31 results about "Beta-Hydroxybutyric acid" patented technology

The invention discloses a postpartum new dairy cow drenching nutritious supplementary and application thereof in a nutritious supplementary for treating postpartum hypocalcemia, abomasum displacement or ketosis disease of dairy cow. The nutritious supplementary provided by the invention is capable of effectively maintaining the levels of blood calcium, blood magnesium and glucose and reducing the levels of NEFA (Non-Esterified Fatty Acid) and beta-hydroxybutyric acid, thereby effectively reducing the occurrence rate of metabolic diseases of postpartum paralysis, ketosis, abomasum displacement and the like of new dairy cow. As a result, the dairy cow can be rehabilitated in physical power and food intake quickly, and the health condition of the dairy cow can be improved and the milk yield of the dairy cow can be increased; and good economic benefit can be achieved.

The invention provides a kit for detecting urinary lactic acid, creatine and beta-hydroxybutyric acid of human urine simultaneously, comprising a urine purification unit and a dry chemical reaction unit, wherein the urine purification unit is provided with a selective absorbent with combination of neutral alumina and activated carbon in weight ratio of 0.2-1:0.1-2, wherein the activated carbon is soaked by sodium hydroxide with concentration of 10-20%, and the selective absorbent is baked in a closed in a drying oven at the temperature of 70-250 DEG C for 4-72h; and the dry chemical reaction unit is a reaction box with a urinary lactic acid detection hole, a creatine detection hole and a beta-hydroxybutyric acid detection hole. The invention can detect concentration of urinary lactic acid, creatine and beta-hydroxybutyric acid of human urine simultaneously quickly and easily without help of other instruments and professional personnel so as to obtain qualitative or semiquantitative results.

The invention relates to stabilized beta-hydroxybutyric acid detection test paper and a preparation process thereof. The stabilized beta-hydroxybutyric acid detection test paper consists of a whole blood filter layer, a developing layer and a base layer which are sequentially stacked, wherein the whole blood filter layer is formed by combining at least one polymer film layer; the developing layer is made of a hydrophilic material; and the base layer is made of an insoluble supportive material. The method for preparing the stabilized beta-hydroxybutyric acid detection test paper comprises the following steps of: a, soaking the developing layer into reagent solution for 2 hours, taking the soaked developing layer out, and drying the soaked developing layer by cold air; and b, cutting the whole blood filter layer, the soaked and dried developing layer and the base layer into the same specifications, and sequentially bonding the layers with glue from top to bottom. The test paper is not limited by conditions such as region and the like; patients can conveniently perform self-monitor at any time and at any place; the concentration of beta-hydroxybutyric acid can be detected in a short time by only using micro blood; and the test paper is simple to prepare and has wide market value.

The invention belongs to the technical field of powdery paint, and particularly relates to self-catalysis fast curing type pure polyester resin, and further discloses a preparation method of the elf-catalysis fast curing type pure polyester resin and a purpose of the elf-catalysis fast curing type pure polyester resin for preparing outdoor TGIC powder paint. The self-catalysis fast curing type pure polyester resin is prepared by using terephthalic acid, 1,4-naphthalic acid, trimethyl-1,6-hexanediol, neopentyl glycol, 1,2,4-butanediol, gamma-trimethylamine-beta-hydroxybutyric acid, N,N,N-trimethyl-2-hydroxyhexadecyl ammonium chloride and glycol bis(2-aminoethyl ether) tetraacethyl as raw materials through polymerization. The self-catalysis performance of the polyester resin is prominent; the curing activity is high; under the condition without additionally adding a curing accelerant, the fast curing with a curing agent TGIC can be realized. A curing membrane prepared by the self-catalysis fast curing type pure polyester resin has excellent performance; the performance in all aspects better reaches the use requirements of outdoor pure polyester resin.

