24 results about "O-Phthalaldehyde" patented technology

The invention relates to a diyne functionalized covalent organic framework material as well as a preparation method and application thereof, and the diyne functionalized covalent organic framework material is synthesized by taking 4, 4 ', 4', 4 ''-(pyrene-1, 3, 6, 8-tetrayl) tetraphenylamine and 5, 5 '-(butyl-1, 3-diyne-1, 4-diyl) diisophthalaldehyde as construction units and adopting a Schiff base reaction. The dialkynyl functionalized covalent organic framework material disclosed by the invention has good chemical stability and can be used as a carrier to controllably grow silver nanoparticles through metal coordination to obtain a composite material, and the composite material shows excellent catalytic activity and cycling stability in a 4-nitrophenol reduction reaction catalyzed by sodium borohydride; therefore, the method has important application potential in the fields of environmental restoration, green chemistry and the like.

The invention belongs to the technical field of disinfectants and discloses a high-level disinfectant and a preparation method thereof.The high-level disinfectant is prepared from, by mass, 0.1%-3% of phthalic dicarboxaldehyde, 0.2%-0.8% of chelating agent, 2%-5% of penetrating agent, 0.3%-2% of modified starch, 1%-2% of acrylic polymer, 0.1%-0.3% of single-chain quaternary ammonium salt, 0.1%-0.3% of double-chain quaternary ammonium salt, 0.4%-5% of corrosion inhibitor and the balance purified water. Modified starch and polyacrylic acid are fully dissolved in a high-temperature stage, molecular chains are fully expanded, more active sites are exposed, and then the temperature is gradually reduced, so that the molecular chains are orderly arranged, a compact and uniform network structure is formed, and effective release of bactericidal components is ensured. Meanwhile, the single-chain quaternary ammonium salt and the double-chain quaternary ammonium salt are complementary through membrane destruction and internal destruction respectively and have a synergistic effect with the o-phthalaldehyde, so that the sterilization effect is remarkably improved.

A method for measuring the concentration of phthalic dicarboxaldehyde (OPA) in a sample is provided. The method includes measuring the absorbance of the OPA at a specific wavelength using a spectrophotometer, and converting the absorbance value as a function of temperature (slope) into a concentration value using a standard curve. The methods are specific (selective), simple, rapid, and highly accurate, making them suitable for use in various applications, such as monitoring OPA concentrations in disinfection / sterilization industrial environments.

The invention relates to the technical field of o-phthalaldehyde disinfectants, and discloses o-phthalaldehyde disinfectant preparation equipment and a preparation method thereof.The o-phthalaldehyde disinfectant preparation equipment comprises a base, a processing barrel fixedly connected to the top end of the base, a liquid drainage pipe fixedly connected to the bottom end of the processing barrel in a penetrating mode, and a water injection pipe fixedly connected to the side wall of the processing barrel in a penetrating mode. A gear is driven by a toothed plate to intermittently rotate, so that the gear controls a baffle through a special-shaped plate to intermittently seal an atomizing mixing barrel, and a mixed solution in the atomizing mixing barrel intermittently flows into a connecting barrel; the problem that the solution in the atomization mixing cylinder cannot flow completely in the process of flowing into the connecting cylinder at a time is avoided, meanwhile, the content of the mixed solution flowing into the connecting cylinder every time is controlled through the concentration detection controller, and then the concentration of the phthalic dicarboxaldehyde disinfectant can be controlled according to needs; furthermore, the flexibility of preparing the phthalic dicarboxaldehyde disinfectant by the equipment is improved.

This invention relates to a method for preparing a β-cyclodextrin functionalized covalent organic framework composite material. The method involves an aldehyde-imine condensation reaction between the aldehyde groups on 2,3,4-trihydroxybenzaldehyde and p-phthalaldehyde and the amino group on hepta(6-amino-6-deoxy)betacyclodextrin to construct a β-CD-COF layer. This one-step method produces a β-cyclodextrin covalent organic framework composite material that exhibits excellent enrichment capacity for phosphopeptides, facilitating purification and extraction. It also shows promising application prospects in mass spectrometry detection and exosome separation.

