Method for preparing dura mater with type I collagen and chitosan

A technology of deacetylated chitin and dura mater, which is applied in the field of medical biomaterials, can solve the problems of materials that are hard to attach and easily lead to adhesion

Inactive Publication Date: 2019-05-24
南杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. Fully adhered to the surface of brain tissue and prone to adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1.0 g of commercially available type I collagen and 0.5 g of commercially available chitin, and dissolve them in 100 ml of 0.2 mol / L glacial acetic acid solution. After completely dissolving, the mixture was poured into a mold tray, placed on an automatic shaker, and shaken automatically for 60 minutes, and finally the obtained biofilm was dehydrated to make its water content 40.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 2:1.

Embodiment 2

[0011] Take 10.0 g of commercially available type I collagen and 3.0 g of commercially available chitin, and dissolve them in 100 ml of 0.05 mol / L glacial acetic acid solution. After completely dissolving, pour the mixed liquid into the mold tray, put it on an automatic shaker, shake it automatically for 120 minutes, and finally dehydrate the obtained biofilm to make its water content 10.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 10:3.

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PUM

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Abstract

The invention relates to a method for preparing dura mater with type I collagen and chitosan and belongs to the field of medical biomaterials. The method mainly helps to solve the problem that clinical dura mater repair requires stitching and is prone to causing adhesion. By providing a dura mater receptor with certain porosity and viscosity and a layer of bioactive matrix added anti-adhesion chitosan, the aim of dura mater repair can be achieved. The prepared dura mater is in a three-dimensional structure inherent in type I collagen of different concentrations, as well as type I collagen andchitosan in different spaces, thereby being uniform with certain viscosity and reducing surgical suture operation; by adding a chitosan anti-adhesion layer on the basis of keeping the original activity of the type I collagen, the possibility of postoperative adhesion to cranium can be reduced, high biocompatibility can be achieved, and dura mater repair and reconstruction can be benefited.

Description

technical field [0001] The invention relates to a method for preparing dura mater from type I collagen and deacetylated chitin. It belongs to the field of medical biomaterials. Background technique [0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. It is completely attached to the surface of brain tissue and is prone to adhesion. [0003] In view of this, it is particularly important to develop a biological dura mater that has good biocompatibility; has certain viscosity, does not need to be sutured during surgery, and can prevent adhesions. At present, it is recognized that collagen is a matrix component in multiple tissues, which is beneficial to the growth of variou...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/56C08J5/18C08L89/00C08L5/08
Inventor 南杰
Owner 南杰
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