Phthalaldehyde disinfectant

Abstract

The invention relates to an o-phthalaldehyde disinfectant. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.1-1 wt% of o-phthalaldehyde; 10 to 30 weight percent of polybasic acid salt; 0.01 to 0.05 wt% of an antioxidant; 0.005 to 0.05 wt% of a polymerization inhibitor; 0.1 to 0.5 wt% of a slow release agent; and the balance of water. The o-phthalaldehyde disinfectant disclosed by the invention can effectively prevent grey dyeing, is short in sterilization time and is suitable for high-level disinfection and sterilization of medical instruments.

Description

Technical Field

[0001] The present invention relates to a disinfectant for medical devices, and particularly to an ortho-phthalaldehyde disinfectant solution. Background Art

[0002] Ortho-phthalalehyde (OPA) is an important intermediate in pharmaceutical and chemical industries. It was mainly used for amine alkaloids, fluorescence histamine assay reagents and medical tests before. In the 1990s in the United States, ortho-phthalaldehyde was developed into a new type of chemical disinfectant. Its bactericidal effect on microorganisms mainly depends on the aldehyde group, which acts on the hydroxyl, carboxyl and amino groups of the bacterial cell protein, alkylates them, causes protein coagulation and results in bacterial death. Ortho-phthalaldehyde has the characteristics of broad-spectrum, high efficiency, low toxicity, little corrosion to metals, little influence by organic matters and good stability. Clinically, ortho-phthalaldehyde is mainly used for high-level disinfection of medical devices. Because of its low volatility and no pungent smell, it is quite popular among clinical staff. However, its disadvantages are also obvious. One is that the sterilization time is long, and it takes up to 14 hours to achieve the sterilization effect. The other is that the phenomenon of gray staining is common, which often causes grayish-green spots to appear in the endoscopic disinfection tank and perfusion pipeline. If it accidentally splashes on the skin or clothes of the staff, it will also leave gray marks and is difficult to clean. Summary of the Invention

[0003] The present invention aims to provide an ortho-phthalaldehyde disinfectant solution, which shortens the sterilization time of the ortho-phthalaldehyde disinfectant solution and effectively prevents the phenomenon of gray staining through scientific formula combination.

[0004] According to an embodiment of the present invention, an ortho-phthalaldehyde disinfectant solution provided by the present invention has the following components and their weight percentages:

[0005] Ortho-phthalaldehyde 0.1-1 wt%;

[0006] Polybasic acid salt 10-30 wt%;

[0007] Antioxidant 0.01-0.05 wt%;

[0008] Polymerization inhibitor 0.005-0.05 wt%;

[0009] Sustained-release agent 0.1-0.5 wt%;

[0010] The balance is water.

[0011] In the ortho-phthalaldehyde disinfectant solution of the present invention, the polybasic acid salt is sodium citrate, sodium malate or sodium succinate.

[0012] In the ortho-phthalaldehyde disinfectant solution of the present invention, the antioxidant is vitamin E polyethylene glycol succinate or vitamin C phosphate.

[0013] In the phthalaldehyde disinfectant solution of the present invention, the inhibitor is hydroquinone or tert-butylcatechol.

[0014] In the phthalaldehyde disinfectant solution of the present invention, the slow-release agent is sodium benzoate or sodium polyacrylate.

[0015] The preparation method of the phthalaldehyde disinfectant solution of the present invention is as follows: according to the components and contents, add phthalaldehyde into water and stir to dissolve; then add antioxidant, inhibitor, slow-release agent, and polybasic acid salt in sequence and stir to dissolve, thus obtaining the phthalaldehyde disinfectant solution.

[0016] The characteristics of the present invention are that phthalaldehyde is used as the main bactericidal component, combined with polybasic acid salt, as well as antioxidant, inhibitor, and slow-release agent. Through scientific proportioning, the sterilization performance of the phthalaldehyde disinfectant solution is improved, and the phenomenon of gray staining is effectively prevented. High-concentration polybasic acid plays a key role in improving the sterilization performance of the phthalaldehyde disinfectant solution and preventing the gray staining phenomenon. High-concentration polybasic acid has a significant impact on the living environment of microorganisms. When used in combination with phthalaldehyde, the sterilization time is greatly shortened. High-concentration polybasic acid also has a complexing and scale-removing effect, effectively preventing the attachment of the phthalaldehyde conjugate on instruments, clothes, and skin, preventing the gray staining phenomenon, and being conducive to cleaning. The antioxidant can prevent the aldehyde group from being oxidized, and the inhibitor can prevent the aldehyde group from polymerizing. When used together, the stability of phthalaldehyde can be significantly improved. The slow-release agent can reduce the corrosion of phthalaldehyde to metals, enabling the phthalaldehyde disinfectant solution to have basically no corrosion to metals such as stainless steel, carbon steel, copper, and aluminum. Specific embodiments

[0017] The present invention will be further described below in conjunction with specific embodiments. These embodiments should be understood as only for illustrating the present invention and not for limiting the protection scope of the present invention. After reading the content recorded in the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

[0018] Example 1

[0019] Add 5 g of phthalaldehyde into 789.65 g of water and stir to dissolve; then add 0.3 g of vitamin E polyethylene glycol succinate, 0.05 g of hydroquinone, 5 g of sodium benzoate, and 200 g of sodium citrate in sequence and stir to dissolve, thus obtaining the phthalaldehyde disinfectant solution.

[0020] Example 2

[0021] Add 3 g of o-phthalaldehyde to 693.85 g of water and stir to dissolve. Then add 0.1 g of vitamin C phosphate, 0.05 g of hydroquinone, 3 g of sodium benzoate, and 300 g of sodium succinate in sequence and stir to dissolve to obtain the o-phthalaldehyde disinfectant solution.

