218 results about "Hormones levels" patented technology

The invention provides a strain of lactobacillus plantarum YS-AG23 with high antioxidant activity, and a rhizoma polygonati and radix angelicae sinensis fermented product obtained by fermenting rhizoma polygonati and radix angelicae sinensis with the strain of lactobacillus plantarum YS-AG23. In a D-galactose induced premature ovarian failure mouse model, the fermentation product can regulate up the levels of antioxidant and stress protection genes SOD2 and HO-1 and an anti-aging gene SIRT1 by regulating down the expression of a key gene AGER of an inflammation and oxidative stress pathway, so that the oxidative stress and inflammatory response of model mouse ovarian tissues are remarkably reduced; meanwhile, the serum hormone level can be specifically adjusted, the serum estradiol (E2) level can be increased, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels can be reduced to be close to the normal range, the expression of anti-mullerian hormone (AMH) and hormone regulatory gene LHR of ovarian reserve markers can be up-regulated, the proliferative activity and estrogen secretion function of follicular granulosa cells can be improved, and the effect of preventing ovarian reserve is achieved. The wet weight of atrophic uterus and ovary of the model mouse is remarkably increased, uterine and ovary atrophy is effectively reversed, and the ovarian reserve function of the D-galactose induced premature ovarian failure model mouse is recovered. Besides, in an H2O2-induced human dermal fibroblast aging model, the yeast can improve the activity of aging cells in a concentration-dependent manner and reduce the level of reactive oxygen species (ROS) in the cells; in addition, by up-regulating the expression of a collagen synthesis key gene COL1A1 and down-regulating the expression of a cell senescence marker gene p16, skin cell senescence caused by oxidative stress can be effectively improved. In conclusion, the polygonatum sibiricum and angelica sinensis leavening can synchronously improve premature ovarian failure and skin cell senescence caused by oxidative stress by accurately regulating and controlling oxidative stress, inflammatory response and tissue function related genes, and has wide application potential.

The invention relates to the technical field of microorganisms, and provides Witzia ciliaris KY009 (preservation number is CGMCC (China General Microbiological Culture Collection Center) NO. 33480) and Clostridium butyricum KY002 (preservation number is CGMCC NO. 33478), and the two strains are separated from an excrement sample. Experiments prove that the two strains can obviously improve the sperm quality and quantity, regulate the sex hormone level, improve the intestinal inflammation symptom and regulate the expression of related inflammatory factors. The invention also provides a composition containing the two strains, wherein the composition comprises a food composition, a pharmaceutical composition, a health-care product composition, a functional microbial agent and the like. The compositions are useful for improving reproductive health, modulating sex hormone levels, treating intestinal inflammation and promoting mucosal repair, and alleviating metabolic and immune related diseases. The strain and the composition provided by the invention have wide application prospects in the fields of medicines, foods and health-care products.

The invention discloses an artificial intelligence-driven polycystic ovarian syndrome drug target screening method, which comprises the following steps: S1, collecting genome data and hormone level data from the body of a patient, and constructing a patient individualized data set; s2, carrying out denoising processing, missing value filling and standardization on the acquired individual data set of the patient; s3, inputting the standardized individual data set of the patient into a multi-layer neural network model; s4, training the dynamic gene-hormone interaction network model by adopting the training set data; s5, screening out dual regulation and control drug targets highly related to the PCOS pathological mechanism; s6, performing optimization through historical treatment data of the patient and target treatment effect feedback; and S7, outputting the dual regulation and control drug target list in a report form. According to the invention, the efficiency and accuracy of drug target screening are significantly improved.

The invention belongs to the technical field of biological medicines, and discloses application of beta-elemonic acid or derivatives thereof or pharmaceutically acceptable salts thereof in preparation of medicines for preventing and / or treating polycystic ovarian syndrome (PCOS). The beta-elemonic acid is screened from a medicinal and edible library, and experiments prove that the beta-elemonic acid can remarkably improve the PCOS ovarian form and the number of mature follicles, normalize the disordered estrus cycle, remarkably improve the serum hormone level and further remarkably improve the sugar tolerance, insulin tolerance and weight of PCOS. The beta-elemonic acid disclosed by the invention is a compound based on homology of medicine and food, can be used as a medicine as well as a natural ingredient of food, is relatively low in toxicity, ensures the safety after long-term use, is relatively low in safety evaluation cost of a relatively brand-new synthetic compound, and can be applied to development and preparation of a medicine or a lead compound thereof for preventing and / or treating PCOS, or a health care product.

