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Multilayer anti-infection high-strength artificial dura mater and preparation method thereof

An artificial dura mater, high-strength technology, applied in the fields of medical science, non-woven fabrics, filament/thread forming, etc., can solve the problems of unmentioned anti-infective properties of artificial dura mater, limited anti-infective activity, insufficient bonding strength, etc. , to achieve reliable anti-infective properties, protect brain tissue, and improve the effect of binding force

Active Publication Date: 2018-02-02
李瑞锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the artificial dura mater can realize the regeneration of the dura mater and the prevention of scars and adhesions, it has the following disadvantages: (1) the outer fiber is made of polylactic acid / glycolic acid copolymer and chitosan, and when the shell When the polysaccharide content is low, the anti-infective activity will inevitably be limited, and the anti-infective performance of this artificial dura mater is not mentioned in the patent; (2) the outer layer and inner layer fibers need to be placed separately during clinical use At the position of meningeal defect, it is necessary to apply adhesive between the two layers, which greatly increases the inconvenience in clinical use
However, the two layers of this product are prepared by the drum orientation spinning process, and the two layers of the meninges are both oriented nanofibers. The strength of this fiber film is much lower than that of the non-oriented fiber film.
At the same time, the artificial dura mater has only two layers, and the bonding strength between the two layers is not enough

Method used

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  • Multilayer anti-infection high-strength artificial dura mater and preparation method thereof
  • Multilayer anti-infection high-strength artificial dura mater and preparation method thereof
  • Multilayer anti-infection high-strength artificial dura mater and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Preparation of the inner layer: the inner layer material is polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), dissolved in hexafluoroisopropanol (Suzhou Haofan Biological Co., Ltd.), and the concentration of the spinning solution is 5% (wt), stirred for 1 hour, electrospinning parameters were flow rate 1.0ml / h, voltage 12kV, receiving distance 15cm, electrospinning 2h.

[0052] (2) Preparation of the middle layer.

[0053] Films prepared by electrospinning carboxymethyl chitosan (Nantong Lvshen Bioengineering Co., Ltd.) with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0054] Films prepared by electrospinning polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0055] Two kinds of thin strips of 3mm x 1000mm face down, the hydrophilic thin strips are arranged horizontally, an...

Embodiment 2

[0062] (1) Preparation of the inner layer: the inner layer material is polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), which is dissolved in hexafluoroisopropanol (Suzhou Haofan Biological Co., Ltd.), and the concentration of the spinning solution is 7%wt, stirred for 4 hours, electrospinning parameters were flow rate 0.9 ml / h, voltage 13kV, receiving distance 20cm, electrospinning 4h.

[0063] (2) Preparation of the middle layer.

[0064] Films prepared by electrospinning carboxymethyl chitosan (Nantong Lvshen Bioengineering Co., Ltd.) with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0065] Films prepared by electrospinning polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0066] Two kinds of thin strips of 3mm x 1000mm face down, the hydrophilic thin strips are arranged horizont...

Embodiment 3

[0073] (1) Preparation of the inner layer: the inner layer material is polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), which is dissolved in hexafluoroisopropanol (Suzhou Haofan Biological Co., Ltd.), and the concentration of the spinning solution is 5% wt, stirred for 4 hours, electrospinning parameters were flow rate 1.0ml / h, voltage 15kV, receiving distance 25cm, electrospinning 5h.

[0074] (2) Preparation of the middle layer.

[0075] Films prepared by electrospinning carboxymethyl chitosan (Nantong Lvshen Bioengineering Co., Ltd.) with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0076] Films prepared by electrospinning polycaprolactone (Shenzhen Boli Biomaterials Co., Ltd.), with a film thickness of 40 μm. The film was made into thin strips with a width of 3 mm and a length of 1000 mm.

[0077] Two kinds of thin strips of 3mm x 1000mm face down, the hydrophilic thin strips are arranged horizont...

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Abstract

The invention provides a multilayer anti-infection high-strength artificial dura mater, which comprises three layers including a hydrophobic inner layer facing to the cerebrum, a water-soluble chitosan outer layer backing to the cerebrum and a woven type middle layer. The invention also provides a preparation method of the multilayer anti-infection high-strength artificial dura mater. The preparation method comprises the following steps of preparing the hydrophobic inner layer through electrospinning; preparing water-soluble chitosan fine strips; preparing hydrophobic fine strips; preparing the woven type middle layer; preparing the outer layer on the middle layer by an oriented electrospinning process; finally obtaining the artificial dura mater. The artificial dura mater effectively solves the problem of infection in the dura mater repair process; meanwhile, the strength of the traditional artificial dura mater is improved; free cutting can be performed according to requirements; safety and reliability are realized; the application prospects are wide.

Description

technical field [0001] The invention relates to a multilayer anti-infection high-strength artificial dura mater and a preparation method thereof, belonging to the technical field of electrospinning. Background technique [0002] Dural defects are common in neurosurgery clinical work. Open craniocerebral injuries (industry, traffic, war, etc.), tumor erosion, congenital meningeal defects and other craniocerebral diseases can cause dural defects. The dural defect needs to be repaired in time to prevent cerebrospinal fluid from overflowing, to prevent the swelling of the brain and the compression of atmospheric pressure, otherwise it will endanger human life. Dural defects can also cause complications such as intracranial infection, brain adhesions, and subcutaneous fluid, often causing diseases such as headaches and brain dysfunction. [0003] At present, the artificial dura mater made of various materials is being clinically used, which can be divided into two categories: bi...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/50A61L27/58D04H1/728D01D5/00
CPCA61L27/18A61L27/20A61L27/50A61L27/58A61L2430/32D01D5/003D01D5/0069D01D5/0076D01D5/0092D04H1/728C08L67/04C08L5/08
Inventor 李瑞锋王斐李典
Owner 李瑞锋
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