58 results about "Drug eluting balloon" patented technology

The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.

A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the overall plaque site.

The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.

There is disclosed a drug eluting balloon catheter assembly provided with a balloon formed of an inner balloon member of non-compliant material and an outer balloon member of a compliant material and which is provided with holes therein for eluting a drug or other fluid. In use, the outer balloon member is biased by contraction onto the inner balloon member thereby keeping the holes therein normally sealed closed and minimizing dead space in the device.

The invention provides a medicine eluting balloon catheter, which comprises a balloon catheter body and a medicine coating, wherein the balloon catheter body comprises a balloon; the outside surface of the balloon has a plurality of grooves; and the medicine coating is coated on the grooved part and flat part of the outside surface of the balloon. The medicine eluting balloon catheter is characterized in that grooves protrude in a reversed direction when the balloon is fully expanded. The medicine eluting balloon catheter disclosed by the invention can carry more medicines and reduce loss of the medicines in a conveying process; and the medicine eluting balloon catheter directly pour and cast medicines remaining in the grooves into blood through reversed protrusion to accelerate the release of the medicines and to increase the medicine concentration at a target position, so that the medicines can quickly concentrate and act on the target position to well prevent the blood vessel tissue at the target position from regeneration and restenosis.

A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of barbs or anchoring points on its outer annular periphery. The annular band has a length in the axial direction of the blood vessel walls that is about equal to or less than its diameter as installed in the blood vessel. In a preferred embodiment, the tack device is formed as a compressible metallic mesh band having outer barbs on outer sides of the mesh structure. Another embodiment may have a plurality of compressible mesh bands may be formed spaced apart coaxially from each other and connected by longitudinally extending bridge members. A preferred method is to perform angioplasty with a drug eluting balloon as a first step, and if there is any dissection to the blood vessel caused by the balloon angioplasty, one or more tack devices may be installed to tack down the dissected area of the blood vessel surface, in order to avoid the need to install a stent and thereby maintain a ‘stent-free’ environment.

A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of barbs or anchoring points on its outer annular periphery. The annular band has a length in the axial direction of the blood vessel walls that is about equal to or less than its diameter as installed in the blood vessel. In a preferred embodiment, the tack device is formed as a compressible metallic mesh band having outer barbs on outer sides of the mesh structure. Another embodiment may have a plurality of compressible mesh bands may be formed spaced apart coaxially from each other and connected by longitudinally extending bridge members. A preferred method is to perform angioplasty with a drug eluting balloon as a first step, and if there is any dissection to the blood vessel caused by the balloon angioplasty, one or more tack devices may be installed to tack down the dissected area of the blood vessel surface, in order to avoid the need to install a stent and thereby maintain a ‘stent-free’ environment.

The invention provides a system and method for localized application of therapeutic substances within a biological lumen and to the wall of the lumen. In various embodiments, a biodegradable tubular prosthesis comprising a plurality of pores is deployed within a biological lumen. Subsequent to, or in conjunction with, the deployment of the prosthesis, a drug-eluting balloon comprising at least one therapeutic agent is expanded within the lumen of the tubular prosthesis, thereby releasing the agent(s) from the balloon and delivering them to the prosthesis pores. The at least one therapeutic agent is then allowed to diffuse through the pores to the lumen wall.

A drug-eluting balloon apparatus comprises a balloon surface (10), a polymer layer (14) that comprises drugs or both drugs and additives, and one or multiple drug layers or drug-and-additive layers (16). When a balloon (8) expands at a target lesion, the polymer layer (14) and the drug layers or the drug-and-additive layers (16) fall off the balloon surface (10) and bond on a blood vessel wall. The polymer layer (14) of the drug-eluting balloon apparatus can prevent a great loss of drugs during a pushing process of the balloon (8), and can also protect the drugs bond on the blood vessel wall from being brushed by blood, thus improving a drug utilization rate.

A drug-eluting balloon and a preparation method therefor. The drug-eluting balloon comprises a double-layer balloon, the outer surface whereof is sequentially coated with a water-soluble substrate and a biodegradable polymer layer containing a medicine. During the process of balloon dilatation, physiological saline and related solutions exude through the balloon wall and dissolve the water-soluble substrate, thereby controlling release of the degradable polymer layer containing the medicine.

