The invention provides a medicine composition containing an m-diamide compound and application of the medicine composition. The medicine composition comprises an effective component A and an effectivecomponent B, wherein the effective component A is an m-diamide compound of a structure of a formula I shown in the description; and the effective component B comprises any one or a combination of twoof other insecticides. The composition with the effective component A and the effective component B, which is provided by the invention, has unique functions of synergism, resistant insect control, activity spectrum expansion, virus transmission insect control, and the like, and is capable of effectively preventing and treating a diversity of diseases and insects of crops such as rice, corn, wheat, vegetables, fruit trees, flowers, oil plants and sugar plants, and gardening and forestry as well.