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Stent and medicine delivery device

A technology for delivering devices and drugs, which is applied to stents, devices for drugs, devices for human tubular structures, etc., can solve problems such as difficult to achieve, unsatisfactory effects, and difficult development, and achieve the effect of preventing the elastic retraction of blood vessels

Inactive Publication Date: 2016-11-09
SHANGHAI VASOLUTIONS MEDTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, DEB also faces certain difficulties in practical application, that is, it is difficult to achieve sufficient adhesion of the drug to the balloon to reduce the loss of the drug during delivery, and to ensure that a sufficient amount is released when the balloon expands at the target site. The drug can be delivered to the diseased tissue to play a therapeutic role
[0005] At present, in the research and development of drug stents, most researchers use degradable polymers or do not add polymers to reduce or avoid the long-term side effects of polymers on the human body, but the long-term existence of stents has not been well understood for the time being. Solve; degradable stents are one of the current research hotspots, but compared with metal stents, degradable stents have defects such as easy fracture and weak support, which also limit their application in some aspects
In the research and development of drug balloons, researchers mostly solve the problems faced by drug balloons by designing special balloon structures or developing carriers with special properties. question

Method used

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  • Stent and medicine delivery device
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  • Stent and medicine delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] See figure 1 The stent 1100 provided in this embodiment includes a tubular stent body braided in a "W" shape by a plurality of nickel-titanium alloy wires, the weaving density of the tubular stent body gradually decreases from one end to the other end, wherein the loose ends form the connecting structure of the bracket 1100, from figure 1 It can be seen from the figure that the connection structure includes a plurality of connection terminals.

[0031] Dissolve 75mg of paclitaxel and 45mg of polyurea in 2-4ml of acetone and ethanol to form a mixed solution, spray the above mixed solution on the surface of the stent main body, and dry to obtain the drug coating 1300, thereby forming a drug-loaded stent.

[0032] The stent 1100 of this embodiment is a recyclable stent, which can be used in conjunction with a recovery device during use. In this embodiment, the recovery device includes an introducer sheath 1220 (see figure 2 ) and a recycling wire 1210, one end of the...

Embodiment 2

[0039] See image 3 The stent 1110 provided in this embodiment includes a tubular stent body braided by four nickel-titanium wires using the Coil braiding method. Similar to Example 1, the braiding density of the tubular stent body gradually increases from one end to the other. loose, wherein the loose end forms a connecting structure 1111 with four pull rings.

[0040] Dissolve 300 mg of sodium alginate and 20 mg of chitosan in 10 ml of purified water, heat to 50°C, add 0.1 ml of glycerin, stir evenly for 2 hours, and degas under vacuum to obtain a degassed liquid. Coat a layer of Tween 80 on the glass plate, then evenly spray paclitaxel in ethanol solution, and let it stand for 30 minutes. Pour the degassed liquid into the above glass plate, and cast it into a film. Dry the glass plate in an oven at 50 degrees for 4 hours, and remove the film. Promptly obtain the absorbable film 1310 with medicine, see Figure 4 .

[0041] The above film 1310 is electrostatically bonded...

Embodiment 3

[0048] See Figure 10 and Figure 11 The stent main body 350 and the stent connection structure 450 are formed by laser engraving and heat treatment expansion of the nickel-titanium pipe. The stent main body 350 is a mesh structure, and the mesh between the stent body 350 and the stent connection structure 450 is a network with dense and gradually sparse mesh. The wedge-shaped transition structure 360. The wedge-shaped transition structure 360 ​​makes it easier for the stent to be folded and pulled into the catheter.

[0049] See Figure 11 , suture the latex film 100 inside the stent, the stent connection structure 450 and the wedge-shaped transition structure 360 ​​do not sew the film;

[0050] Dissolving 75 mg of paclitaxel and 45 mg of polyurea in 2-4 ml of acetone and ethanol to form a mixed solution, spraying the mixed solution on the surface of the membrane, and drying to obtain the stent graft with the drug layer 200;

[0051] Please continue to see Figure 12 , th...

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Abstract

The invention discloses a stent and a medicine delivery device. The stent comprises a tubular stent body, one end of the stent body is provided with a connection structure for connection with a recovery device, and medicines are carried on the surface of the stent body. The medicine delivery device comprises the stent and the recovery device, the recovery device comprises a catheter sheath and a recovery wire, the recovery wire penetrates one end of the catheter sheath to be connected with the connection structure of the stent, and the catheter sheath is used for holding the stent after the stent is compressed. After the medicine carrying stent is implanted into a human body, a property of quickness of a medicine eluting balloon in medicine release is achieved while a supporting function of the stent is achieved as well, and the stent is recyclable, so that harms caused by long-time in-vivo retention of the stent are avoided.

Description

technical field [0001] The invention belongs to the field of implantable medical devices, in particular to an implantable drug-eluting stent and a corresponding drug delivery device. Background technique [0002] Percutaneous coronary intervention refers to the use of percutaneous puncture technology to send balloon catheters or other related devices to remove coronary artery stenosis or obstruction and rebuild coronary blood flow. Currently commonly used interventional devices include bare balloons, cutting balloons, bare stents, and drug-eluting stents. These devices have achieved good results in the treatment of stenotic lesions, but each has some shortcomings. [0003] Drug-eluting stents (DES) are coated on the surface of the stent after mixing the drug with a polymer matrix to form a local drug-eluting system. After the stent is implanted in the blood vessel, the drug will be slowly released for several weeks to several months. With the support of the stent, it can e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/07A61F2/90A61F2/966A61M31/00
CPCA61F2/0077A61F2/07A61F2/90A61F2/966A61M31/00A61F2002/9528A61F2002/9665A61F2002/9511A61M2210/12A61F2250/0015A61F2250/0059A61F2250/0067
Inventor 李中华陈忠张琳琳郭芳韩建超张鹏苗铮华
Owner SHANGHAI VASOLUTIONS MEDTECH CO LTD
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