferation and growth of newly formed dura mater cells. Simultaneously, RAPA can prevent excessive proliferation of new endothelial cells and scar hyperplasia. It can selectively inhibit pathological proliferation without impairing necessary lymphatic drainage; while maintaining the physical structural integrity of the dura mater, it can promote neurological function repair.

The invention relates to an implant (1) for treating a defect, in particular for replacement and / or closure, of the dura mater. The implant (1) comprises a layer (2) with recombinant collagen and a fiber layer (3).

This utility model relates to the field of medical device technology, specifically to a device including a fixed titanium clip. The back of the fixed titanium clip is provided with a medical clamp for holding the clip, and the end of the medical clamp is provided with a slot for restricting the fixed titanium clip. This device adds an auxiliary opening and closing component, into which the end of the medical clamp extends to one end of the auxiliary opening and closing component, fixing the fixed titanium clip to the other end of the auxiliary opening and closing component. This changes the way the medical clamp opens and closes to fix the titanium clip, further improving the practicality of the device.

The invention relates to an implant (1) for treating a defect, in particular for replacing and / or closing, of the dura mater. The implant (1) comprises a layer (2) with recombinant collagen and a fibrous layer (3).

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and / or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor.

This invention relates to the field of medical repair materials technology, and discloses a self-adhesive artificial dura mater and its preparation method. The dura mater comprises a repair layer, an adhesive layer, and a protective layer sequentially composited from the inside out. The repair layer is made by mixing collagen, hyaluronic acid, and polycaprolactone in a specific mass ratio. The adhesive layer of this self-adhesive artificial dura mater is made by mixing a cell-free matrix, chitosan, and medical-grade polyacrylate in a specific ratio. The surface is plasma-treated to form a micro-roughened structure, exhibiting good adhesion at room temperature. It can tightly adhere to the edge tissue of dura mater defects. The self-adhesive design eliminates the need for additional sutures, staples, or other fixation operations, simplifying the surgical procedure, shortening the operation time, and reducing the difficulty of the surgeon's operation. This effectively shortens the operation time. Simultaneously, the adhesive layer forms a tight interface with the tissue, effectively sealing the defect edge, reducing postoperative cerebrospinal fluid leakage, material displacement, and the resulting infection risk, thus improving the safety and success rate of the surgery.