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Preparation method of medicine eluting balloons

A drug and balloon technology, which is applied in the direction of drug devices, catheters, and other medical devices, can solve the problem that drug coatings are difficult to maintain a high degree of binding and a suitable release particle size at the same time, so as to maintain mechanical properties and service life , Reduce the possibility of blood vessel blockage, the effect of simple steps

Active Publication Date: 2017-06-06
ZHEJIANG BARTY MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug coating on the surface of the balloon obtained by this method is difficult to maintain a high degree of binding and a suitable release particle size

Method used

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  • Preparation method of medicine eluting balloons
  • Preparation method of medicine eluting balloons
  • Preparation method of medicine eluting balloons

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Soak the 4.0mm*60mm balloon in 15mL sodium chloride-magnesium chloride mixed aqueous solution (the concentration of sodium chloride is 15mg / mL, the concentration of magnesium chloride is 10mg / mL) for 1 hour, take it out and dry it;

[0020] (2) Add water to 15mL paclitaxel-PVP mixed solution (the concentration of paclitaxel is 40mg / mL, the mass ratio of paclitaxel and PVP is 1:1.5, PVP molecular weight 3000, solvent is methanol), the volume ratio of medicine solution and water is 8:1, stir evenly and let stand for 1 minute; then immerse the dried balloon in step (1) in the drug solution for 2 hours, take out the balloon and dry it to obtain the drug-eluting balloon.

Embodiment 2

[0022] The steps are the same as those in Example 1, except that the dosages of the sodium chloride-magnesium chloride mixed aqueous solution and the drug solution are both 20 mL.

Embodiment 3

[0024] The steps are the same as those in Example 1, except that the dosages of the sodium chloride-magnesium chloride mixed aqueous solution and the drug solution are both 25 mL.

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Abstract

The invention discloses a preparation method of medicine eluting balloons. The preparation method of the medicine eluting balloons is characterized by comprising the following steps: (1) soaking the balloons in an inorganic salt solution for 1 to 1.5 hours, taking out the balloons and drying; (2) adding water into a medicine solution, stirring uniformly, performing standing for 1 to 2 minutes, soaking the dried balloons in the step (1) into the medicine solution for 1 to 2 hours, taking out the balloons and drying to obtain the medicine eluting balloons. The inorganic salt aqueous solution is a sodium chloride-magnesium chloride mixed aqueous solution or a calcium chloride-magnesium chloride mixed aqueous solution; the medicine solution consists of a medicine, an additive and a solvent; the additive is PVP or PVA; the solvent is methanol or ethanol. On the basis of the prior art, the binding force of the medicines and the balloons can be enhanced, the medicine coating is uniform, the medicine effect is durable, the granularity of the coating is controlled, and the aims of controlling the medicine release degree, reducing thrombogenesis and reducing vascular occlusion possibility are fulfilled.

Description

technical field [0001] The invention relates to the technical field of medical device preparation, in particular to a preparation method of a drug-eluting balloon. Background technique [0002] The drug-eluting balloon is an interventional medical device. After the drug is delivered in the blood vessel, it is withdrawn from the blood vessel, and the drug stays in the lesion. Through the continuous release of the drug, it can inhibit the stenosis of the blood vessel. This is a very ideal new medical device. , has become a new research hotspot in the field of vascular intervention. [0003] The Chinese invention application document "Preparation Method of Drug Coating for Balloon Dilatation Catheter for Therapy" (publication number CN104324421A) points out that there are many factors that affect the drug delivery effect of the drug eluting balloon, such as the content and distribution of the drug on the surface of the balloon , Drug loss during delivery, ability of drug to tr...

Claims

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Application Information

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IPC IPC(8): A61L29/10A61L29/08A61L29/16A61M31/00
CPCA61L29/085A61L29/106A61L29/16A61L2300/416A61L2300/602A61L2300/606A61M31/00A61M2210/12C08L39/06C08L29/04
Inventor 季培红刘杨陈静何旭林王成李丹平
Owner ZHEJIANG BARTY MEDICAL TECH CO LTD
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