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Beta-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and preparation method thereof

A technology for grafting hydroxypropyl chitosan water and derivatives is applied in the field of β-cyclodextrin derivative grafting hydroxypropyl chitosan hydrogel and its preparation, which can solve the problem that the controlled release of hydrophobic drugs is difficult to play. function and other issues, to achieve good biocompatibility and expand the scope of application.

Active Publication Date: 2017-11-24
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel matrix is ​​mainly hydrophilic, and it is mainly used in the field of drug controlled release for hydrophilic drugs, and it is difficult to play a role in the controlled release of hydrophobic drugs.

Method used

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  • Beta-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and preparation method thereof
  • Beta-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and preparation method thereof
  • Beta-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Weigh β-CD and prepare its saturated solution with distilled water at 80-90°C, then cool to room temperature, filter to obtain β-CD crystals, repeat the above operation once for the obtained β-CD crystals, and finally Vacuum drying at -90°C to obtain β-CD crystals with a purity of more than 99.9%;

[0050] (2) Weigh 17.04g (15mmol) of β-CD crystals obtained by recrystallization and 14.70g (150mmol) of maleic anhydride, add them to a 250ml three-necked flask equipped with a thermometer, and add 137ml N,N-dimethyl The three-necked flask was placed in a multi-functional ultrasonic extractor, the set temperature was 70°C, the ultrasonic time was 6h, and it was divided into three stages, the first stage, the ultrasonic frequency was 25KHz, the ultrasonic time was 2h, and the second stage , ultrasonic frequency 35KHz, ultrasonic time 2.5h, the third stage, ultrasonic frequency 45KHz, ultrasonic time 1.5h; take three clean reactors, respectively No. 1, No. 2, No. 3, No. 1 ...

Embodiment 2

[0056] (1) Weigh 17.04g (15mmol) of β-CD crystals obtained by recrystallization and 14.70g (150mmol) of maleic anhydride, add them to a 250ml three-necked flask equipped with a thermometer, and add 170ml N,N-dimethyl The three-necked flask was placed in a multi-functional ultrasonic extractor, the set temperature was 70°C, and the ultrasonic time was 5 hours. It was divided into three stages. In the first stage, the ultrasonic frequency was 25KHz, and the ultrasonic time was 2.5 hours. In the first stage, the ultrasonic frequency is 35KHz, and the ultrasonic time is 1.5h. In the third stage, the ultrasonic frequency is 45KHz, and the ultrasonic time is 1h; three clean reactors are taken, namely No. 1, No. 2, and No. 3, and 50ml Dichloromethane, the three-necked flask is connected to the No. 1 reactor with a two-way peristaltic pump and peristaltic pump tube to form a circulation system. After the first stage of the ultrasonic process, the liquid in the three-necked flask is pum...

Embodiment 3

[0059] (1) Weigh 8.52g (7.5mmol) of β-CD crystals obtained by recrystallization and 7.35g (75mmol) of maleic anhydride, add them to a 250ml three-necked flask equipped with a thermometer, and add 43ml of N,N-2 Methyl formamide, the three-necked flask was placed in a multi-functional ultrasonic extractor, the set temperature was 60°C, the ultrasonic time was 6h, divided into three stages, the first stage, ultrasonic frequency 25KHz, ultrasonic time 2h, the second stage, ultrasonic frequency 35KHz, ultrasonic time 3h, third stage, ultrasonic frequency 45KHz, ultrasonic time 1h; take three clean reactors, namely No. 1, No. 2, No. 3, No. 1 reactor is equipped with 17ml three Chloromethane, the three-necked flask is connected to the No. 1 reactor with a two-way peristaltic pump and peristaltic pump tube to form a circulation system. After the first stage of the ultrasonic process is completed, the liquid in the three-necked flask is pumped into the No. 1 reactor, and the No. 1 react...

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Abstract

The invention provides beta-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and a preparation method thereof. The invention provides novel maleic anhydride modified beta-cyclodextrin grafted hydroxypropyl chitosan hydrogel and a preparation method thereof. Firstly, beta-cyclodextrin and maleic anhydride are used as raw materials; a multifunctional ultrasonic extractor is used for preparing the maleic anhydride modified beta-cyclodextrin; then, the maleic anhydride modified beta-cyclodextrin is used for reacting with hydroxypropyl chitosan through carboxyls and aminos; amido bonds are generated. The preparation method has the advantages that the cost is lower; the yield is high; the reaction conditions can be easily controlled. The prepared hydrogel is uniform and stable and has good biocompatibility.

Description

【Technical field】 [0001] The invention relates to a preparation method of a hydrogel, in particular to a β-cyclodextrin derivative grafted hydroxypropyl chitosan hydrogel and a preparation method thereof. 【Background technique】 [0002] Hydrogel is a kind of hydrophilic polymer with network cross-linked structure. As a functional polymer material, it has shown good application prospects in the field of drug delivery systems. Through chemical cross-linking or physical force, the hydrogel makes the hydrophilic polymer chain form a network structure, wraps the drug in the network, and through the force between the drug and the cross-linked network, or the cross-linked network itself under certain conditions Under the contraction relaxation, to achieve the purpose of controlled release of drugs. However, the hydrogel matrix is ​​mainly hydrophilic, and it is mainly used in the field of drug controlled release for hydrophilic drugs, and it is difficult to play a role in the cont...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08G81/00C08B37/16C08L87/00
CPCC08B37/0003C08B37/0012C08G81/00C08J3/075C08J2387/00
Inventor 秦大伟韩艳红
Owner QILU UNIV OF TECH
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