Fat-soluble vitamin freeze-dried prepn. and its prepn. method

A technology for fat-soluble vitamins and freeze-dried preparations, which can be used in freeze-dried transportation, pharmaceutical formulations, organic active ingredients, etc., and can solve problems such as insoluble in water

Inactive Publication Date: 2007-01-31
青岛众智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the above problems, the present invention appropriately adds hydrophilic surfactant polysorbate 80 and mannitol to fat-soluble vitamins, utilizes freeze-drying process, regulates freeze-drying temperature and freeze-drying speed, freeze-drying

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Vitamin A Palmitate 3.3 million units

[0039] Vitamin D 2 200,000 units

[0040] Vitamin E 10,000 units

[0041] Vitamin K 1 0.15g

[0042] Polysorbate 80 50g

[0043] Mannitol 100g

[0044] Water for injection up to 3000ml

[0045] A total of 1000 bottles were made

[0046] The preparation process is as follows:

[0047] Pretreatment: Weigh the mannitol, add appropriate amount of water, heat to dissolve, cool, and set aside. Weigh vitamin A palmitate, vitamin K 1 , vitamin E, vitamin D 2 and polysorbate 80, mix well, add water to dissolve, add to the mannitol solution, check the pH value of the liquid (if necessary, use sodium hydroxide or hydrochloric acid solution to adjust the pH value to 6.5-9.0), add water for injection to the full amount, Add 0.01% (g / ml) activated carbon, stir at room temperature for 30 minutes, filter with a titanium filter stick, filter with a 0.22 μm microporous membrane, and fill. Press halfwa...

Embodiment 2

[0054] Vitamin A Palmitate 2.3 million units

[0055] Vitamin D 2 400,000 units

[0056] Vitamin E 7,000 units

[0057] Vitamin K 1 0.20g

[0058] Polysorbate 80 50g

[0059] Mannitol 100g

[0060] Water for injection up to 3000ml

[0061]A total of 1000 bottles were made

[0062] The preparation method is the same as in Example 1, except that the re-drying time in the freeze-drying process is 9 hours.

Embodiment 3

[0064] Vitamin A Palmitate 4 million units

[0065] Vitamin D 2 300,000 units

[0066] Vitamin E 15 thousand units

[0067] Vitamin K 1 0.15g

[0068] Polysorbate 80 70g

[0069] Mannitol 50g

[0070] Water for injection up to 3000ml

[0071] A total of 1000 bottles were made

[0072] The preparation method is the same as in Example 1, except that the re-drying time in the freeze-drying process is 3 hours. .

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PUM

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Abstract

A freeze-dried liposoluble vitamin with high water solubility and stability and its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of fat-soluble vitamin preparations, and more specifically relates to a freeze-dried preparation of various fat-soluble vitamins. Background technique [0002] Fat-soluble vitamins are essential nutrients for the human body, and critically ill patients urgently need to be supplemented clinically. Fat-soluble vitamins include A, D, E, and K 1 Four, co-exist with lipids in food, are also related to lipid absorption during intestinal absorption, and have low excretion efficiency. [0003] Pharmacological effects of vitamin A: vitamin A can promote growth and maintain normal functions of epithelial tissues such as skin, conjunctiva, cornea, etc., and participate in the synthesis of rhodopsin, enhance retinal photosensitivity; participate in many oxidation processes in the body, especially unsaturated Fatty acid oxidation, but people must not take too much, so as not to cause chronic poisoning. This product is beneficia...

Claims

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Application Information

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IPC IPC(8): A61K31/592A61K9/19A61P3/02A61K31/122A61K31/07A61K31/355
Inventor 吴玉柱宁辉于伟江张慧黄永宁岩李娟
Owner 青岛众智医药科技有限公司
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