A method for measuring the concentration of ortho-phthalaldehyde (OPA) in a sample is provided. The method involves the use of a spectrophotometer to measure the absorbance of OPA at a specific wavelength, and the use of a standard curve to convert the change in absorbance value with temperature (slope) to a concentration value. The method is specific (selective), simple, rapid, and highly accurate, making it suitable for use in a variety of applications, such as the monitoring of OPA concentrations in disinfection / sterilization industrial settings.

The invention relates to an o-phthalaldehyde disinfectant. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.1-1 wt% of o-phthalaldehyde; 10 to 30 weight percent of polybasic acid salt; 0.01 to 0.05 wt% of an antioxidant; 0.005 to 0.05 wt% of a polymerization inhibitor; 0.1 to 0.5 wt% of a slow release agent; and the balance of water. The o-phthalaldehyde disinfectant disclosed by the invention can effectively prevent grey dyeing, is short in sterilization time and is suitable for high-level disinfection and sterilization of medical instruments.

The invention discloses phthalic dicarboxaldehyde concentration detection test paper as well as a preparation method and application thereof, and belongs to the technical field of chemical detection. The preparation method comprises the following steps: S1, dissolving a salt compound formed by sulfite, organic amine and acid into water to obtain a soaking solution; s2, immersing filter paper into the soaking solution, taking out the filter paper after full soaking, and drying the filter paper; and S3, pasting the dried filter paper on a non-absorbent substrate to obtain the phthalic dicarboxaldehyde concentration detection test paper: taking a certain volume of phthalic dicarboxaldehyde solution and dropwise adding the phthalic dicarboxaldehyde solution on the test paper during use, and observing the color change of the test paper after a period of time to judge whether the concentration of the phthalic dicarboxaldehyde solution is in an effective range or not. The method disclosed by the invention is simple, the concentration of the effective components is not easy to change in the drying process and the storage process, and the prepared test paper can be used for rapidly and accurately detecting the concentration of the phthalic dicarboxaldehyde.

The application discloses a synthesis method of o-phthalaldehyde. O-xylene, a halogenated reagent and an organic solvent are mixed, and under ultraviolet light irradiation, a bromination product with different bromination degrees is generated by reaction; water is added into the reaction liquid, and the reaction is continuously carried out; after the reaction is completed, the organic solvent and water are removed by evaporation, and a crude ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product is obtained; the crude product is recrystallized to obtain ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product; and the ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene is hydrolyzed to obtain o-phthalaldehyde. The synthesis method optimizes the bromination and hydrolysis process, and by adding appropriate water in the o-xylene bromination process, the yield of the final product o-phthalaldehyde is improved.

The application discloses a kind of meat freshness rapid test paper, belong to food rapid detection technical field.The test paper is with water absorption filter paper as base material, and is loaded by the reaction color developing system consisting of o-Phthaldehyde, mercapto glycolic acid, sodium acetate buffer and fast blue B salt, can occur specific color reaction with the biological amine (putrescine) generated in the meat spoilage process, and realizes freshness rapid judgment by color ladder change.The detection time of the application is only 3-5 minutes, without large instrument, simple operation, high sensitivity, low cost, wide spectrum, can be used for on-site rapid screening of pork, beef, mutton, frozen shrimp, frozen chicken breast and other various meats, and is widely applicable to raw material acceptance of meat processing enterprises, market supervision law enforcement and cold chain logistics quality monitoring.

