Double-layer artificial dura mater and manufacturing method thereof

Abstract

The invention discloses a double-layer artificial dura mater and a manufacturing method thereof and belongs to the technical field of medical product manufacturing. The double-layer artificial dura mater is composed of two layers of pig-derived pericardium and polydimethylsiloxane bonded with the two layers of pig-derived pericardium. The preparation method of the double-layer artificial dura mater comprises the following steps that a polydimethylsiloxane solution A and a polydimethylsiloxane solution B are mixed, bubbles are removed, the mixture is arranged between two layers of pig-derived pericardium in a coating mode, after bonding, and the pig-derived pericardium is cured in an oven. The double-layer artificial dura mater has the advantages of simplicity and convenience in operation,clinical practicability, easiness in separation during operation, capability of shortening the operation time and adhesion prevention. The double-layer artificial dura mater is mainly used for conveniently and quickly separating scalp from dura mater and preventing cerebrospinal fluid leakage or postoperative long-term titanium plate exposure when skull repair is carried out on a patient with skull deficiency for the second time.

Description

technical field [0001] The invention belongs to the technical field of medical product manufacturing, in particular to a novel neurosurgery material. Background technique [0002] Cranial defect is a common sequelae after injury and postoperative of patients with craniocerebral injury. Because the brain tissue loses the barrier function of the normal skull, it is easy to be injured, and the defect of the skull can cause various symptoms and affect the appearance. Cranioplastic surgery is often required. The large area of ​​skull defect was mainly due to the sharp increase of intracranial pressure caused by closed craniocerebral trauma, cerebral hemorrhage, cerebral contusion, hypertensive cerebral hemorrhage, and large area of ​​cerebral infarction. patient life. [0003] Due to the skull defect after surgery, the dura mater was opened. In order to avoid direct contact between the brain tissue and the scalp, an artificial dura mater was placed between the two. In 1999, the...

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Problems solved by technology

Due to individual differences in patients, the postoperative decompression window is sometimes higher than the bone edge and sometimes lower than the bone edge, which increases the difficulty of the operation and is more likely to cause cerebrospinal fluid leakage, thereby affecting the surgical effect

[0005] The above is the traditional method of skull defect repair, the operation time is longer, the bleeding is more, and the surgical separation of the flap is likely to cause cerebrospinal fluid leakage or local flap thinning, which affects the recovery of the patient's neurological function after surgery. In severe cases, it may lead to exposure of repair materials and infection. etc., making the operation fail, and the operation process is more cumbersome

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