The invention discloses a fructus lycii pigment composition for treating benign prostatic hyperplasia and application. The fructus lycii pigment composition comprises lycium barbarum red, zeaxanthine, xanthophyll and beta-carotene. The fructus lycii pigment composition provided by the invention can effectively inhibit prostate stromal cell proliferation, inhibit prostate tissue hyperplasia in vivo, improve the pathological morphology of prostate tissue, regulate the androgen level, inhibit inflammatory response and relieve oxidative damage. The traditional Chinese medicine is applied to clinical treatment of prostatic hyperplasia and has the advantages of remarkable curative effect and low toxic and side effects.

The invention discloses a sleep assisting system and method based on endocrine detection, and relates to the technical field of medical health information.The sleep assisting system comprises an acquisition module used for acquiring brain wave signals and electrocardiogram data of a user and obtaining cortisol hormone level data through a wearable sensor; the model building module is used for building a human body circadian rhythm cycle model according to the cortisol hormone level data and the brain wave signals acquired by the acquisition module; the sleep state evaluation module is used for matching the human body circadian rhythm cycle model with the electrocardiogram data acquired by the acquisition module to obtain a sleep state evaluation result; the light adjusting module is used for adjusting indoor light according to the evaluation result of the sleep state evaluation module, guiding melatonin secretion and adjusting the sleep rhythm of the user. Through collaborative analysis of the multi-dimensional physiological signals, the circadian rhythm and sleep state of the user can be evaluated more accurately, and then sleep quality regulation and control are improved.

The invention relates to the technical field of medical care, in particular to a polycystic ovarian syndrome detection method based on multi-dimensional biomarker analysis, which comprises the following steps: S1, patient data acquisition: acquiring multi-modal health data of a patient; s2, integrating and standardizing the biomarker data: integrating the health data of different dimensions; s3, performing pathogenesis inference based on a hormone and metabolism coupling model: performing coupling analysis on the hormone level and metabolism data of the patient, and revealing a mutual influence mechanism of the hormone level and the metabolism data in the polycystic ovarian syndrome; s4, risk score calculation: calculating the risk score of the polycystic ovarian syndrome of the patient; and S5, diagnosis feedback and dynamic optimization: dynamically adjusting the detection scheme. According to the method, the accuracy and the flexibility of the diagnosis and treatment scheme are improved, all-around data support is provided for doctors, and personalized and dynamic long-term health management and optimization of the treatment scheme are assisted.

The invention belongs to the technical field of medical supplies, and particularly relates to a composition for improving perimenopausal symptoms. The feed consists of the following components in parts by weight: 400-700 parts of protein substances, 30-50 parts of fat substances, 120-170 parts of carbohydrate substances, 40-90 parts of dietary fiber substances, 30-80 parts of medicinal and edible substances, 2-6 parts of compound trace minerals, 50-95 parts of compound macro minerals, 3-5 parts of compound vitamins and 5-10 parts of blueberry powder. Wherein the protein substance is composed of whey protein, soybean protein and collagen peptide in a mass ratio of (7-12): (6.1-8.5): 1. According to the composition disclosed by the invention, the perimenopausal symptoms such as hectic fever, insomnia, osteoporosis, decrease of estrogen level, uterine atrophy and the like can be remarkably improved by accurately controlling the proportion of soybean protein and collagen peptide in protein.

The invention relates to the technical field of medicine application, and discloses a medicine composition for preventing or treating reproductive dysfunction of elderly women and application of the medicine composition. The invention provides a new therapeutic drug and means for prevention and treatment of reproductive dysfunction of elderly women. By constructing an animal model of reproductive dysfunction of the elderly women and taking the ovulation number of animals, hormone level related to reproduction, pregnancy rate and progeny development condition as detection indexes, the pharmacodynamic effect and safety of the pharmaceutical composition and the influence of the pharmaceutical composition on progeny development quality and genetic variability are evaluated for the first time; the effectiveness and safety of the pharmaceutical composition for treating reproductive dysfunction of elderly women are fully proved.

