Application of beta-hydroxybutyric acid or pharmaceutically acceptable salt thereof

A technology of oxybutyric acid and pharmacy, applied in the field of medicine, can solve the problems of unresearched cardiovascular

Active Publication Date: 2015-09-30
ZHUKANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, does β-hydroxybutyrate affect ONOO, which plays a key role in diabetes? - , so as to play a cardiovascular protective role has not yet been studied

Method used

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  • Application of beta-hydroxybutyric acid or pharmaceutically acceptable salt thereof
  • Application of beta-hydroxybutyric acid or pharmaceutically acceptable salt thereof
  • Application of beta-hydroxybutyric acid or pharmaceutically acceptable salt thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In this example, the application of β-hydroxybutyric acid in the preparation of drugs for preventing and treating diabetes and its chronic complications includes: taking a medicinal amount of β-hydroxybutyric acid and mixing it with excipient starch to prepare a powder. The medicinal dosage of β-hydroxybutyric acid is 1-500mg / kg body weight.

Embodiment 2

[0030] In this example, the pharmaceutically acceptable salt of β-hydroxybutyric acid is used in the preparation of drugs for antagonizing oxidative stress and its nitration, including: taking a medicinal amount of β-hydroxybutyric acid sodium salt, and water for injection Mixed to prepare injection.

Embodiment 3

[0032] In this example, the application of β-hydroxybutyric acid in the preparation of a drug for inhibiting weight loss caused by diabetes includes: taking a medicinal amount of β-hydroxybutyric acid and mixing it with water for injection to prepare an injection.

[0033] In other embodiments of the present invention, a medicinal amount of sodium β-hydroxybutyrate may also be mixed with water for injection to prepare an injection. Medicinal dosage is all with embodiment 1. In this field, the preparation of powders and injections is a prior art and will not be repeated here.

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Abstract

The invention discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof, particularly discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing and treating diabetes mellitus and chronic complication thereof, and belongs to the technical field of medicines. A diabetes rat model is induced with streptozotocin (STZ); the prevention and treatment effects of the beta-hydroxybutyric acid on diabetes and chronic complication of rats are observed with the beta-hydroxybutyric acid through subcutaneous injection; the result shows that the weight loss of the rats can be restrained by the beta-hydroxybutyric acid; the pathology function change of chronic pancreas, great vessels, kidneys, hearts, livers and the like of the rats is improved; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof as an active pharmaceutical ingredient is combined with conventional additives in the field of medicines to prepare medicines; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof can be used for improving the diabetes and the chronic complication thereof; and clinical treatment is carried out by aiming at diseases caused by anti-oxidative stress and nitration injuries.

Description

technical field [0001] The invention specifically relates to the application of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof in the preparation of medicines for preventing and treating diabetes and its chronic complications, and belongs to the technical field of medicine. Background technique [0002] Diabetes mellitus is an endocrine disease characterized by persistent high blood sugar as its basic biochemical feature. Its harm has become a non-communicable disease second only to cardiovascular and cerebrovascular diseases and malignant tumors. Oxidative stress is considered to be a central link in the development of diabetes and its chronic complications (Sudhahar V, et al. 2013; Hernandez-Mijares A, et al. 2013). In diabetes, the key enzyme of oxidative stress response, inducible nitric oxide synthase (iNOS), is induced to synthesize excess nitric oxide (nitric oxide, NO). NO and O 2 .- Can react rapidly to form peroxynitrite anion ONOO - (pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P3/10A61P39/06
Inventor 齐锦生栗彦宁王秀娟刘昆李彬
Owner ZHUKANG BIOTECHNOLOGY CO LTD
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