57 results about "Drug eluting balloon" patented technology

The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.

The invention provides a medicine eluting balloon catheter, which comprises a balloon catheter body and a medicine coating, wherein the balloon catheter body comprises a balloon; the outside surface of the balloon has a plurality of grooves; and the medicine coating is coated on the grooved part and flat part of the outside surface of the balloon. The medicine eluting balloon catheter is characterized in that grooves protrude in a reversed direction when the balloon is fully expanded. The medicine eluting balloon catheter disclosed by the invention can carry more medicines and reduce loss of the medicines in a conveying process; and the medicine eluting balloon catheter directly pour and cast medicines remaining in the grooves into blood through reversed protrusion to accelerate the release of the medicines and to increase the medicine concentration at a target position, so that the medicines can quickly concentrate and act on the target position to well prevent the blood vessel tissue at the target position from regeneration and restenosis.

The invention provides a system and method for localized application of therapeutic substances within a biological lumen and to the wall of the lumen. In various embodiments, a biodegradable tubular prosthesis comprising a plurality of pores is deployed within a biological lumen. Subsequent to, or in conjunction with, the deployment of the prosthesis, a drug-eluting balloon comprising at least one therapeutic agent is expanded within the lumen of the tubular prosthesis, thereby releasing the agent(s) from the balloon and delivering them to the prosthesis pores. The at least one therapeutic agent is then allowed to diffuse through the pores to the lumen wall.

A drug-eluting balloon apparatus comprises a balloon surface (10), a polymer layer (14) that comprises drugs or both drugs and additives, and one or multiple drug layers or drug-and-additive layers (16). When a balloon (8) expands at a target lesion, the polymer layer (14) and the drug layers or the drug-and-additive layers (16) fall off the balloon surface (10) and bond on a blood vessel wall. The polymer layer (14) of the drug-eluting balloon apparatus can prevent a great loss of drugs during a pushing process of the balloon (8), and can also protect the drugs bond on the blood vessel wall from being brushed by blood, thus improving a drug utilization rate.

A drug-eluting balloon and a preparation method therefor. The drug-eluting balloon comprises a double-layer balloon, the outer surface whereof is sequentially coated with a water-soluble substrate and a biodegradable polymer layer containing a medicine. During the process of balloon dilatation, physiological saline and related solutions exude through the balloon wall and dissolve the water-soluble substrate, thereby controlling release of the degradable polymer layer containing the medicine.

The invention provides a novel drug eluting balloon catheter. The novel drug eluting balloon catheter comprises a catheter body, a balloon body (1) and a balloon surface (2) and further comprises a hydrophilic and lipophilic bottom layer (3) and a drug loading coating layer (4). The hydrophilic and lipophilic bottom layer (3) is arranged on the upper surface of the balloon surface (2), the drug loading coating layer (4) is arranged on the upper surface of the hydrophilic and lipophilic bottom layer (3), and the drug loading coating layer (4) is composed of polymer and drug. The novel drug eluting balloon catheter has the advantages of simple structure, simple production process and procedures, low drug loss during delivery and low drug residues on the balloon after interventional operation.

The invention discloses a stent and a medicine delivery device. The stent comprises a tubular stent body, one end of the stent body is provided with a connection structure for connection with a recovery device, and medicines are carried on the surface of the stent body. The medicine delivery device comprises the stent and the recovery device, the recovery device comprises a catheter sheath and a recovery wire, the recovery wire penetrates one end of the catheter sheath to be connected with the connection structure of the stent, and the catheter sheath is used for holding the stent after the stent is compressed. After the medicine carrying stent is implanted into a human body, a property of quickness of a medicine eluting balloon in medicine release is achieved while a supporting function of the stent is achieved as well, and the stent is recyclable, so that harms caused by long-time in-vivo retention of the stent are avoided.

The invention relates to a drug eluting balloon catheter and a preparation method thereof. A drug consists of drug particles different in particle size, and the surfaces of the drug particles are coated with phospholipids; a drug coating consists of two parts; the part, close to a balloon, of the coating consists of a phospholipid-coated drug and a hydrophilic excipient, and the part, on the outermost layer, of the coating consists of a hydrophobic or amphiphilic excipient. The coating on the outer side reduces the resistance of the balloon penetrating through a blood vessel to a target lesionand reduces the drug loss during transport; the coating close to the balloon promotes rapid release of the drug from the balloon surface and absorption of the drug by the target vessel, and the drugdiffused to an outer membrane can be continuously released to peripheral tissue to inhibit long-term restenosis. The drug eluting balloon catheter has a good application prospect in interventional therapy.

A drug eluting angioplasty balloon (1, 101) suitable to adopt a deployed configuration and a collapsed configuration, the balloon having an outer wall (10) disposed around a core (11) defining an axis (X). The balloon (1, 101) comprising in the collapsed configuration a plurality of folds (12, 12′, 112) that are laid in a tangential direction about the core (11) and form a plurality of cavities (13a, 13b, 113) loaded with a drug (14), the cavities (13a, 13b, 113) are comprised between the folds (12, 12′, 112), wherein the folds (12, 12′, 112) originates from distinct longitudinal lines (25, 25′, 125, 125′) along the outer wall (10), are arranged in pairs and are circumferentially wrapped about the core (11) in such a way that a fold of one pair overlaps an adjacent fold of another pair and are wrapped in opposite directions.

