Absorbable dura mater and preparation method thereof

A dura mater and gelatin technology, applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of prolonging postoperative recovery of patients, unable to provide cell adhesion, proliferation and differentiation, avoiding manual suture and shortening clinical operation time. , enhance the regeneration effect

Pending Publication Date: 2020-12-22
CHENGDU MEDART MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it can achieve effective bonding with brain tissue, the material itself cannot provide a site for cell adhesion, proliferation, and differentiation, and the hydrophilic layer does not have the ability to automatically bond with the dura mater at the edge of the defect, and it also needs to be sutured. It also prolongs the patient's postoperative recovery

Method used

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  • Absorbable dura mater and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] An absorbable dura mater, including a hydrophilic layer and a hydrophobic layer. The three-dimensional structure formed by the cross-linking and curing of acrylated gelatin and acrylate-polyethylene glycol-N hydroxysuccinimide ester is used as the hydrophilic layer. A dense film formed by absorbent polyester acts as a hydrophobic layer.

[0034] The preparation method of the absorbable dura mater described in this embodiment comprises the following steps:

[0035] S1. Add acrylated gelatin, acrylate-polyethylene glycol-N hydroxysuccinimide ester and photoinitiator into 400 parts by mass of deionized water according to parts by mass of 30, 20, and 0.5 parts by mass, stir and dissolve, and prepare A solution;

[0036] S2. Transfer the A solution to a flat mold C with a diameter of 15 cm and a thickness of 2 mm, and irradiate with a curing lamp with a wavelength of 420 nm to cross-link and solidify the A solution to form a hydrogel A;

[0037] S3. Freeze-drying the hydrog...

Embodiment 2

[0042] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:

[0043]The acrylated gelatin is butyl acrylated gelatin, and the acrylate-polyethylene glycol-N hydroxysuccinimide ester is methacrylate-PEG 1200 -N hydroxysuccinimide ester, the absorbable polyester is racemic polylactic acid, and the initiator is blue light initiator phenyl-2,4,6 trimethylbenzoyl lithium phosphite (LAP).

[0044] The mass ratio of acrylated gelatin, acrylate-polyethylene glycol-N hydroxysuccinimide ester photoinitiator and deionized water in step S1 is: 20:8:0.05:100;

[0045] The mass ratio of absorbable polyester to methylene chloride in step S4 is 40:200.

Embodiment 3

[0047] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:

[0048] The ethacrylated gelatin, the acrylate-polyethylene glycol-N hydroxysuccinimide ester is methacrylate-PEG 2000 -N hydroxysuccinimide ester, the absorbable polyester is a lactide / glycolide copolymer, and the initiator is a visible light initiator camphorquinone (CQ).

[0049] The mass ratio of acrylated gelatin, acrylate-polyethylene glycol-N hydroxysuccinimide ester photoinitiator and deionized water in step S1 is: 45:30:0.2:350;

[0050] The mass ratio of absorbable polyester to methylene chloride in step S4 is 15:80.

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Abstract

The invention discloses an absorbable dura mater and a preparation method thereof. The absorbable dura mater comprises a hydrophilic layer and a hydrophobic layer, wherein a three-dimensional structure formed by crosslinking and curing acrylic acid esterification gelatin and acrylate-polyethylene glycol-N-hydroxysuccinimide ester is used as the hydrophilic layer, and a compact film formed by absorbable polyester is used as the hydrophobic layer. The absorbable dura mater can achieve tissue regeneration of a dura mater defect part, can be quickly sealed with a defect edge, has high strength, can be effectively utilize the compact hydrophobic layer to prevent cerebrospinal fluid from leaking, and can effectively utilize the hydrophilic layer to accelerate regeneration of the dura mater defect area.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to an absorbable dura mater and a preparation method thereof. Background technique [0002] During neurosurgical craniotomy, the dura mater must be incised. Dural hemorrhage, electrocoagulation to stop bleeding, resection of tumor invasion into the dura mater, and traumatic dura mater injury can all lead to dural defect. If the dural defect caused by different reasons is not repaired in time, it will cause complications such as cerebrospinal fluid leakage, intracranial infection, encephalocele, brain adhesion and epilepsy. Therefore, in order to protect brain tissue, artificial dura mater materials have become the main treatment for clinical dural defect repair. [0003] At present, clinically available dural repair materials are mainly divided into: absorbable and non-absorbable. Absorbable is divided into animal collagen film and artificial synthetic material film. Although...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/22A61L27/18A61L27/40
CPCA61L27/58A61L27/50A61L27/222A61L27/18A61L2430/32C08L67/04C08L71/02
Inventor 杨满张晓金王军
Owner CHENGDU MEDART MEDICAL SCI CO LTD
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