Real-time quantification of skin burns in external beam radiation therapy
A radiation therapy, skin technology, applied in the field of medical equipment, can solve skin burns and other problems
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[0012] In accordance with the present principles, systems and methods are provided for preventing and / or alleviating skin burns in patients as a result of external beam radiation therapy (EBRT). The present principles can be used in adaptive radiation therapy (RT) planning and delivery protocols, which can use minimization of skin reactions as an additional optimization parameter in the design of adaptive treatment planning. In some embodiments, optical or photoacoustic imaging techniques are used to quantitatively image radiation-induced skin burns in real-time during EBRT delivery, and at various intervals after EBRT delivery.
[0013] In addition to altering the local perfusion pattern with increased vasodilation, skin burns are known to alter the levels of hemoglobin and water content in the affected area. Diffuse optical tomography (DOT) imaging measures tissue concentrations of hemoglobin, water, and oxygen saturation. A suitable imaging protocol is described in conjunc...
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