Polyethylene glycol based hydrogel and preparation method and application thereof

A polyethylene glycol-based, polyethylene glycol-based technology, applied in the field of medical materials, can solve problems such as difficult repairs, non-healing incisions, and cerebrospinal fluid leakage, and achieve the prevention of cerebrospinal fluid leakage, no rejection, and good tissue compatibility Effect

Inactive Publication Date: 2020-02-21
重庆思吉瑞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the dura mater defect that may cause cerebrospinal fluid leakage cannot be achieved immediately, fatal complications such as cerebrospinal fluid leakage, incision non-healing, and infection may occur after surgery
In addition, for the base of

Method used

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  • Polyethylene glycol based hydrogel and preparation method and application thereof
  • Polyethylene glycol based hydrogel and preparation method and application thereof
  • Polyethylene glycol based hydrogel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Weigh 200 mg of 4-arm-PEG-NHS with a molecular weight of 10 kDa (molecular structure as shown in formula (I-1), n ​​is equal to 52, R 1 is an ester bond, R 2 succinimide ester), 190 mg of 4-arm-PEG-NH with a molecular weight of 10 kDa 2 (molecular structure as shown in formula (II-1), m is equal to 56, R 3 ether bond), dopamine 1.2mg, in which 4-arm-PEG-NHS was dissolved in 1ml deionized water, 4-arm-PEG-NH 2 Mix with dopamine and dissolve in 1ml of deionized water.

[0058] (2) 4-arm-PEG-NHS solution is A liquid, 4-arm-PEG-NH 2 The mixed solution with dopamine is liquid B.

[0059] (3) Extrude equal volumes of liquid A and liquid B into tubes A and B of a double mixing syringe on a flat surface for about 5 seconds to obtain a colorless transparent hydrogel.

[0060] The hydrogel prepared in Example 1 adheres to the plastic plate, see figure 1 . The hydrogel prepared in Example 1 is attached to the plastic plate, see later figure 2 , it can be seen that th...

Embodiment 8

[0108] (1) Weigh 200 mg of 4-arm-PEG-NHS with a molecular weight of 10 kDa (as shown in formula (I-1), n ​​is equal to 52, R 1 is an ester bond, R 2 succinimide ester), 190 mg of 4-arm-PEG-NH with a molecular weight of 10 kDa 2 (As shown in formula (II-1), m is equal to 56, R 3 ether bond), 6-nitro-L dopamine 1.6mg, wherein 4-arm-PEG-NHS was dissolved in 1ml deionized water, 4-arm-PEG-NH 2 Mix with 6-nitro-L-dopamine and dissolve in 1ml of deionized water.

[0109] (2) 4-arm-PEG-NHS solution is A liquid, 4-arm-PEG-NH 2 The mixed solution with 6-nitro-L dopamine is liquid B.

[0110] (3) Extrude equal volumes of liquid A and liquid B into tubes A and B of a double mixing syringe on a flat surface for about 5 seconds to obtain a colorless transparent hydrogel.

Embodiment 9

[0112] (1) Weigh 200 mg of 4-arm-PEG-NHS with a molecular weight of 10 kDa (as shown in formula (I-1), n ​​is equal to 52, R 1 is an ester bond, R 2 succinimide ester), 190 mg of 4-arm-PEG-NH with a molecular weight of 10 kDa 2 (As shown in formula (II-1), m is equal to 56, R 3 ether bond), α-methyl dopamine 1.4mg, in which 4-arm-PEG-NHS was dissolved in 1ml deionized water, 4-arm-PEG-NH 2 Mix with α-methyl dopamine and dissolve in 1ml of deionized water.

[0113] (2) 4-arm-PEG-NHS solution is A liquid, 4-arm-PEG-NH 2 The mixed solution with α-methyl dopamine is liquid B.

[0114] (3) Extrude equal volumes of liquid A and liquid B into tubes A and B of a double mixing syringe on a flat surface for about 5 seconds to obtain a colorless transparent hydrogel.

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Abstract

The invention provides polyethylene glycol based hydrogel. The polyethylene glycol based hydrogel is prepared through a reaction between a polyethylene glycol derivative and a dopamine derivative. Thehydrogel has excellent adhesiveness when used for meninges repair, a wound surface can quickly form gel, the stressed wound surface can be closed separately, the blocking capability is strong, and the hydrogel is quite suitable for clinical meninges repair. The polyethylene glycol based hydrogel is good in compactness and free of permeability, cerebrospinal fluid leakage can be prevented to wellprotect brain tissue, meninges-brain adhesion cannot occur, tissue compatibility is good, a rejection reaction is avoided, and acute or chronic inflammations cannot be caused; and meanwhile, the hydrogel is safe and nontoxic, does not propagate potential known or unknown infections, can degrade at a proper speed in a body and can be replaced by new tissue.

Description

[0001] Cross References to Related Applications [0002] This application claims the priority of Chinese patent application 201810907676.7 filed on August 10, 2018, the disclosure content of which is incorporated herein by reference. technical field [0003] The invention relates to the field of medical materials, in particular to a polyethylene glycol-based hydrogel and its preparation method and application. Background technique [0004] The dura mater is an important structure of the central nervous system. As a natural barrier, its integrity is of great significance for protecting the function of brain tissue and maintaining neurophysiological activities. The hard brain consists of two layers, the outer layer and the inner periosteum of the skull, the inner layer is thicker than the outer layer, and there are abundant blood vessels and nerves between the two layers. The connection between the dura mater and the skull is loose and easy to separate. When the blood vessels...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L71/02C08G65/333A61L24/00A61L24/04A61L26/00A61L31/06A61L31/14
CPCC08J3/075C08G65/33396A61L26/0019A61L26/008A61L24/0031A61L24/046A61L31/145A61L31/06C08J2371/02C08L71/02
Inventor 姜小燕兰均段海军
Owner 重庆思吉瑞科技有限公司
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