The invention provides a novel drug eluting balloon catheter. The novel drug eluting balloon catheter comprises a catheter body, a balloon body (1) and a balloon surface (2) and further comprises a hydrophilic and lipophilic bottom layer (3) and a drug loading coating layer (4). The hydrophilic and lipophilic bottom layer (3) is arranged on the upper surface of the balloon surface (2), the drug loading coating layer (4) is arranged on the upper surface of the hydrophilic and lipophilic bottom layer (3), and the drug loading coating layer (4) is composed of polymer and drug. The novel drug eluting balloon catheter has the advantages of simple structure, simple production process and procedures, low drug loss during delivery and low drug residues on the balloon after interventional operation.

The invention discloses a drug eluting balloon system which comprises a balloon catheter and a drug eluting balloon, wherein the balloon catheter is provided with a wire guide cavity arranged along the axial direction; the drug eluting balloon is arranged along the partial length of the balloon catheter and is expanded by virtue of a pressure medium provided by the balloon catheter; the external surface of the balloon body of the drug eluting balloon is provided with a drug coating; the drug coating comprises an inner layer and an outer layer, wherein the inner layer is a taxol and hirudin mixed drug coating, and the outer layer is a hirudin drug coating; a flow channel is also arranged in the wire guide cavity, and the flow channel is arranged at the partial length position of the balloon catheter; and the flow channel is provided with two openings which are respectively formed in two ends of the drug eluting balloon. When the drug eluting balloon system releases drugs, blood flow can not be blocked and drug release can be prolonged to any time, so that the action time of the drugs is increased and the curative effect is improved.

The invention discloses a stent and a medicine delivery device. The stent comprises a tubular stent body, one end of the stent body is provided with a connection structure for connection with a recovery device, and medicines are carried on the surface of the stent body. The medicine delivery device comprises the stent and the recovery device, the recovery device comprises a catheter sheath and a recovery wire, the recovery wire penetrates one end of the catheter sheath to be connected with the connection structure of the stent, and the catheter sheath is used for holding the stent after the stent is compressed. After the medicine carrying stent is implanted into a human body, a property of quickness of a medicine eluting balloon in medicine release is achieved while a supporting function of the stent is achieved as well, and the stent is recyclable, so that harms caused by long-time in-vivo retention of the stent are avoided.

The invention relates to a drug eluting balloon catheter and a preparation method thereof. A drug consists of drug particles different in particle size, and the surfaces of the drug particles are coated with phospholipids; a drug coating consists of two parts; the part, close to a balloon, of the coating consists of a phospholipid-coated drug and a hydrophilic excipient, and the part, on the outermost layer, of the coating consists of a hydrophobic or amphiphilic excipient. The coating on the outer side reduces the resistance of the balloon penetrating through a blood vessel to a target lesionand reduces the drug loss during transport; the coating close to the balloon promotes rapid release of the drug from the balloon surface and absorption of the drug by the target vessel, and the drugdiffused to an outer membrane can be continuously released to peripheral tissue to inhibit long-term restenosis. The drug eluting balloon catheter has a good application prospect in interventional therapy.

A drug eluting angioplasty balloon (1, 101) suitable to adopt a deployed configuration and a collapsed configuration, the balloon having an outer wall (10) disposed around a core (11) defining an axis (X). The balloon (1, 101) comprising in the collapsed configuration a plurality of folds (12, 12′, 112) that are laid in a tangential direction about the core (11) and form a plurality of cavities (13a, 13b, 113) loaded with a drug (14), the cavities (13a, 13b, 113) are comprised between the folds (12, 12′, 112), wherein the folds (12, 12′, 112) originates from distinct longitudinal lines (25, 25′, 125, 125′) along the outer wall (10), are arranged in pairs and are circumferentially wrapped about the core (11) in such a way that a fold of one pair overlaps an adjacent fold of another pair and are wrapped in opposite directions.

