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Prostaglandin microemulsion gel rubber preparation and method of producing the same

A prostaglandin and microemulsion gel technology, applied in the field of medicine, can solve the problems of inconvenient use of transdermal drug carriers and low viscosity of microemulsion systems

Inactive Publication Date: 2009-05-13
李淑斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low viscosity and strong fluidity of the microemulsion system, it is not convenient to use as a transdermal drug carrier

Method used

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  • Prostaglandin microemulsion gel rubber preparation and method of producing the same
  • Prostaglandin microemulsion gel rubber preparation and method of producing the same
  • Prostaglandin microemulsion gel rubber preparation and method of producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prostaglandin E1 0.2g

[0036] Refined soybean oil 10g

[0037] Lecithin 3g

[0038] Poloxamer 188 7g

[0039] Glycerin 10g

[0040] Vitamin C 0.2g

[0041] Methylcellulose 1g

[0042] Water for injection 68.6g

[0043]Preparation method: mix refined soybean oil and lecithin evenly to obtain an oil phase, add prostaglandin E1 into the oil phase to dissolve; disperse methylcellulose in water, swell overnight, then add poloxamer 188, glycerin and vitamin C , mixed uniformly to obtain a water phase; adding the oil phase to the water phase, stirred evenly, and filtered through a 0.22 μm microporous membrane to obtain a prostaglandin E1 microemulsion gel preparation.

Embodiment 2

[0045] Prostaglandin E1 0.5g

[0046] Ethyl oleate 8g

[0047] Polyoxyethylene castor oil 10g

[0048] Isopropanol 6g

[0049] Carbomer 0.5g

[0050] Triethanolamine 0.55g

[0051] Propylparaben 0.05g

[0052] Water for injection 74.4g

[0053] Preparation method: Mix ethyl oleate and polyoxyethylene castor oil evenly to obtain an oil phase, add prostaglandin E1 into the oil phase to dissolve; disperse carbomer in water, swell overnight, then add isopropanol, and mix evenly to obtain water phase; adding the oil phase to the water phase, stirring evenly to obtain a microemulsion; adding triethanolamine to the microemulsion, and mixing evenly to obtain the prostaglandin E1 microemulsion gel preparation.

Embodiment 3

[0055] Prostaglandin E1 0.8g

[0056] Isopropyl Palmitate 15g

[0057] Tween 80 12g

[0058] 1,2-propanediol 10g

[0059] Azone 5g

[0060] Disodium EDTA 0.05g

[0061] Hydroxypropyl Cellulose 3g

[0062] Water for injection 54.15g

[0063] Preparation method: mix isopropyl palmitate and azone evenly to obtain an oil phase, add prostaglandin E1 into the oil phase to dissolve; disperse hydroxypropyl cellulose in water, swell overnight, then add Tween 80, 1, 2 -Propylene glycol and disodium edetate are mixed evenly to obtain the water phase; the oil phase is added to the water phase, stirred evenly, and sterilized and filtered through a 0.22 μm microporous membrane to obtain the prostaglandin E1 microemulsion gel preparation.

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Abstract

The invention relates to prostaglandin microemulsion-gel preparation and a preparation method thereof. The preparation comprises prostaglandin E1 or the derivative thereof, oil, emulsifier, assistant for emulsifying agent, gel substrate and water, and also possibly comprises a permeation accelerator, a preparation stabilizer, an antioxidant and antiseptics. The preparation has the advantages of good percutaneous permeability, no stimulation to skin and mucous membrane, simple preparation technique and stable quality, the preparation can be used for treating diseases such as ulcer of limbs caused by erectile dysfunction and chronic arterial occlusion and rest pain of limbs caused by microcirculatory disturbance.

Description

technical field [0001] The invention relates to a prostaglandin microemulsion gel preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Prostaglandin E1 (PGE1) is also known as alprostadil, and its chemical name is: 11α, 15(S)-dihydroxy-9-keto-13-reverse prostenic acid. [0003] The chemical structural formula is: [0004] [0005] Molecular formula: C 20 h 34 o 5 [0006] Molecular weight: 354.48 [0007] Prostaglandin E1 is an important physiologically active substance in the human body. It has various physiological and pharmacological effects such as dilating blood vessels, inhibiting platelet aggregation, regulating inflammatory cell activity, reducing gastric juice secretion, and stimulating small intestine and uterine peristalsis. Clinically, it is widely used in the treatment of various cardiovascular and cerebrovascular diseases, male erectile dysfunction, severe peripheral vascular disease,...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/5575A61P7/02A61P9/00A61P15/10A61P11/00
Inventor 李淑斌马蕊魏晓莹张福生
Owner 李淑斌
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