The present invention relates to the technical fields of molecular biology, virology, immunology and medicine, and in particular to a castration vaccine having engineered ferritin and GnRH expressed in tandem, and a use. In the present invention, the engineered ferritin and different quantities of GnRH are linked in tandem and then recombined, so as to construct a GnRH-ferritin nanoparticle castration vaccine. The vaccine is used for castration of animals. Experimental results show that the GnRH and mutant ferritin recombined vaccine has a significantly enhanced immune effect and can significantly reduce testosterone levels and testicular weight, and compared with other combination methods, the nanoparticle castration vaccine having four GnRHs and the mutant ferritin linked in tandem has higher expression, stronger immunogenicity, faster immune response, and significant advantages in effect, and can be widely applied in the technical field of castration of animals.

The invention relates to the technical field of defect detection, in particular to a thyroid ultrasonic auxiliary scanning method and system, and the method comprises the following steps: obtaining a pixel gray value, local contrast and edge sharpness of a thyroid ultrasonic image, calculating a pixel gradient change rate, and screening a thyroid gland boundary region according to the gradient amplitude change rate. According to the method, the pixel gradient change rate is calculated, the boundary region is screened, the gland recognition accuracy is enhanced, noise interference is reduced, the boundary segmentation is optimized in combination with the multi-scale gradient change rate and the edge strength, the error recognition probability is reduced, the gradient difference weight matrix is constructed, and the boundary is adjusted based on the gray level uniformity, so that the segmentation is more in line with the tissue form; the low-contrast lesion detection capability is improved in combination with gray shift, gradient direction distribution and morphological parameters, the classification accuracy is improved through matching of the morphological change rate and global features, diagnosis support is optimized in combination with the gland volume, the hormone level and the lesion morphological ratio, and the credibility of personalized diagnosis is improved.

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating ovarian dysfunction, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 8-10 parts of American ginseng, 2-4 parts of pseudo-ginseng, 55-65 parts of kudzuvine root, 42-48 parts of coptis chinensis, 42-48 parts of scutellaria baicalensis, 14-16 parts of stiff silkworm, 14-16 parts of rhizoma zingiberis, 42-48 parts of bitter gourd and 55-65 parts of rhizoma anemarrhenae. The traditional Chinese medicine composition has the effects of increasing the number of follicles and corpus luteum, restoring the duration of an estrus cycle and restoring the levels of serum hormones and sex hormone receptors. The traditional Chinese medicine composition provided by the invention provides a new means for preventing and treating ovarian dysfunction.

Disclosed herein are compositions and methods for treating diabetes, wherein the compositions comprise a GLP-1 agonist. The disclosed compositions are also effective in reducing body weight and improving triglyceride and cholesterol levels. Disclosed herein are methods for treating type 2 diabetes mellitus in a subject, for reducing A1C in a subject, for reducing body mass in a subject, and for modulating a hypoglycemic hormone level in a subject.

The invention relates to the technical field of health management systems, and provides a pituitary hormone level monitoring-based health management system, which comprises a multi-source data acquisition terminal, a hormone analysis terminal, an intelligent decision center terminal and a visual interaction terminal, the multi-source data acquisition terminal is used for regularly acquiring a blood sample and work and rest rule information of a user; the hormone analysis terminal is used for measuring the hormone concentration of a specified hormone type in the blood sample and generating hormone time sequence information; the specified hormone type is preset by an administrator or is set according to health management requirements; the intelligent decision center terminal is used for performing individual health state assessment of the user according to the hormone time sequence information and the work and rest rule information, and generating health state assessment information and health strategy suggestions; and the visual interaction terminal is used for displaying the health state evaluation information and the health strategy suggestions. The method has the effect of improving the accuracy of health management.

The present invention belongs to the technical field of medicine and food homologous compositions, and discloses a composition for enhancing exercise endurance and its applications. It is found that the composition has the following effects: (1) After 30 minutes of intervention with a high dose of the composition, exercise endurance can be significantly enhanced, and it can affect exercise endurance by regulating the levels of hormones such as testosterone and cortisol. (2) Intervention with the composition for 14 days can significantly prolong the swimming time to exhaustion under negative gravity in mice, reduce the accumulation of harmful metabolites, thereby increasing the body's energy metabolism and reducing the degree of fatigue of the body. (3) Intervention with a high dose of the composition for 28 days can significantly increase exercise endurance, and by increasing the muscle glycogen reserve and reducing the accumulation of harmful metabolites such as urea nitrogen and lactic acid, the effect of improving exercise endurance is achieved.

