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Soft capsules for treating apoplexy and preparation method thereof

A technology of soft capsules and soft capsule shells, applied in capsule delivery, medical preparations containing active ingredients, metabolic diseases, etc.

Inactive Publication Date: 2010-06-23
HEBEI RUISHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report about the soft capsule preparation based on leech and astragalus extracts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 prescription (1 # )

[0027] Leech 1000g

[0028] Astragalus 1500g

[0029] Beeswax 15g

[0030] Gelatin 40g

[0031] Glycerin 15g

[0032] Ethyl p-hydroxybenzoate 0.5g

[0033] Appropriate amount of water

[0034] A total of 1000 capsules were made

[0035] Preparation:

[0036] Soak 1000g of leeches for 4 hours, mince them, add 10 times the amount of water, cut and boil three times, filter, concentrate the filtrate to a relative density of 1.05-1.08, add 70% ethanol to stir, let stand for 24 hours, filter and shrink to a thick paste, and dry Crush, add medicinal vegetable oil and antioxidant, sterilize, mix to form a liquid paste, and you get it.

[0037] Take 2000g of leeches and crush them, add 4 times the amount of normal saline, stir well, place at 4°C for 12 hours, pour out the supernatant, extract twice in the same way, and combine the extracts. The pH value of the extract was adjusted to about 4.5 with acetic acid, placed at 4°C for 12 ho...

Embodiment 2

[0040] Embodiment 2 prescription (2 # )

[0041] Leech 1000g

[0042] Astragalus 3000g

[0043] Beeswax 15g

[0044] Gelatin 40g

[0045] Glycerin 15g

[0046]Benzoic acid 0.5g

[0047] Appropriate amount of water

[0048] A total of 1000 capsules were made

[0049] Preparation method is with embodiment 1 prescription (1 # ) preparation method.

Embodiment 3

[0050] Embodiment 3 prescription (3 # )

[0051] Leech 1000g

[0052] Astragalus 3000g

[0053] Panax notoginseng 3000g

[0054] Beeswax 15g

[0055] Gelatin 40g

[0056] Glycerin 15g

[0057] Benzoic acid 0.5g

[0058] Appropriate amount of water

[0059] A total of 1000 capsules were made

[0060] Preparation of notoginseng saponins: Take 3000g of notoginseng medicinal material, add 10 times the amount of 70% ethanol to reflux and extract twice for 2 hours after crushing, recycle ethanol, add water for water sedimentation and centrifugation 101 The macroporous resin is desorbed with 65% ethanol, the analysis solution is collected, and the dried paste is vacuum-dried after recovering the ethanol.

[0061] Preparation method is with embodiment 1 prescription (1 # ) preparation method.

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PUM

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Abstract

The invention relates to soft capsules for treating apoplexy and a preparation method thereof. The inside of each soft capsule shell is extracts of sanguisuge and raidx astragali, also can be added with extracts of auxiliary Chinese medicaments, such as sanchi, snakegourd fruit, earthworm, ginseng and the like, and is added with relevant auxiliary materials, i.e. a dispersing agent, a suspending agent, an antioxygen, a preservative and the like. The preparation method for the soft capsules comprises the following steps: heating, stirring and melting glycerin, distilled water and expanded gelatin in a gelatin pot; adding the preservative in the gelatin pot; adding the extracts of sanguisuge and raidx astragali, the extracts of other auxiliary Chinese medicaments and liquid melt of beeswax and seed fat; and stirring the mixture into the uniform semi-solid substance. The soft capsules whose effective components are highly dispersed in the substrate are prepared by a pressing method or a dropping preparation method. The soft capsules comprising the extract of sanguisuge and raidx astragali are used for activating blood, eliminating stasis, promoting blood circulation and relieving pain, are suitable to treat meridian qi deficiency and blood stasis type cerebral infarction symptoms in the apoplexy, coronary heart disease, angina, acute myocardial infarction and ischemic cerebral apoplexy, can obviously reduce arteria vertebralis resistance and improve cerebral ischemia and brain circulation, and also can be used for disseminated intravascular coagulation and absorption of intracerebral hematoma of cerebral hemorrhage convalescence and sequelae. The soft capsules of the invention have physicochemical property, stable drug effect and high bioavailability, and can cover bad taste and odor of the medicament.

Description

technical field [0001] The invention relates to a soft capsule for treating stroke and a preparation method thereof. The soft capsule shell contains extracts of leeches and astragalus, and complementary traditional Chinese medicines such as notoginseng, trichosanthes, earthworm, ginseng, etc. can also be added, as well as related dispersants, suspending agents, antioxidants, preservatives, etc. Accessories. Its preparation method is heating and stirring glycerin, distilled water and expanded gelatin in a glue pot to melt, adding preservatives, adding leeches and astragalus extracts and other complementary traditional Chinese medicine extracts, melting with beeswax and vegetable oil, and stirring to form Mix well into a semi-solid. The soft capsule preparation in which the active ingredient is highly dispersed in the matrix is ​​prepared by a compression method or a dropping method. The soft capsule of leech and astragalus extract of the present invention is used for promoti...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K36/428A61K9/48A61K47/42A61P9/10A61P3/06A61P9/12A61K35/62A61K35/64
Inventor 马宏志刘河赵如胜
Owner HEBEI RUISHENG PHARMA
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