[0022] Example 3

[0023] Add 6.5 g of o-phthalaldehyde to 837.75 g of water and stir to dissolve. Then add 0.5 g of vitamin E polyethylene glycol succinate, 0.25 g of tert-butylcatechol, 5 g of sodium polyacrylate, and 150 g of sodium malate in sequence and stir to dissolve to obtain the o-phthalaldehyde disinfectant solution.

[0024] Example 4

[0025] Add 2 g of o-phthalaldehyde to 796.25 g of water and stir to dissolve. Then add 0.15 g of vitamin C phosphate, 0.1 g of tert-butylcatechol, 1.5 g of sodium polyacrylate, and 200 g of sodium succinate in sequence and stir to dissolve to obtain the o-phthalaldehyde disinfectant solution.

[0026] Example 5

[0027] Add 8 g of o-phthalaldehyde to 888.1 g of water and stir to dissolve. Then add 0.4 g of vitamin C phosphate, 0.5 g of tert-butylcatechol, 3 g of sodium polyacrylate, and 100 g of sodium malate in sequence and stir to dissolve to obtain the o-phthalaldehyde disinfectant solution.

[0028] Example 6

[0029] Add 1.5 g of o-phthalaldehyde to 694.55 g of water and stir to dissolve. Then add 0.3 g of vitamin E polyethylene glycol succinate, 0.15 g of hydroquinone, 3.5 g of sodium benzoate, and 300 g of sodium citrate in sequence and stir to dissolve to obtain the o-phthalaldehyde disinfectant solution.

[0030] Test Example

[0031] Respectively take the o-phthalaldehyde disinfectant solutions prepared in Examples 1-6 and conduct an accelerated stability test according to the method in the "Disinfection Technical Specification" (2002 Edition) of the Ministry of Health of the People's Republic of China. The results of the accelerated stability test show that after the o-phthalaldehyde disinfectant solutions prepared in Examples 1-6 are placed at 37 °C for 90 days, the properties of the disinfectant solutions have no obvious changes, and the decline rate of the o-phthalaldehyde content is <10%, indicating that the product's valid period can reach 2 years.

[0032] According to the method in the "Disinfection Technical Specification" (2002 edition) of the Ministry of Health of the People's Republic of China, the metal corrosion test was carried out. The results of the metal corrosion test showed that the o-phthalaldehyde disinfectant solution prepared in Examples 1-6 had basically no corrosion on metals such as stainless steel, carbon steel, copper, and aluminum.

[0033] According to the sterilization test method in the "Disinfection Technical Specification" (2002 edition) of the Ministry of Health of the People's Republic of China, the sterilization test was carried out. The results of the sterilization test showed that the o-phthalaldehyde disinfectant solution prepared in Examples 1-6 could achieve the sterilization effect after acting for 4 hours.

[0034] The o-phthalaldehyde disinfectant solution prepared in each of Examples 1-6 was taken separately for the gray staining degree test. A white pure cotton cloth with a size of about 20 cm * 20 cm was soaked in a 0.3% bovine serum albumin solution for 5 minutes, taken out, and dried at 45 °C for standby. Under room temperature conditions, the above-prepared white cotton cloth was soaked in the o-phthalaldehyde disinfectant solution prepared in Examples 1-6 for 5 minutes, taken out, and the gray staining degree on the white cotton cloth was visually observed. After natural drying, the gray staining degree on the white cotton cloth was visually observed again. A synchronous control test was carried out with a common o-phthalaldehyde disinfectant solution on the market. The results of the gray staining degree test showed that there were no obvious gray traces on the white cotton cloth soaked in the o-phthalaldehyde disinfectant solution prepared in Examples 1-6, and there were also no obvious gray traces on the white cotton cloth after drying. The white cotton cloth soaked in the common o-phthalaldehyde disinfectant solution on the market changed color significantly, showing a large area of grayish brown, and the grayish brown residue on the cotton cloth did not fade after drying.

[0035] In summary, the o-phthalaldehyde disinfectant solution provided by the present invention has stable properties and basically no corrosion on metals. Compared with the common o-phthalaldehyde disinfectant solution on the market, the sterilization time is greatly shortened to 4 hours, and at the same time, there is no obvious gray staining phenomenon on instruments, clothes, etc., and it has good popularization and application value.

Claims

1. A phthalaldehyde disinfectant, characterized in that: Its components and their weight percentages are as follows: Phthalic acid 0.1-1wt%; Polyacid salt 10-30wt%; Antioxidant 0.01-0.05wt%; Inhibitor 0.005-0.05wt%; Sustained release agent 0.1-0.5wt%; The balance is water.

2. The o-phthalaldehyde disinfectant according to claim 1, characterized in that The polyacid salt is sodium citrate, sodium malate or sodium succinate.

3. The o-phthalaldehyde disinfectant according to claim 1, characterized in that The antioxidant is vitamin E polyethylene glycol succinate or vitamin C phosphate.

4. The o-phthalaldehyde disinfectant according to claim 1, characterized in that: The polymerization inhibitor is hydroquinone or tert-butylcatechol.

5. The o-phthalaldehyde disinfectant according to claim 1, characterized in that: The sustained-release agent is sodium benzoate or sodium polyacrylate.

6. The o-phthalaldehyde disinfectant according to claim 1, wherein the preparation method is as follows: according to the components and contents, o-phthalaldehyde is added into water and stirred to dissolve; an antioxidant, an inhibitor, a sustained-release agent and a polyacid salt are added in sequence and stirred to dissolve, thereby obtaining the o-phthalaldehyde disinfectant.