Application of apolipoprotein e receptor mimetic peptide 6kapoep in the preparation of drugs for the treatment of secondary brain injury after cerebral hemorrhage

Abstract

The invention discloses the application of apolipoprotein E receptor mimic peptide 6KApoEp in the preparation of drugs for treating secondary brain injury after cerebral hemorrhage, and discloses the protein sequence of apolipoprotein E receptor mimic peptide 6KapoEp, apolipoprotein E receptor The construction method of the protein sequence of the analog peptide 6KapoEp, and the preparation of the application mixture, after the application of 6KApoEp, the expression of CypA can be reduced, and the cerebral edema and blood-brain barrier damage and inflammation after cerebral hemorrhage can be alleviated by inhibiting the activation of the MMP-9 pathway Factor production; reduce brain water content, improve BBB permeability, promote the increase of blood-brain barrier-related proteins such as claudin-5, occludin, ZO-1, regulate cerebral hemorrhage by inhibiting CypA / NF-KB / MMP-9 Post-inflammatory response, reduce brain tissue water content, improve blood-brain barrier permeability, thereby reducing secondary brain damage after cerebral hemorrhage, play a neuroprotective role in cerebral hemorrhage, reduce post-cerebral hemorrhage inflammatory response, improve blood-brain barrier permeability permeability effect.

Description

technical field [0001] The invention relates to the application of an apolipoprotein E receptor mimic peptide 6KApoEp in the preparation of a drug for treating secondary brain injury after cerebral hemorrhage, and belongs to the technical field of cerebral hemorrhage treatment. Background technique [0002] Intracerebral hemorrhage (ICH) is the second common subtype of stroke, accounting for about 10% to 20% of all strokes, with an incidence of 10 to 30 people / 100,000 / year, and a 30-day mortality rate of 40%. Surviving ICH patients have severe neurological deficits, and only 20% of them can take care of themselves 6 months after the onset, and they still have a high risk of rebleeding and secondary stroke, which seriously threaten the life and health of patients. [0003] The pathophysiological mechanism after cerebral hemorrhage includes secondary brain damage in addition to the rapid accumulation of blood leading to the destruction of normal brain tissue anatomy and the me...

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Problems solved by technology

[0011] Although the anti-inflammatory effect of 6KApoEp has been demonstrated in inflammatory models, the inflammatory response induced by LPS and thrombin after intracerebral hemorrhage may be different, and the results of studies at the cellular level and studies at the animal level may also be different ;Whether the modified 6KApoEp can effectively improve the permeability of the BBB after cerebral hemorrhage and effectively protect the secondary damage of spontaneous cerebral hemorrhage requires us to conduct further objective research and provide new treatment strategies and products for the destruction of the BBB after ICH

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