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Method for loading drugs on drug eluting balloon catheter

A balloon catheter and drug technology, applied in the field of medical devices, can solve the problems of difficult and rapid release, infirmity, uneven drug loading, etc., and achieve the effect of rapid and stable drug release and uniform drug coating

Active Publication Date: 2014-12-03
LIAONING YINYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned drug loading methods have the problems of uneven drug loading, looseness, easy fall off, and difficulty in rapid release. In order to improve the performance of drug balloons, it is necessary to seek a breakthrough in the combination of the balloon surface and the drug coating.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A drug-loading method for a drug-eluting balloon catheter, comprising the following steps:

[0024] ① Swell the balloon first: immerse the balloon in the solution for 1 hour to make it swell. The solutions used for balloon swelling were methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, octyl acrylate and benzene Any one of methyl formate, or a mixture of two or more of them.

[0025] ② Prepare a mixed solution containing therapeutic drugs, additives, and solvents; place the swollen balloon on a vacuum spraying device, apply the mixed solution on the surface of the balloon using vacuum spraying technology, and let it dry naturally for 10 minutes. in:

[0026] The weight-number ratio of solvent, therapeutic drug and additive in the mixed liquid is 10-90:0.5-30:5-60.

[0027] The therapeutic drug is any one of paclitaxel, rapamycin and derivatives of the two drugs, or a mixture of two or mo...

Embodiment 2

[0034] The difference between this embodiment and embodiment 1 is:

[0035] The solution used for swelling the balloon in step ① is methyl acetate, and the immersion time for swelling is 30 minutes.

[0036] The solvent of the mixed solution prepared in step ② is acetonitrile aqueous solution, the fat-soluble drug is rapamycin, the additive is acrylic acid, and the natural air-drying time is 30 minutes. The mass concentration of acetonitrile aqueous solution is 90%.

[0037] The weight-number ratio of the acetonitrile aqueous solution, rapamycin, and acrylic acid is 90:0.5:5.

Embodiment 3

[0039] The difference between this embodiment and embodiment 1 is:

[0040] The solution used for swelling the balloon in step ① is ethyl acetate, and the immersion time for swelling is 1 hour.

[0041] The solvent of the mixed solution prepared in step ② is acetone aqueous solution, the fat-soluble drug is paclitaxel, the additive is UV glue, and the natural air-drying time is 25 minutes. The mass concentration of acetone aqueous solution is 60%.

[0042] The ratio of parts by weight of acetone aqueous solution, paclitaxel and UV glue is 50:15:30.

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PUM

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Abstract

The invention relates to a method for loading drugs on a drug eluting balloon catheter. The method comprises the following steps: (1) swelling a balloon for 0.5-3 hours; (2) spraying a mixed liquid composed of therapeutic drugs, additives and a solvent onto the surface of the swelled balloon by adopting a vacuum spraying technology, and naturally drying by air for 10-30 minutes, wherein the weight ratio of the solvent, the therapeutic drugs and the additives in the mixed liquid is (10-90) to (0.5-30) to (5-60); and the solution for swelling the balloon in the step (1) is any one or more of methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, n-octyl acrylate and methyl benzoate. According to the method for loading drugs on the drug eluting balloon catheter, a drug coating can be uniform and firm, and drugs can be released quickly and stably.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug-loading method for a drug-eluting balloon catheter used in angioplasty. Background technique [0002] Since the first clinical application of percutaneous transluminal coronary angioplasty by Gruntzig in 1977, intravascular restenosis has been the main focus of debate in the treatment of PTCA. The application of drug-eluting stents has effectively solved this problem and has become another milestone in the history of percutaneous coronary intervention. However, in-stent restenosis caused by drug-eluting stents is extremely difficult to treat. If drug-eluting stents are inserted again, the probability of secondary restenosis is as high as 43%, and patients treated with drug-eluting stents need to take longer Dual antiplatelet drugs can prevent stent thrombosis; in addition, in special lesions such as small-diameter vascular lesions, long vascular lesions, and bifurca...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/16
Inventor 董何彦徐立霞卢春兰杜旭东杨刚
Owner LIAONING YINYI BIOTECH CO LTD
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