Application of betulinic acid in promotion of fatty-acid oxidation

A technology of fatty acid oxidation and betulinic acid, applied in medical preparations containing active ingredients, digestive system, metabolic diseases, etc., can solve the problems of identification and judgment of long-term toxicity, increased energy consumption, etc., to reduce lipids Effects of deposition, improvement of fat metabolism, and weight loss of fat metabolism
CN108771682AInactive Publication Date: 2018-11-09SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
Publication Date
2018-11-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of betulinic acid in promotion of fatty-acid oxidation and particularly relates to the application of betulinic acid in preparation of medicines for preventing or treating related diseases of fatty-acid oxidation. The application disclosed by the invention has the beneficial effects that a fat C57 mouse with high-fat feeding for modeling is adopted as a researchobject, and the experimental result shows that the gene levels of the high-fat mouse treated by betulinic acid and the fatty-acid oxidation are respectively and obviously increased in different tissues, and the content of beta-hydroxybutyric acid (beta-OHB) in serum is also increased, i.e., betulinic acid can promote fatty-acid oxidation. Meanwhile, the body weight of the high-fat mouse treated by betulinic acid is obviously reduced; the application provides actual evidence of betulinic acid for treating obesity, non-alcoholic fatty liver disease (NAFLD) and other diseases related to the fatty-acid oxidation, has important scientific value and medical significance, and meanwhile can provide precious experiences for developing more natural-medicine active components for treating related diseases by promoting the fatty-acid oxidation.
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Description

technical field

[0001] The invention belongs to the field of medicine preparation, and in particular relates to the use of betulinic acid to prepare related medicines by promoting fatty acid oxidation. Background technique

[0002] The Global Obesity Report released by the World Health Organization in 2014 pointed out that obesity is now a global epidemic, and at least 2.8 million deaths each year can be attributed to overweight or obesity. The most commonly used measure of overweight and obesity in adults is body mass index (BMI), which is weight in kilograms divided by height in meters squared (kg / m^2). "Overweight" was defined as a body mass index ≥ 25, and "obese" was defined as a body mass index ≥ 30. The 2016 study published in The Lancet collected data from 1975 to 2014 and provided a full picture of BMI trends in adults. In the past 40 years, the number of obese people in the world has exploded: in 1975, it was only 105 million, and it rose to 641 million in 2014. ...

Claims

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