The invention provides a composition containing L-carnitine and a beta-hydroxybutyric acid compound, and specifically provides a composition containing the L-carnitine and at least one beta-hydroxybutyric acid compound. The beta-hydroxybutyric acid compound comprises beta-hydroxybutyrate, a beta-hydroxybutyric acid precursor or a combination thereof; and preferably, the L-carnitine and beta-hydroxybutyric acid amino acid exist in the composition in a form of intramolecular salt. The invention furthermore provides a preparation method of the L-carnitine-beta-hydroxybutyrate. The composition provided by the invention is high in stability, high in bioavailability and significant in weight loss effect and ketogenic effect; and the preparation method provided by the invention is easy and convenient to operate.

The invention discloses a biodegradable peanut protein plastic with a long service life. The biodegradable peanut protein plastic comprises the following raw material in parts by weight: 30 to 35 parts of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV, 55 to 60 parts of modified-beta-hydroxybutyric acid, 15 to 20 parts of peanut protein powder, 15 to 18 parts of nano cellulose whiskers, 3 t o 5 parts of amylase, 1.1 to 1.3 parts of a silane coupling agent KH590, 2 to 3 parts of sodium lactate, 0.5 to 0.8 parts of sodium dehydroacetate, 1.7 t o 2.3 parts of dioctyl terephthalate DOTP, 2 to 4 parts of octyl epoxy stearate, 25 to 28 parts of carbon black N550, 12 to 16 parts of ground calcium carbonate, 4 to 7 parts of kaolin, 10 to 12 parts of hard pottery clay, and 0.7 to 0.9 parts of an antioxidant. The peanut protein plastic can be biologically degraded into low molecular compound, is high in flexility, good in impact resistance and oxidation resistance, low in water absorption, and low in complete degradation velocity, and the service life of the biodegradable peanut protein plastic can be prolonged.

The invention discloses a marker group for diagnosing and distinguishing coronary arterial atherosclerosis from stable angina pectoris. The marker group comprises one or more of glutathione, beta-hydroxybutyric acid, proline, fumaric acid, phenylalanine and lactic acid. When a single marker is used for diagnosing and distinguishing patients with the stable angina pectoris from patients with the coronary arterial atherosclerosis, the AUCs (areas under curve) of a ROC (receiver operating characteristic) are all 0.7 or larger, and the marker has a clinical diagnosis significance; when the markers are used for diagnosis in combination, with the increase of the combination number, the AUC is further increased and reaches 0.988 when 6 markers are combined, and the sensitivity and the specificity are 98.5% and 98.3% respectively under the optimum cutoff value. The metabolic marker group can accurately diagnose and distinguish the coronary arterial atherosclerosis from the stable angina pectoris, and is high in sensitivity and specificity.

The invention discloses a method for preparing a test paper for rapidly determining dairy cows subclinical ketosis, which comprises the following steps of: adding boric acid, aminoacetic acid and ethylene diamine tetraacetic acid solution in Arabic gum dissolved in a hot-water bath, adjusting the pH value of the prepared solution to be 7.0, soaking the test paper for 20 minutes in the prepared solution while the prepared solution is hot, drying the test paper in a drying oven at 60 DEG C, and standing the test paper in the drying oven overnight; and dissolving ethylene glycol, sodium nitroprusside and absolute ethyl alcohol in the hot-water bath, soaking the test paper for 20 minutes in the prepared solution while the prepared solution is hot, taking the test paper out, blotting moisture in the test paper by using filter paper, drying the test paper in the drying oven at 60 DEG C, and standing the test paper in the drying oven overnight so as to obtain the test paper. The reagent strip takes the concentration of beta-hydroxybutyric acid in blood more than 1.2mmol/L as a positive criteria; and the production practice proves that the reagent strip has the advantages of low cost, simple and easy operation, quick response, high specificity and high sensitivity, can be used for various determined samples such as blood, urine, serum, plasma and milk, and has wide application scope.

