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Medical anti-sticking membrane and preparation method thereof

An anti-adhesion film and anti-adhesion technology, applied in the field of biomedicine, can solve the problems of no medical anti-adhesion film, easy sliding of the isolation film, poor adhesion, etc., and achieve easy control of product quality, low cost and low cost. cost effect

Active Publication Date: 2010-01-13
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] (2) Self-adhesive performance is good, but adhesion is not good. The application of surgical adhesive membrane is greatly restricted, such as between the peritoneum and the intestinal tube, between the intestinal tube and the intestinal tube, because the intestinal tube is in constant peristalsis, the isolation membrane is easy to slide , potentially causing new trauma to previously healthy parts
However, bioprinting technology is still in the stage of basic research, and there has been no direct use of cells to prepare related biological products through bioprinting technology, and there have been no reports on the application of bioprinting technology to the preparation of medical anti-adhesion films.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of anti-adhesion film

[0053] (1) Preparation of electrospinning solution, hydrosol solution containing hemostatic factor and cross-linking agent solution:

[0054] Select hydrophobic L-polylactic acid and ε-caprolactone, the ratio of the two is 50:50, as a copolymerized polymer material, the number average molecular weight is 260,000, and it is prepared by dissolving in 85% hexafluoroisopropanol by mass Electrospinning solution.

[0055] The cross-linking agent solution is 0.1M calcium chloride solution.

[0056] The hydrosol solution containing the hemostatic factor adopts the hemostatic factor alginate solution, and the mass percent concentration of the hemostatic factor in the cytokine alginate solution is 10 ppm.

[0057] Put an appropriate amount of prepared 0.1M calcium chloride solution into a cell culture dish with a diameter of 150mm, and place it on the flat receiver shared by the electrospinning device and the printer. Refit the Hewlett-Packa...

Embodiment 2

[0065] Preparation of anti-adhesion film

[0066] 1. Preparation of electrospinning solution, hydrosol solution containing drugs and hemostatic factors and cross-linking agent solution:

[0067] (1) Select hydrophobic polycaprolactone and dissolve it in a chloroform / methanol mixed solvent to prepare an electrospinning solution. The ratio of chloroform and methanol is 1:1, and the mass ratio of polycaprolactone to solvent is 15:85.

[0068] The cross-linking agent solution is 0.1M calcium chloride solution.

[0069] The hydrosol solution that contains medicine and hemostatic factor adopts hemostatic factor and ceftriaxone sodium alginate solution, the mass percent concentration of hemostatic factor in the described alginate solution is 10ppm, and the cephalosporin in the described ceftriaxone sodium alginate solution The mass percentage concentration of Trixone sodium is 3%.

[0070] Put an appropriate amount of prepared 0.1M calcium chloride solution into a cell culture dish...

Embodiment 3

[0078] Carry out rabbit animal experiment with the anti-adhesion film that embodiment 2 makes:

[0079] Fifteen rabbits were given general anesthesia. The abdomen of the rabbits was cut open along the midline, the uterine horns were taken out, and the serosa at the uterine horns was destroyed to cause bleeding and wounds. Grouped into groups, 5 rats were treated with anti-adhesion film as the experimental group, 5 rats were treated with Chengdu Dikang anti-adhesion film as the positive control group, and 5 rats were used as the blank control group, and then the abdominal wall was sutured. After 14 days, the materials were collected for observation. It was found that there was no adhesion in the abdominal cavity of the rabbits in the experimental group, and the anti-adhesion membrane degraded significantly, with an excellent and good rate of 100%. The two wounds in the positive control group delayed healing, but did not affect the final result, with an excellent and good rate o...

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Abstract

The invention provides a medical anti-sticking membrane and a preparation method thereof. The anti-sticking membrane comprises a nanometer frame and hydrosol attached thereon. The hydrosol is internally packed with one or several kinds of styptic medicament or / and anti-sticking medicament. The invention also provides a preparation method of the anti-sticking membrane, comprising the following steps of: preparing electro-spinning solution, styptic medicament and / or anti-sticking medicament-containing hydrosol solution and crosslinker solution; receiving static spinning with the crosslinker solution to obtain the nanometer frame; printing the styptic medicament and / or anti-sticking medicament-containing hydrosol solution onto the nanometer frame by an ink-jet printer, and solidifying the hydrosol solution to obtain the anti-sticking membrane. The anti-sticking membrane has good capability and biological compatibility, and nontoxicity as well as nonirritant, can be completely degraded and absorbed, is compounded with controllably released styptic medicament or / and anti-sticking medicament, has controllable degrading time and speed, and conquers defects of the prior art.

Description

technical field [0001] The invention relates to a medical anti-adhesion film and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Tissue adhesion after surgery has always been a major problem in clinical medicine. There are nearly 10 million surgical cases of various types in the country every year, and almost all operations involve anti-adhesion between tissues and local anti-inflammation. Tissue adhesions after surgical operations on the human abdomen, cardiovascular, spine, bone joints, legs, and gynecological pelvic cavity not only bring great pain to patients, but also cause huge economic losses. Postoperative adhesions can cause serious complications, such as abdominal and pelvic cavity can cause adhesive ileus, recurrent laryngeal nerve injury after thyroid surgery, heart and thorax adhesions require another thoracotomy and pelvic tissue adhesions The resulting female infertility is also the main reason for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/06A61L31/04A61L31/16
Inventor 徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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