The present application relates to the field of biological medicine and modernization of traditional Chinese medicine, and particularly relates to a therapeutic target, an inhibitor and a traditional Chinese medicine composition for treating ovarian hypofunction caused by oxidative stress and application thereof. The present application first determines SRC tyrosine kinase as a key drug target for preventing and treating the disease. The application of the SRC tyrosine kinase inhibitor (such as secaitinib) in preparing related drugs is provided, which can alleviate the damage of ovarian granulosa cells by inhibiting the SRC activity, down-regulating the expression of antioxidant enzyme related genes and reducing the level of active oxygen. Meanwhile, the present application provides a traditional Chinese medicine composition composed of mulberry, kudzu root, tuckahoe and medlar. The composition can improve the hormone level, enhance the antioxidant capacity, improve the ovarian function and fertility by inhibiting the SRC tyrosine kinase activity and the SRC-RAF1-MEK-ERK signal pathway. The present application provides a new solution for the targeted treatment of ovarian hypofunction and the modernization of traditional Chinese medicine.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to Kunxinning and a preparation method and application thereof. The effective components of the Kunxingning disclosed by the invention are artemisinin and artemisinin. Animal experiments prove that kunxingning can improve the early-onset ovarian insufficiency toxicity state of SD rats caused by tripterygium glycosides, reduce ovarian granular cell apoptosis, improve the ovarian pathological state, promote follicular development, restore the serum sex hormone level to be normal to a certain extent, improve the state of proportion imbalance of Th17 / Treg immune cells, and improve the early-onset ovarian insufficiency toxicity of the SD rats. And the mood cycle of the rats is recovered to a certain extent. Meanwhile, the physiological activity of the tripterygium glycosides composition obtained by compounding the kunxingning and the TG is equivalent to that of the TG.

The invention relates to an application of a DIO1 gene in a liver in controlling the body color of a turbot, and belongs to the field of molecular biology, and the application method is as follows: the turbot with golden body color is obtained by overexpressing the DIO1 gene in the liver of the turbot; the amino acid sequence of the protein coded by the DIO1 gene is as shown in SEQ ID NO. 1. The invention discovers that the gene expression level change in the liver can cause the change of the blood hormone level by influencing the thyroid hormone pathway in the turbot for the first time, thereby influencing the color formation of the skin; therefore, the formation of the target body color of the scophthalmus maximus can be controlled by controlling the gene expression level, so that the market value of the scophthalmus maximus is improved.

The invention discloses a chemiluminescence immunoassay method and kit for detecting progestational hormone of pandas, and belongs to the technical field of biological detection. The specific process comprises the following steps: by taking goat anti-mouse IgG as a coating antibody, enabling a progestational hormone standard substance or a to-be-detected sample and horse radish peroxidase labeled progestational hormone to compete with a limited amount of progestational hormone antibodies together; after incubation and washing, a chemiluminescent substrate is added, and quantitative analysis of the progestational hormone in the panda urine or excrement is realized by detecting the intensity of a luminescent signal according to a standard curve. The invention provides a novel chemiluminescence immunoassay method, the sensitivity of the chemiluminescence immunoassay method is far higher than that of a traditional ELISA method (the lowest detection line can reach 31.25 pg / mL), the operation is simple and convenient, the detection is rapid, and the urgent demand on rapid and accurate determination of the hormone level in panda pregnancy monitoring and reproduction management can be met.

An Artificial Intelligence (AI) system trained by a plurality of training data. The AI system is trained by relationships between a time to final menstrual period and ratios between follicle-stimulating hormone levels and estradiol levels, anti-mullerian hormone, race, cholesterol levels, and a presence of one or more contraceptives. The AI system is configured to accept data from only one sample from a user as input and generate a prediction of a time to final menstrual period for the user as output.