The invention discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof, particularly discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing and treating diabetes mellitus and chronic complication thereof, and belongs to the technical field of medicines. A diabetes rat model is induced with streptozotocin (STZ); the prevention and treatment effects of the beta-hydroxybutyric acid on diabetes and chronic complication of rats are observed with the beta-hydroxybutyric acid through subcutaneous injection; the result shows that the weight loss of the rats can be restrained by the beta-hydroxybutyric acid; the pathology function change of chronic pancreas, great vessels, kidneys, hearts, livers and the like of the rats is improved; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof as an active pharmaceutical ingredient is combined with conventional additives in the field of medicines to prepare medicines; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof can be used for improving the diabetes and the chronic complication thereof; and clinical treatment is carried out by aiming at diseases caused by anti-oxidative stress and nitration injuries.

The invention discloses health-care granules for preventing the negative balance of energy metabolism of cows and a using method of the health-care granules. The health-care granules disclosed by the invention are mainly prepared from the following raw materials: calcium propionate, brown sugar, magnesium chloride, yeast, sodium chloride and corn flour. The health-care granules for feeding the cows, disclosed by the invention, have the advantages of being convenient to use, low in cost, good in palatability, notable in effects and the like. After the postnatal cows are fed with the health-care granules, physical strength can be quickly restored, the quantity of rumen microbial populations can be maintained, the food consumption is restored, the milk yield is increased, and the ability of resisting diseases is improved. Feeding experiments for the postnatal cows confirm that the health-care granules can effectively maintain the level of blood calcium (Ga), serum phosphate (P), blood magnesium (Mg) and blood sugar (GLU), and can reduce the level of beta-hydroxybutyric acid (BHBA), free fatty acid (NEFA), and aspartate aminotransferase (AST). The attack rate of nutrient metabolic disease-ketosis of the postnatal cows can be effectively reduced.

The invention provides an ultraviolet-proof and biodegradable packaging film. The packaging film comprises a biodegradable ultraviolet reflecting layer and a photodegradable ultraviolet absorbing layer, wherein the biodegradable ultraviolet reflecting layer is prepared from a poly(beta-hydroxybutyric acid)-beta-hydroxypentanoic acid copolymer, aluminum powder, lubricant paraffin, a calcium-zinc compound stabilizer and maleic anhydride, and the photodegradable ultraviolet absorbing layer is prepared from an ethylene-carbon monoxide copolymer, an anti-ultraviolet mixture, titanium dioxide and the lubricant paraffin, wherein the thickness ratio of the biodegradable ultraviolet reflecting layer to the photodegradable ultraviolet absorbing layer is 1:(1-3), and the thickness of the photodegradable ultraviolet absorbing layer ranges from 0.005mm-0.12mm. The ultraviolet-proof and biodegradable packaging film is capable of rejecting more than 90% of ultraviolet, has excellent mechanical and physical properties, and can be degraded 100% without any pollution on the environment.

The invention discloses application of betulinic acid in promotion of fatty-acid oxidation and particularly relates to the application of betulinic acid in preparation of medicines for preventing or treating related diseases of fatty-acid oxidation. The application disclosed by the invention has the beneficial effects that a fat C57 mouse with high-fat feeding for modeling is adopted as a researchobject, and the experimental result shows that the gene levels of the high-fat mouse treated by betulinic acid and the fatty-acid oxidation are respectively and obviously increased in different tissues, and the content of beta-hydroxybutyric acid (beta-OHB) in serum is also increased, i.e., betulinic acid can promote fatty-acid oxidation. Meanwhile, the body weight of the high-fat mouse treated by betulinic acid is obviously reduced; the application provides actual evidence of betulinic acid for treating obesity, non-alcoholic fatty liver disease (NAFLD) and other diseases related to the fatty-acid oxidation, has important scientific value and medical significance, and meanwhile can provide precious experiences for developing more natural-medicine active components for treating related diseases by promoting the fatty-acid oxidation.