The invention relates to a method for loading drugs on a drug eluting balloon catheter. The method comprises the following steps: (1) swelling a balloon for 0.5-3 hours; (2) spraying a mixed liquid composed of therapeutic drugs, additives and a solvent onto the surface of the swelled balloon by adopting a vacuum spraying technology, and naturally drying by air for 10-30 minutes, wherein the weight ratio of the solvent, the therapeutic drugs and the additives in the mixed liquid is (10-90) to (0.5-30) to (5-60); and the solution for swelling the balloon in the step (1) is any one or more of methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, n-octyl acrylate and methyl benzoate. According to the method for loading drugs on the drug eluting balloon catheter, a drug coating can be uniform and firm, and drugs can be released quickly and stably.

The invention discloses a novel drug-eluting balloon catheter and a preparation method thereof. The drug-eluting balloon catheter consists of a catheter and a drug coating, wherein the drug coating consists of drug particles, an amphiphilic emulsifier and an excipient, and the drug particles wrapped by the amphiphilic emulsifier are uniformly dispersed in the excipient. The drug-eluting balloon catheter has effects of quickly releasing the drug, improving efficiency of transferring the drug into the blood vessel wall in a short time and improving the bioavailability, and has a good applicationprospect in interventional science.

The invention discloses a preparation method of medicine eluting balloons. The preparation method of the medicine eluting balloons is characterized by comprising the following steps: (1) soaking the balloons in an inorganic salt solution for 1 to 1.5 hours, taking out the balloons and drying; (2) adding water into a medicine solution, stirring uniformly, performing standing for 1 to 2 minutes, soaking the dried balloons in the step (1) into the medicine solution for 1 to 2 hours, taking out the balloons and drying to obtain the medicine eluting balloons. The inorganic salt aqueous solution is a sodium chloride-magnesium chloride mixed aqueous solution or a calcium chloride-magnesium chloride mixed aqueous solution; the medicine solution consists of a medicine, an additive and a solvent; the additive is PVP or PVA; the solvent is methanol or ethanol. On the basis of the prior art, the binding force of the medicines and the balloons can be enhanced, the medicine coating is uniform, the medicine effect is durable, the granularity of the coating is controlled, and the aims of controlling the medicine release degree, reducing thrombogenesis and reducing vascular occlusion possibility are fulfilled.

The invention relates to a drug eluting balloon catheter and a preparation method thereof, and relates to the field of medical instruments. The balloon catheter comprises a balloon catheter body and acompacting drug layer which covers the outer surface of the balloon catheter body, the raw materials of the compacting drug layer comprise an active drug, a carrier and a solvent, the active drug isselected from at least one of the paclitaxel, paclitaxel derivative, rapamycin and rapamycin derivative, the carrier is selected from at least one of the calcium disodium edetate, iohexol, ioversol, iopamidol, anhydrous glucose, sodium chloride, dextran, sodium lactate, calcium chloride and potassium chloride sequentially, the mass ratio of the active drug to the carrier is 20:1-1:2, the catheteris provided with the compacting drug layer with lower releasing rate, and therefore the losing amount of the active drug in the delivery process is effectively reduced. The method has the advantages of being simple to operate and controllable, the catheter is conveniently produced in large batches, and the compacting level of the compacting drug layer of the drug eluting balloon catheter preparedby means of the method is improved.

The invention relates to a drug eluting balloon. The drug eluting balloon comprises a balloon body, wherein the middle of the balloon body is cylindrical, the two ends of the balloon body are conical, one end of the balloon body is connected with a connecting pipe through a guide pipe, a plurality of pits are formed in the outer wall of the cylindrical middle portion of the balloon body, the elasticity modulus of each pit is smaller than the elasticity modulus of the balloon body, the elasticity modulus difference meets the conditions that the pits sink towards the interior of the balloon body when the balloon body is filled with no filing medium and the pits protrude towards the outside of the balloon body when the balloon body is filled with filling media, and by the adoption of the design, the superficial area of the balloon is increased, drug adhesion is improved, drugs are ejected in the form of a drug pill when the balloon expands, and it is guaranteed that drugs are released fully in a short time. According to the drug eluting balloon, a special structure is adopted, the drug loading capacity is improved based on a traditional drug balloon, and drugs are released fully through ejection; after the drug balloon is used, the defects of a drug support can be effectively overcome, a patient just needs to take duplex antiplatelet drugs conventionally in a short time, and the metal burden and the economical burden of the patient are greatly reduced.

The current invention relates to the provision of drug eluting balloons and balloon catheters, where the drug coating is protected by one or more sheaths and/or is applied to an elastic film, rather than to the balloon directly.