The invention discloses a synergistic anti-oxidation urolithin A composition and application thereof in improving the ovarian function direction, and relates to the technical field of biological medicine, and the active ingredients of the composition comprise 10-100 parts of urolithin A and 6-40 parts of coenzyme Q10. According to the composition disclosed by the invention, the used raw materials are food-grade raw materials such as urolithin A and coenzyme Q10, and the urolithin A and the coenzyme Q10 are matched within a certain range, so that a good synergistic interaction effect can be achieved, and the composition has a good antioxidant effect; meanwhile, the composition also has the effects of effectively improving the ovarian reserve function, regulating the hormone level, improving menstruation, skin, emotion, sleep and the like at a low dosage level, and is effective and safe.

The present application relates to a kind of pituitary adenoma simulation teaching method, one aspect, in the case of unified time axis, with the volume of pituitary adenoma as the basis, the hormone level change of corresponding hormone species and visual change condition are associated, can clearly know the curve and numerical value of GH, PRL, ACTH, cortisol and other key hormones, the condition of real-time change with tumor state change, and the real-time synchronization of visual field change and the increase and decrease of tumor size, strengthen the understanding of "space-occupied effect-dysfunction" correlation of the trainee, and the degree of oppression of pituitary adenoma to surrounding tissue is quantified by pressure sensor, the compression phenomenon of pituitary adenoma volume change is directly reflected;Another aspect, for a large number of hormone species data, through the preset data ROI search algorithm, the position of data weak fluctuation can be accurately found, and the corresponding volume change moment of pituitary adenoma helps trainee to locate quickly key time point, improves learning efficiency.

The invention discloses an extract for promoting health and application thereof, and belongs to the technical field of medical and edible dual-purpose and traditional Chinese medicine health care, and the extract is a special extract obtained from beautiful millettia roots. The beautiful millettia root extract exerts new activity for promoting female health through a new mechanism, and the clinical effect is obviously improved. Experimental research proves that the extract promotes self-renewal of female germline stem cells and directional differentiation of the female germline stem cells into oocytes by promoting expression of Notch1, HES1 and HES5 in a Notch signal channel and regulates the female progestational hormone level, and shows the effects of promoting and recovering development of a second sexual character and preventing symptoms of polycystic ovarian syndrome on ovarian development disorder, and has a good application prospect. The radix millettiae speciosae extract is capable of promoting female physical development and maturation, delaying premature ovarian failure, relieving female depression and anxiety states and keeping female health, belongs to a new target and new mechanism, and makes up the mechanism blank of the radix millettiae speciosae extract in the aspect of keeping female health. The application has innovativeness.

The application relates to the field of biotechnology, and particularly relates to an application of Bacteroides ovatus in ovarian aging; the application comprises: taking low-abundance Bacteroides ovatus as a biomarker of ovarian aging; the application comprises using Bacteroides ovatus in a medicine for delaying ovarian aging; the application further comprises using a fermentation product of Bacteroides ovatus in the medicine for delaying ovarian aging; it is found through experiments that there is a significant difference in Bacteroides ovatus in mice with different degrees of ovarian aging, and it is found through subsequent experiments that Bacteroides ovatus has the effects of significantly increasing the number of oocytes, up-regulating anti-Mullerian hormone, up-regulating the level of estradiol and down-regulating the level of follicle-stimulating hormone, which indicates that Bacteroides ovatus can be used in the medicine for delaying ovarian aging.

The invention provides application of rosa roxburghii tratt fruit extract in preparation of drugs or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. The invention belongs to the technical field of biological medicines, and provides application of a roxburgh rose extract in preparation of medicines or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. Animal experiments prove that the rosa roxburghii tratt extract can effectively improve mouse prostate fibrosis and bladder urinary retention caused by high fat diet and relieve lower urinary tract symptoms by regulating lipid metabolism, resisting inflammation, resisting oxidative stress, regulating sex hormone level and inhibiting a TGF-beta / Smad signal channel.

