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Water-dispersible cannabidiol product and preparation method thereof

A cannabidiol and dispersibility technology, which is applied to the field of water-dispersible cannabidiol products and their preparation, can solve the problems of insoluble cannabidiol in water and low cannabidiol efficiency, and achieves improved bioavailability, increased Stability, effect of solution clarification

Inactive Publication Date: 2020-01-17
GUILIN NATURAL INGREDIENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since cannabidiol is extremely insoluble in water, and the body's absorption of cannabidiol is not efficient, this has become a major obstacle to its physiological function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of the organic phase of cannabidiol: take 0.1 kg of purified cannabidiol crystals with a mass content of cannabidiol of 99%, and use n-hexane as a solvent to prepare 1 L of cannabidiol solution, which is called the organic phase;

[0020] Water phase: Take 1 kilogram of sodium starch octenyl succinate (product model HI-CAP100) as an emulsifier to make an aqueous solution of the emulsifier, called the water phase;

[0021] Mixing of organic phase and water phase: under low speed stirring (100r / min), slowly pour the organic phase into 20L of water phase, and continue stirring at high speed (800r / min) for 10min to make the mixture even.

[0022] High-speed shear emulsification: the obtained mixed solution was emulsified for 2 min at a rotational speed of 8000 r / min to obtain a coarse emulsion.

[0023] Ultra-high pressure homogenization treatment: Homogenize the coarse emulsion for 15 minutes under a pressure of 100MPa, so that the particle diameter of cannabid...

Embodiment 2

[0028] Preparation of the organic phase of cannabidiol: take the cannabidiol oleoresin with a mass content of cannabidiol of 40% and use ethyl acetate as a solvent to prepare a cannabidiol solution, which is called the organic phase, in kg / L, the cannabidiol The mass ratio of diphenol to organic phase is 3:100.

[0029] Water phase: choose starch sodium octenyl succinate and maltodextrin as emulsifier to make an aqueous solution of emulsifier, called water phase, in kg / L, the mass volume ratio of emulsifier to organic phase is 2: 100.

[0030] Mixing of the organic phase and the water phase: under low speed stirring (100r / min), slowly pour the organic phase into the water phase, the volume ratio of the organic phase and the water phase is controlled at 1:10, and continue to stir at a high speed (800r / min) 10min to make the mixture uniform.

[0031] High-speed shear emulsification: the obtained mixed solution was emulsified for 10 min at a rotational speed of 10000 r / min to o...

Embodiment 3

[0037] Preparation of cannabidiol organic phase: take cannabidiol oleoresin with a mass content of cannabidiol of 1%, and use n-heptane petroleum ether as a solvent to prepare cannabidiol solution, which is called organic phase, in kg / L, The mass volume ratio of the cannabidiol to the organic phase is 8:100.

[0038] Water phase: choose maltodextrin, cornstarch, and algae polysaccharides as emulsifiers to make an aqueous solution of emulsifier, called water phase, in kg / L, the mass volume ratio of emulsifier to water phase It is 1:100.

[0039] Mixing of the organic phase and the water phase: under low speed stirring (100r / min), slowly pour the organic phase into the water phase, the volume ratio of the organic phase and the water phase is controlled at 1:20, and continue to stir at a high speed (800r / min) 10min to make the mixture uniform.

[0040] High-speed shear emulsification: the obtained mixed solution was emulsified for 30 min at a rotational speed of 15000 r / min to ...

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Abstract

The present invention relates to the field of food processing and particularly relates to a water-dispersible cannabidiol product and a preparation method thereof. The water-dispersible cannabidiol product comprises an obtained product prepared by the following method: adding an organic phase containing cannabidiol into a water phase for emulsification, adding glycosylase for a glycosylation treatment after removing organic solvent in an emulsion, and conducting drying to prepare the water-dispersible cannabidiol product. The prepared water-dispersible cannabidiol product can be quickly dispersed and dissolved in an aqueous solution, the solution is clear, and no precipitate is produced after long-term placing. The product after the glycosylation treatment is a glucoside mixture with the cannabidiol as a parent nucleus structure and introducing different sugar chain structures to phenolic hydroxyl groups. The product solves a problem that the cannabidiol is insoluble in water and can be widely applied to the food and beverage industry.

Description

technical field [0001] The invention relates to the field of food processing, in particular to a water-dispersible cannabidiol product and a preparation method thereof. Background technique [0002] The antioxidant cannabidiol (CBD) extracted from cannabis (Cannabis sativa Linn.) is a non-addictive active ingredient with no neurotoxicity, which can antagonize the psychoactive activity induced by THC agonizing cannabinoid type I receptor (CB1R). In addition, the pharmacology of cannabidiol (CBD) has been confirmed to have anti-convulsant, anti-vomiting, anti-spasm, anti-anxiety, sedative, anti-insomnia, anti-inflammatory, anti-oxidant and anti-stable effects. pharmacological activity. Cannabidiol (CBD) can be used in many fields such as pharmaceuticals, health products, and food. [0003] Since cannabidiol is extremely difficult to dissolve in water, and the efficiency of the human body to absorb cannabidiol is not high, this has become a major obstacle to exerting its phys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L2/52
CPCA23L33/105A23L2/52A23V2002/00A23V2300/46A23V2300/26A61K31/05A61K9/1652A61K9/0095A61K9/1664A61K9/1075A61K47/36A61K47/46
Inventor 宋云飞秦本军谢永富
Owner GUILIN NATURAL INGREDIENTS CORP
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