The invention relates to a method for loading drugs on a drug eluting balloon catheter. The method comprises the following steps: (1) swelling a balloon for 0.5-3 hours; (2) spraying a mixed liquid composed of therapeutic drugs, additives and a solvent onto the surface of the swelled balloon by adopting a vacuum spraying technology, and naturally drying by air for 10-30 minutes, wherein the weight ratio of the solvent, the therapeutic drugs and the additives in the mixed liquid is (10-90) to (0.5-30) to (5-60); and the solution for swelling the balloon in the step (1) is any one or more of methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, n-octyl acrylate and methyl benzoate. According to the method for loading drugs on the drug eluting balloon catheter, a drug coating can be uniform and firm, and drugs can be released quickly and stably.

The invention discloses a novel drug-eluting balloon catheter and a preparation method thereof. The drug-eluting balloon catheter consists of a catheter and a drug coating, wherein the drug coating consists of drug particles, an amphiphilic emulsifier and an excipient, and the drug particles wrapped by the amphiphilic emulsifier are uniformly dispersed in the excipient. The drug-eluting balloon catheter has effects of quickly releasing the drug, improving efficiency of transferring the drug into the blood vessel wall in a short time and improving the bioavailability, and has a good applicationprospect in interventional science.

The invention discloses a medicine eluting balloon catheter with a function of thrombus aspiration and vasodilatation, and belongs to the field of medical device. The catheter structure comprises a balloon cavity 1, an auxiliary cavity 2, a RX port 3, a guide wire cavity 4, a developing ring 5, a suction cavity 6 and a Y-type connector 7. The balloon cavity is in the outermost layer of the suctioncatheter, the auxiliary cavity 2 is on the inner wall of the suction cavity 6, and the guide wire cavity 4 is on the distal end inner wall of the suction cavity 6. The medicine eluting balloon catheter is used for medicine thrombolysis by injecting thrombolytic medicine into the suction cavity 6. The invention of the medicine eluting balloon catheter is set an auxiliary chamber on the inner wallof the suction cavity 6, applying the improved in vitro ultrasonic assisted thrombolysis (ETUS) function, and a small metal microporous cylinder is placed in human body by the auxiliary cavity 2 conveying system; the medicine eluting balloon catheter reflects multiple direction ultrasonic wave through in vitro ultrasonic probe ultrasound and porous cylinder to amplify ultrasonic cavitation effect,improving the efficiency of broken bolt, and feeds into the interference wire through the auxiliary cavity 2 to break the bolt with mechanical force.

The invention provides a system and method for localized application of therapeutic substances within a biological lumen and to the wall of the lumen. In various embodiments, a biodegradable tubular prosthesis comprising a plurality of pores is deployed within a biological lumen. Subsequent to, or in conjunction with, the deployment of the prosthesis, a drug-eluting balloon comprising at least one therapeutic agent is expanded within the lumen of the tubular prosthesis, thereby releasing the agent(s) from the balloon and delivering them to the prosthesis pores. The at least one therapeutic agent is then allowed to diffuse through the pores to the lumen wall.

The invention discloses a preparation method of medicine eluting balloons. The preparation method of the medicine eluting balloons is characterized by comprising the following steps: (1) soaking the balloons in an inorganic salt solution for 1 to 1.5 hours, taking out the balloons and drying; (2) adding water into a medicine solution, stirring uniformly, performing standing for 1 to 2 minutes, soaking the dried balloons in the step (1) into the medicine solution for 1 to 2 hours, taking out the balloons and drying to obtain the medicine eluting balloons. The inorganic salt aqueous solution is a sodium chloride-magnesium chloride mixed aqueous solution or a calcium chloride-magnesium chloride mixed aqueous solution; the medicine solution consists of a medicine, an additive and a solvent; the additive is PVP or PVA; the solvent is methanol or ethanol. On the basis of the prior art, the binding force of the medicines and the balloons can be enhanced, the medicine coating is uniform, the medicine effect is durable, the granularity of the coating is controlled, and the aims of controlling the medicine release degree, reducing thrombogenesis and reducing vascular occlusion possibility are fulfilled.