The present invention relates to disinfection technology, and particularly to a quality control technology for o-phthalaldehyde disinfectant solution. A rapid detection indicator card impregnation composition for o-phthalaldehyde disinfectant solution, which comprises the following in mass percentages: stabilizer: 1% - 10%; chelating agent: 5% - 20%; neutralizing agent: 0.1% - 2%; chromogenic agent: 0.1% - 20%; chromogenic accelerator: 1% - 4%; the balance is pure water. After impregnating filter paper with the composition and drying it, it is pasted on white plastic paper with double-sided tape and compacted to form the rapid detection indicator card. The indicator card of the present invention has more stable, obvious and clear color development, rapid detection and more reliable results.

The invention discloses a post-column derivatization detection method of ethyl lauroyl arginate, which comprises the following steps: pre-treating food, extracting ethyl lauroyl arginate hydrochloride with an acetonitrile aqueous solution, filtering with an aqueous filter membrane, separating with a high performance liquid chromatography column, taking mercaptan and o-phthalaldehyde as derivatization reagents, and carrying out post-column derivatization detection on ethyl lauroyl arginate under an alkaline condition, so as to obtain the ethyl lauroyl arginate. And carrying out a derivative reaction to generate a fluorescent derivative, carrying out derivative fluorescence detection, and quantitatively determining the content of the ethyl lauroyl arginate hydrochloride. The method has the characteristics of rapidness, high sensitivity and low detection limit. The method is suitable for determination of trace ethyl lauroyl arginate hydrochloride in dairy products, fruit products, meat products, aquatic products, beverages or gum-based candies. And a detection method is provided for the detection of trace ethyl cinnamyl arginate hydrochloride.

The present invention belongs to the field of macromolecular and polymer synthesis. Aiming at the problems that the polymerization reaction of polyphthalaldehyde (POPD) generated by polycondensation of POPD monomer usually needs to be carried out at an ultra-low temperature (≤-40°C), the polymer has poor stability at room temperature and is easy to depolymerize, and the polymer needs to be end-capped after the reaction, the present invention provides a single-component organic Lewis acid-base pair having the structural formula: #imgabs0#n is the carbon chain length, R is any one of hydrogen, methyl, ethyl, butyl, phenyl or substituted phenyl; X is any one of halogen Cl, Br, I, acetate, trifluoroacetate, and succinate; R 1 、R 2 It is one or a combination of hydrogen, alkyl, cycloalkyl, aryl or substituted aryl; Y is a bridged skeleton. The single-component organic Lewis acid-base pair can achieve polymerization of o-phthalaldehyde and epoxy compounds under relatively mild conditions, and the obtained polymer does not need to be end-capped and can be purified for use.

The invention belongs to the field of protein hydrogel materials, and particularly relates to elastin-like and a preparation method and application of elastin-like hydrogel. According to the present invention, the two elastin-like proteins A and B having different amino acid sequences are utilized to form the cross-linked network through the isopeptide bond, such that the mechanical strength of the polymer hydrogel composed of the four-arm polyethylene glycol amine, 4-arm PEG-NH2 and the o-phthalaldehyde modified four-arm polyethylene glycol, 4-arm PEG-OPA can be effectively improved, the adhesion can be improved, and the cross-linked network can be used for the preparation of the polymer hydrogel, such that the cross-linked network can be formed through the cross-linked network, such that the cross-linked network can be used for the preparation of the polymer hydrogel, and the use amount of the polymer hydrogel can be reduced. The obtained elastin-like hydrogel has the advantages of strong wet tissue adhesion capacity, good biocompatibility, injectable use and the like, and is beneficial to application in the biomedical fields of hemostasis, tissue repair and the like.

This invention discloses an amino acid assay kit based on the o-phthalaldehyde (OPA) method, its preparation method, and its application. Belonging to the field of amino acid detection and analysis technology, it is used for rapid and accurate quantitative detection of amino acids in samples. The amino acid assay kit can not only measure the total amino acid content but also analyze specific amino acids and dipeptides such as alanine glutamine, meeting diverse analytical needs. This amino acid assay kit is suitable for batch testing and supports high-throughput laboratory applications. By optimizing the reagent formulation and operating procedures, this invention effectively simplifies the detection steps, improves detection sensitivity and specificity, and fills the gap in the market for OPA-based assay kits. This invention can be widely applied in nutrition, medicine, clinical diagnostics, and drug development, providing a convenient and efficient amino acid analysis tool for life science and medical research.

