31 results about "Dura mater encephali" patented technology

The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysaccharide processed to have the necessary strength characteristics, conformability and physical properties.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

The present invention relates to a dural sealing system (100) comprising: an implant (10) joined to a guiding wire (20); a transfer device (30) provided with a gripping portion (30a) and a hollow portion (30b), one end of the hollow portion (30b) ending in a nozzle (30c) couplable to an epidural needle (200), and the second end of said hollow portion (30b) being provided with an entry region (30d); and an introducer device (70) comprising a tube (70a) that has a hollow interior section and is provided with a first free end and a second closed end fixed to a stop (70b).

The invention relates to a method for manufacturing a head hierarchical dissection three-dimensional scanning specimen. The method comprises the following steps: selecting materials; sequentially removing skin, superficial fascia, latissimus jugular muscle, parotid gland, superficial vascular nerve, cap aponeurosis, masseter, periosteum and temporal muscle, opening zygomatic arch and mandible, removing sternoclavicular mastoid muscle, parietal bone of cranial top, frontal bone, temporal bone and occipital bone, cutting to open superior sagittal sinus, removing dura mater, brain, mandible, zygomatic major muscle, zygomatic minor muscle, orbiculus oculi muscle, trapezius muscle, capsid muscle, diabdominal muscle, deorbital horn muscle cheekbone, endocranium, and veins, removing styloid process tongue bone muscles, external rectus, arteries, styloid process pharynx muscles and styloid process tongue muscles, removing auricles, opening temporal bones, and performing median sagittal incision; then, trimming and cleaning the dissected specimen, and pasting specimen muscles, blood vessels and nerves to the original corresponding positions; and finally, combining and processing the 3D scanned images into a complete digital 3D model, so that the scanned specimen is complete in shape and structure, free switching can be realized, and observation and learning are facilitated.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention belongs to the technical field of bio-based materials, and particularly relates to an artificial biological dura mater and a preparation method thereof. The artificial biological dura mater is prepared from the following raw materials of bacterial cellulose and collagen according to a mass ratio of (0.1 to 3):10; any crosslinking agent is not added, so that the adverse effect to therepair process of the dura mater by the crosslinking agent is reduced, and the clinical use safety of the dura mater product is improved. The artificial biological dura mater has the advantages that the artificial biological dura mater is prepared by an electrostatic spinning method; the pH (potential of hydrogen), temperature and other technology conditions are strictly controlled, so that the good biocompatibility and mechanical property are realized, the requirement of operation suture in the clinical use process is met, and the leakage of cerebrospinal fluid is effectively prevented.

The invention provides a multilayer anti-infection high-strength artificial dura mater, which comprises three layers including a hydrophobic inner layer facing to the cerebrum, a water-soluble chitosan outer layer backing to the cerebrum and a woven type middle layer. The invention also provides a preparation method of the multilayer anti-infection high-strength artificial dura mater. The preparation method comprises the following steps of preparing the hydrophobic inner layer through electrospinning; preparing water-soluble chitosan fine strips; preparing hydrophobic fine strips; preparing the woven type middle layer; preparing the outer layer on the middle layer by an oriented electrospinning process; finally obtaining the artificial dura mater. The artificial dura mater effectively solves the problem of infection in the dura mater repair process; meanwhile, the strength of the traditional artificial dura mater is improved; free cutting can be performed according to requirements; safety and reliability are realized; the application prospects are wide.

The invention provides a dura graft and a preparation method thereof. The dura graft is prepared from an acellular dermal matrix. The acellular dermal matrix is obtained from allogenic skin by crosslinking treatment, digestion treatment with a protease solution, decellularization with a hypertonic saline solution containing a surfactant, DNA degradation, amino acid nutrition treatment and freeze drying. The invention also provides applications of the dura graft in preparing repair materials used in the treatment of dural damage. The acellular dermal matrix is obtained from human skin tissue and undergoes physicochemical and biochemical treatment, so that all the components that may cause immunological rejection are removed. A fibrous stereoscopic scaffold structure of the original tissue is completely reserved, and new vessels and fibroblasts rapidly grow in the dura graft after implantation. Therefore, the dura graft has good clinical effects.

The invention discloses a double-layer artificial dura mater and a manufacturing method thereof and belongs to the technical field of medical product manufacturing. The double-layer artificial dura mater is composed of two layers of pig-derived pericardium and polydimethylsiloxane bonded with the two layers of pig-derived pericardium. The preparation method of the double-layer artificial dura mater comprises the following steps that a polydimethylsiloxane solution A and a polydimethylsiloxane solution B are mixed, bubbles are removed, the mixture is arranged between two layers of pig-derived pericardium in a coating mode, after bonding, and the pig-derived pericardium is cured in an oven. The double-layer artificial dura mater has the advantages of simplicity and convenience in operation,clinical practicability, easiness in separation during operation, capability of shortening the operation time and adhesion prevention. The double-layer artificial dura mater is mainly used for conveniently and quickly separating scalp from dura mater and preventing cerebrospinal fluid leakage or postoperative long-term titanium plate exposure when skull repair is carried out on a patient with skull deficiency for the second time.

A non-injury neurosurgery dura mater crochet needle comprises a needle body, the needle body is of a crescent structure, the head of the needle body is sharp, and the tail end of the needle body is connected with a pulling and holding part. A limiting part is arranged on the inner side of the needle body, the limiting part is of a crescent structure which is parallel to the arc of the needle body at intervals, the head of the limiting part is round and blunt, and the tail end of the limiting part is fixedly connected with the needle body; the distance between the head of the limiting part and the head of the needle body is smaller than the thickness of the dura mater, and the distance between the limiting part and the needle body is smaller than the thickness of the dura mater. When the head of the needle body is used for puncturing and lifting the dura mater, on one hand, the head of the limiting part can stop and limit the dura mater to prevent the head of the needle body from puncturing the dura mater to damage brain tissues below, and on the other hand, the distance between the limiting part and the needle body is smaller than the thickness of the dura mater to prevent the dura mater from being damaged. Part of the dura mater after puncture can enter the space between the needle body and the limiting part, the dura mater can be thoroughly prevented from being punctured, and the purpose of protecting the brain tissue below is achieved.

A composite dura substitute implant for implantation at a dura defect site having a porous layer that provides an osteoconductive scaffold for bony ingrowth, a porous layer that provides a scaffold for regeneration of collagen at a dura surface, and an intervening layer for preventing cerebrospinal leakage is disclosed. The composite dura substitute implant facilitates regeneration of dura mater and promotes osteointegration with bony tissue. Methods of manufacturing such an implant and methods of treatment using such composite dura substitute implants are further disclosed.