The invention relates to a drug eluting balloon catheter and a preparation method thereof, and relates to the field of medical instruments. The balloon catheter comprises a balloon catheter body and acompacting drug layer which covers the outer surface of the balloon catheter body, the raw materials of the compacting drug layer comprise an active drug, a carrier and a solvent, the active drug isselected from at least one of the paclitaxel, paclitaxel derivative, rapamycin and rapamycin derivative, the carrier is selected from at least one of the calcium disodium edetate, iohexol, ioversol, iopamidol, anhydrous glucose, sodium chloride, dextran, sodium lactate, calcium chloride and potassium chloride sequentially, the mass ratio of the active drug to the carrier is 20:1-1:2, the catheteris provided with the compacting drug layer with lower releasing rate, and therefore the losing amount of the active drug in the delivery process is effectively reduced. The method has the advantages of being simple to operate and controllable, the catheter is conveniently produced in large batches, and the compacting level of the compacting drug layer of the drug eluting balloon catheter preparedby means of the method is improved.

The invention discloses a drug-eluting-balloon catheter system with vibration. The system comprises a slender component and an expandable balloon, wherein the interior of the balloon is hollow and isprovided with a vibration structural unit; the surface of the exterior of the balloon is covered with a drug; when the balloon is fully expanded, the drug covering the surface is in contact with a vessel wall; the balloon enters a vibration state; the slender component is inside provided with a lumen; the lumen is communicated with the interior of the balloon, and is filled with gas or liquid; preferably, the drug-eluting-balloon catheter system also comprises a vibration source based on an ultrasonic or electrohydraulic effect; after the balloon is in a fully expanded state, the drug on the surface of the balloon is about to cling to the vessel wall; afterwards, the drug is promoted to be absorbed by the vibration. The drug-eluting-balloon catheter system can be used for enabling the drugon a drug eluting balloon to be better and more quickly absorbed by the vessel wall of a human body, and the treatment effect is improved.

A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5 degrees of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.

The embodiment of the invention discloses a drug-eluting balloon dilatation catheter. The drug-eluting balloon dilatation catheter includes a dual-lumen catheter and a dual-lumen catheter seat connected to one end of the dual-lumen catheter, a drug balloon is connected to the other end of the dual-lumen catheter, a drug coating is arranged on the surface of the drug balloon, the dual-lumen catheter seat communicates with the drug balloon through the dual-lumen catheter, and a protection sleeve which can move relative to the dual-lumen catheter and the drug balloon and is used for restraining the drug balloon is arranged on the outer side of the drug balloon in a sleeving mode. The drug-eluting balloon dilatation catheter is provided with the protection sleeve, when the balloon is insertedinto a blood vessel, since the protection sleeve is connected to the surface of the balloon in a sleeving mode so that the balloon cannot be directly washed by blood, when the balloon with the drug extends into a blood vessel with vascular disease of a patient, the balloon is exposed from the protection sleeve and filled and tightly attached to the diseased blood vessel, so that the treatment operation is performed, the operation process is simple and convenient, and the loss of drug amount due to the friction between the inner wall of the blood vessel and the drug on the surface of the balloon is further avoided.

The invention relates to a drug eluting balloon. The drug eluting balloon comprises a balloon body, wherein the middle of the balloon body is cylindrical, the two ends of the balloon body are conical, one end of the balloon body is connected with a connecting pipe through a guide pipe, a plurality of pits are formed in the outer wall of the cylindrical middle portion of the balloon body, the elasticity modulus of each pit is smaller than the elasticity modulus of the balloon body, the elasticity modulus difference meets the conditions that the pits sink towards the interior of the balloon body when the balloon body is filled with no filing medium and the pits protrude towards the outside of the balloon body when the balloon body is filled with filling media, and by the adoption of the design, the superficial area of the balloon is increased, drug adhesion is improved, drugs are ejected in the form of a drug pill when the balloon expands, and it is guaranteed that drugs are released fully in a short time. According to the drug eluting balloon, a special structure is adopted, the drug loading capacity is improved based on a traditional drug balloon, and drugs are released fully through ejection; after the drug balloon is used, the defects of a drug support can be effectively overcome, a patient just needs to take duplex antiplatelet drugs conventionally in a short time, and the metal burden and the economical burden of the patient are greatly reduced.