The invention discloses a method for detecting an impurity E in a granisetron hydrochloride injection by utilizing an HPLC (High Performance Liquid Chromatography) on-line derivatization method, belonging to the technical field of chemical engineering and pharmacy. According to the method, a high performance liquid chromatography method is adopted, an Ultimate AQ-C18 column is used as a chromatographic column, a mixed solution of a 0.1% phosphoric acid solution and acetonitrile is used as a mobile phase, and an o-phthalaldehyde solution is used as a derivatization reagent; quantitative detection of the impurity E in the granisetron hydrochloride injection is realized through specific instrument conditions, solution preparation and measurement recording steps. The method is simple and convenient to operate, strong in specificity, high in sensitivity and accuracy, good in linearity and capable of effectively detecting the quality of the granisetron hydrochloride injection product.

The present application relates to a kind of diacetylene functionalized covalent organic framework material and its preparation method and application, to 4,4',4'',4'''-(pyrene-1,3,6,8-tetrayl) tetraphenylamine, 5,5'- (but-1,3-diethynyl-1,4-diyl) diisophthalaldehyde as building unit, synthesis using Schiff base reaction.The diacetylene functionalized covalent organic framework material of the present application has good chemical stability, and can be used as carrier by metal coordination effect Controllable growth silver nanoparticles to obtain composite material, the composite material in sodium borohydride catalytic 4-nitrophenol reduction reaction has shown excellent catalytic activity and cycle stability, thus has important application potential in the field such as environmental remediation and green chemistry.

The application discloses a method for preparing o-phthalaldehyde from o-xylene. V2O5-TiO2 doped with metal elements is used as a catalyst, o-xylene and an oxygen-containing gas are reacted to obtain a mixed oxidation product containing o-phthalic anhydride, o-phthalic acid and phthalide; the mixed oxidation product is reacted with a reducing agent in a solvent, and o-phthalalcohol is obtained after separation; and the o-phthalalcohol is reacted with an oxidizing agent, and o-phthalaldehyde is obtained after separation. The application avoids the use of corrosive substances such as bromine or chlorine and nitric acid, has low requirements on equipment, is small in environmental pollution, and is high in overall yield of o-phthalaldehyde.

The invention belongs to the technical field of medical carriers, and relates to a hardness-controllable polyethylene glycol nano-drug carrier as well as a preparation method and application thereof. Adsorbing a layer of polyethyleneimine on the surface of the template to obtain a carrier precursor; performing at least one layer assembly on the surface of the carrier precursor; and finally, removing the template. The primary layer assembly process comprises the following steps: firstly, adding multi-arm polyethylene glycol o-phthalaldehyde to carry out a cross-linking reaction, and then adding multi-arm polyethylene glycol amino to carry out a cross-linking reaction; the cross-linking reaction is that the o-phthalaldehyde group reacts with the primary amino group to generate the isoindolinone group. The PEG nano-drug carriers with different hardness can be prepared through a layer-by-layer assembly method, and targeting molecules and / or chemotherapeutic drugs can be introduced in the preparation process; by adjusting the PEG nano-drug carrier with proper hardness and loading the chemotherapeutic drug, the interaction between the nano-drug carrier and a biological interface can be adjusted, so that good tumor treatment is realized.