The invention discloses an environmentally friendly antibacterial plastic film, which comprises a film matrix and an antibacterial layer covered on the surface of one side of the film matrix. The filmmatrix is prepared from following raw materials in parts by weight: 60 to 70 parts of polyethylene, 20 to 30 parts of poly(beta-hydroxybutyric acid), 3 to 4 parts of modified bamboo powder, 5 to 8 parts of polyethylene wax, 2 to 3 parts of iron stearate, 1 to 2 parts of an antioxidant, and 1 to 2 parts of a plasticizer. The antibacterial layer is formed by painting an antibacterial liquid on thesurface of the film matrix. The invention further discloses a preparation technology of the plastic film. Polyethylene and poly(beta-hydroxybutyric acid) are taken as the film matrix; under the actionof iron stearate, poly(beta-hydroxybutyric acid) can effectively exert the biodegradation performance and a photo degradation performance; then modified bamboo powder is added to enhance the mechanical properties and strength; the antibacterial liquid is painted on the surface of the film matrix to form the antibacterial layer, which has an excellent antibacterial performance, at the same time, the binding force between the antibacterial layer and the film matrix is also enhanced; and the integrity of the plastic film is improved.

The invention discloses environmentally-friendly degradable packaging paper, the raw materials of which include, by weight, 100-120 parts of kraft paper, 40-60 parts of polylactic acid, 4-8 parts of modified microspheres, 2-8 parts of poly(beta-hydroxybutyric acid), 4-6 parts of polyethylene, 40-60 parts of a filling supplement agent, 1-2 parts of a titanate coupling agent, 2-4 parts of sodium alginate, 4-8 parts of a plasticizer, and 1.5-2.5 parts of an UV531 anti-UV agent. The filling supplement agent includes bamboo fiber, precipitated barium sulfate, sepiolite powder, and calcined kaolin.Plasticizers include: dioctyl terephthalate, polyvinyl alcohol, hydroxy silicone oil, and disproportionated rosin. The modified microspheres are prepared by the following process: mixing 2,2-dimethoxy-2-phenylacetophenone ethanol solution, methacrylic acid mono-capped polyethylene glycol aqueous solution, and methyl methacrylate, stirring the mixture under nitrogen protection, and performing ultraviolet irradiation, centrifugation and drying to obtain the modified microspheres.

The claimed invention addresses the benefits of exogenous ketone supplementation in a subject in need thereof. In particular, the exogenous ketone supplementation includes the natural D-Beta HydroxyButyric acid, also described as natural D-BHB. As detailed in representative FIG. 1, natural D-BHB is preferentially consumed in the brain to glucose and additionally has a wide range of positive regulatory effects on the body and mind. Consumer applications for supplementation with natural D-BHB include improved sleep, anti-hunger, anti-anxiety, improved cognitive enhancement and athletic duration and post workout recovery through consumption of 10 grams or more of natural D-BHB. Therapeutic applications for exogenous natural D-BHB supplementation include anti-cancer, anti-kidney disease, anti-cognitive disorders and improved viral resistance through consumption of 10-20 grams or more of D-Beta HydroxyButyric acid.

The invention provides an application of beta hydroxybutyric acid in treatment of the Parkinson disease. The application provided by the invention has the advantages that proved by in-vitro and in-vivo pharmacological experiments, the beta hydroxybutyric acid has the effects of reducing oxidative stress of dopaminergic neurons of a Parkinson's disease model, reducing the apoptosis of the dopaminergic neurons and reducing the damage of the dopaminergic neurons of substantia nigra of a PD animal model so as to play a role in treating the Parkinson disease.

The production method of medical fibre uses beta-hydroxybutyric acid and beta-hydroxyvaleric acid as raw material, and adopts the following steps: drying, melting, extruding, conveying, metering and spraying, cooling, solidifying and forming, drawing and setting to obtain the invented finished product. Said invented medical fibre possesses long degradation time, can be used for making operative suture and medical auxiliary material for curing wound hard to healing.