Novel biofilm material

A biological, I-type technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of materials that are difficult to attach and easily lead to adhesion

Inactive Publication Date: 2019-04-30
关茜茹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. Fully adhered to the surface of brain tissue and prone to adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1.0 g of commercially available type I collagen and 0.5 g of commercially available chitin, and dissolve them in 100 ml of 0.2 mol / L glacial acetic acid solution. After completely dissolving, the mixture was poured into a mold tray, placed on an automatic shaker, and shaken automatically for 60 minutes, and finally the obtained biofilm was dehydrated to make its water content 40.0%. Sterilized by irradiation after sealing the packaging. The mass ratio of type I collagen: chitosan is 2:1.

Embodiment 2

[0011] Take 10.0 g of commercially available type I collagen and 3.0 g of commercially available chitin, and dissolve them in 100 ml of 0.05 mol / L glacial acetic acid solution. After completely dissolving, pour the mixed liquid into the mold tray, put it on an automatic shaker, shake it automatically for 120 minutes, and finally dehydrate the obtained biofilm to make its water content 10.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 10:3.

Embodiment 3

[0013] Take 2.0 g of commercially available type I collagen and 0.5 g of commercially available chitin, and dissolve them in 100 ml of 0.01 mol / L glacial acetic acid solution. After completely dissolving, pour the mixed liquid into the mold tray, put it on an automatic shaker, and shake it automatically for 30 minutes, and finally dehydrate the obtained biofilm to make its water content 1.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 4:1.

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PUM

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Abstract

The invention provides a novel biofilm material, belongs to the field of medical biomaterials, and mainly solves the problems of suture needing and easy adhesion in dural repair currently in clinic. The purpose of dural repair is achieved by providing a bioactive matrix with a certain pore size and stickiness and with addition of anti-adhesion deacetylated chitin on a product layer for a dural receptor. The material prepared by the method has inherent three-dimensional structure in different concentrations of type I collagen and different spaces of type I collagen and deacetylated chitin, is uniform, has a certain stickiness, reduces the operation of surgical suture, increases the anti-adhesion layer of deacetylated chitin on the basis of maintaining the original activity of type I collagen, reduces the probability of adhesion with cranium after operation, has good biocompatibility and is conducive to dural repair and reconstruction.

Description

technical field [0001] The invention relates to a kind of deacetylated chitin and type I collagen are mixed in a certain proportion to form the structural reconstruction of deacetylated chitin and type I collagen, and then the type I collagen that is not combined with the deacetylated chitin is separated by a physical method to form Biofilm material prepared by multi-chitin with type I collagen layer and type I collagen layer method. It is a light yellow, soft, porous, viscous product with good biocompatibility. A new biofilm material. It belongs to the field of medical biomaterials. Background technique [0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. It is complet...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/24A61L27/50
CPCA61L27/20A61L27/24A61L27/50A61L2430/00C08L5/08
Inventor 关茜茹
Owner 关茜茹
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