The invention discloses a pathogenic nucleic acid extraction method based on reverse nucleic acid grabbing, which comprises the following steps: adding a sephadex microsphere solution with the surface modified with functional molecules and a lysis buffer into a bacterial liquid containing pathogenic bacteria, oscillating, inserting filter paper with negative electricity, incubating, taking out the filter paper, centrifuging, and taking out supernatant to obtain purified pathogenic nucleic acid, the functional molecules are o-phthalaldehyde, phenylboronic acid and hydrophobic molecules, the lysate contains lauryl sodium sulfate, disodium hydrogen phosphate and ethylenediamine tetraacetic acid, and the pH value of the lysate is 10.0-10.5. The method has the advantages of simplicity and convenience in operation, high extraction speed, high nucleic acid quality, high nucleic acid extraction rate and the like, and can provide a high-quality nucleic acid sample for molecular diagnosis.

Disclosed are methods for constructing conjugates. An amine-containing component and a thiol-containing component, in comparable mole ratios, react with an ortho-phthalaldehyde in one step, to generate a conjugate bearing a substituted or an unsubstituted 1-thio-isoindole structure in the presence of an additive. The method provides a platform for the efficient and practical constructions of bioactive modular motifs.

The invention discloses a device and a method for detecting the real-time concentration of an o-phthalaldehyde disinfectant. The device comprises a constant-speed liquid dropping device and a self-powered liquid sensor, the self-powered liquid sensor comprises a glass substrate (1), a bottom electrode (2) is arranged on the glass substrate (1), a dielectric layer (3) is arranged on the bottom electrode (2), and a top electrode (4) is arranged on the dielectric layer (3); a sample dropping port of the constant-speed liquid dropping device is arranged above the top electrode (4) and is used for realizing uniform dropping of an o-phthalaldehyde disinfectant and enabling the o-phthalaldehyde disinfectant to flow through the top electrode (4) from top to bottom; the top electrode (4) and the bottom electrode (2) are connected with an oscilloscope through signal pin electrodes, and the output end of the oscilloscope is connected with a machine learning processing module. The method can detect the concentration of the o-phthalaldehyde disinfectant in real time, and has the advantages of high detection speed, accurate detection result, high sensitivity and low cost.

The invention discloses a preparation method of 3, 4, 5, 6-tetrafluorophthalonitrile, and belongs to the technical field of organic intermediates. The preparation method comprises the following steps: reacting 3, 4, 5, 6-tetrafluorophthalic dicarboxaldehyde serving as a raw material with hydroxylamine hydrochloride to generate a dioxime intermediate; the preparation method comprises the following steps: reacting 2, 4, 5, 6-tetrafluorophthalonitrile with 1, 3-benzene disulfonyl chloride to generate a cyclized intermediate, and finally removing 1, 3-benzene disulfonic acid to generate 3, 4, 5, 6-tetrafluorophthalonitrile. According to the method, the design is reasonable, the yield is high, the cyclization intermediate does not need to be purified, the dinitrile product can be obtained through catalysis of a small amount of acid, and a convenient route is provided for high-yield obtaining of high-quality 3, 4, 5, 6-tetrafluorophthalonitrile.

This invention discloses a method for ammonia nitrogen detection. The apparatus used in the detection method includes a flow mechanism and a detection mechanism. One end of the flow mechanism receives an external water sample to be tested, and the other end is connected to the detection mechanism. The two ends of the detection mechanism serve as an inlet and an outlet, respectively, both connected to a liquid flow tube provided in the flow mechanism. The flow mechanism guides the water sample to be tested through the liquid flow tube for cyclic mixing before flowing into the detection mechanism for ammonia nitrogen concentration detection. The ammonia nitrogen detection method proposed in this invention is a flow analysis turbidity correction method for the detection of ammonia nitrogen by the orthophthalaldehyde fluorescence method, and establishes a relationship model between turbidity and ammonia nitrogen concentration. This method can significantly reduce the interference of turbidity on the fluorescence method for ammonia nitrogen detection. The method has a wide applicable turbidity correction range and is suitable for ammonia nitrogen detection correction in complex water samples.