The invention discloses a traditional Chinese medicine composition for treating hypoovarian reserve function. The traditional Chinese medicine composition comprises the following raw material medicines: 10-30 parts of vinegar tortoise shell, 10-15 parts of prepared rehmannia root, 6-20 parts of salt-processed semen cuscutae, 9-15 parts of wine-processed rhizoma polygonati, 10-30 parts of radix puerariae, 9-15 parts of polygonum cuspidatum, 6-20 parts of acanthopanax, 5-15 parts of salvia miltiorrhiza, 6-10 parts of roasted herba epimedii and 3-10 parts of pericarpium citri reticulatae. The invention further discloses application of the traditional Chinese medicine composition in preparation of a medicine for treating ovarian reserve hypofunction. The traditional Chinese medicine composition has the effects of improving the ovarian function and the sex hormone level, increasing the AFC quantity, adjusting the ovarian blood flow state, improving the menstrual condition, the traditional Chinese medicine syndrome and the anxiety level of a patient and improving the clinical pregnancy rate, and is safe and reliable.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of medicines for preventing and treating hyperplasia of mammary glands. Research finds that the traditional Chinese medicine composition prepared from rhizoma arisaematis, radix aconiti, clove, cinnamon, radix angelicae, asarum, ligusticum wallichii, cynanchum paniculatum, frankincense, myrrh, camphor and borneol can obviously reduce the diameter, height and uterine coefficient of nipples of rats with hyperplasia of mammary glands, improve the lesion state of mammary glands, and can obviously improve the levels of sex hormones E2, P, LH and FSH of serum, which indicates that the traditional Chinese medicine composition can be used for treating hyperplasia of mammary glands. The traditional Chinese medicine composition can effectively improve the sex hormone level and the breast lesion state, and has a good treatment effect on rat mammary gland hyperplasia induced by estrogen and progesterone.

The invention discloses application of exosome-like nanoparticles derived from fructus lycii to preparation of a medicine for preventing or treating oligospermia and / or asthenospermia. Sterile, stable and high-purity fructus lycii exosome-like nanoparticles (LBELNs) are obtained by adopting a differential centrifugation-suction filtration-ultra-high-speed centrifugation method, the physiological efficacy of the LBELNs is researched, and it is found that the LBELNs can significantly improve the oligoasthenospermia disease activity index of male mice induced by cyclophosphamide (CTX); the sperm quantity is obviously increased, the sperm malformation is improved, the sperm motility is improved, and the sex hormone level is recovered. The LBELNs can effectively relieve spermatogenic dysfunction of testicular tissues, the sperm differentiation and formation process is obviously improved, the total number of sperms is increased, and the treatment effect is more obvious along with increase of the dosage of the LBELNs. The invention has potential in preparation of drugs for preventing or treating oligoasthenospermia, and provides a new strategy and treatment method for treating oligoasthenospermia.

The invention discloses a protein FDX1 related to remission of reproductive injury as well as a coding gene and application thereof. The invention provides a nucleotide sequence for remission of reproductive injury, wherein the nucleotide sequence is shown as SEQ ID NO. 1. By transfecting the FDX1 gene, the level of glutathione (GSH) in human ovarian granulosa cells is remarkably improved, the resistance of the granulosa cells to oxidative stress is enhanced, oxidative damage caused by BDE-209 is relieved, and reproductive damage is relieved; the transfection of FDX1 can significantly regulate the secretion of AMH, E2, INHB and PROG in granular cells, help to recover the normal state of hormone level, maintain the balance of reproductive endocrine, and relieve reproductive injury; the FDX1 lentivirus sequence disclosed by the invention is a promising drug with clinical application prospect and targeting granular cell function integrity, and has important value for evaluation and treatment of reproductive injury.

This invention discloses an AI-based personalized dynamic embryo culture system, belonging to the field of embryo culture technology. The system adopts a modular architecture, including a core control module, at least one independent culture chamber module, an AI analysis module, and a dynamic regulation module. By employing microfluidic chip technology and an integrated microsensor array, this invention achieves high-precision real-time monitoring of embryo morphology images and physiological parameters of the culture medium. Combined with multimodal data fusion analysis using the AI ​​analysis module, it significantly improves the accuracy and reliability of embryo developmental potential assessment, thereby contributing to increased rates of high-quality embryos and clinical pregnancy success. Furthermore, this invention, through a built-in personalized protocol generation unit, can dynamically generate and execute personalized culture protocols based on the patient's age, ovarian function indicators, and basal hormone levels, while utilizing the dynamic regulation module to simulate the uterine diurnal rhythm for temperature fluctuation control.