86 results about "Hormones levels" patented technology

The present application relates to the field of biological medicine and modernization of traditional Chinese medicine, and particularly relates to a therapeutic target, an inhibitor and a traditional Chinese medicine composition for treating ovarian hypofunction caused by oxidative stress and application thereof. The present application first determines SRC tyrosine kinase as a key drug target for preventing and treating the disease. The application of the SRC tyrosine kinase inhibitor (such as secaitinib) in preparing related drugs is provided, which can alleviate the damage of ovarian granulosa cells by inhibiting the SRC activity, down-regulating the expression of antioxidant enzyme related genes and reducing the level of active oxygen. Meanwhile, the present application provides a traditional Chinese medicine composition composed of mulberry, kudzu root, tuckahoe and medlar. The composition can improve the hormone level, enhance the antioxidant capacity, improve the ovarian function and fertility by inhibiting the SRC tyrosine kinase activity and the SRC-RAF1-MEK-ERK signal pathway. The present application provides a new solution for the targeted treatment of ovarian hypofunction and the modernization of traditional Chinese medicine.

The invention relates to an application of a DIO1 gene in a liver in controlling the body color of a turbot, and belongs to the field of molecular biology, and the application method is as follows: the turbot with golden body color is obtained by overexpressing the DIO1 gene in the liver of the turbot; the amino acid sequence of the protein coded by the DIO1 gene is as shown in SEQ ID NO. 1. The invention discovers that the gene expression level change in the liver can cause the change of the blood hormone level by influencing the thyroid hormone pathway in the turbot for the first time, thereby influencing the color formation of the skin; therefore, the formation of the target body color of the scophthalmus maximus can be controlled by controlling the gene expression level, so that the market value of the scophthalmus maximus is improved.

The invention discloses a chemiluminescence immunoassay method and kit for detecting progestational hormone of pandas, and belongs to the technical field of biological detection. The specific process comprises the following steps: by taking goat anti-mouse IgG as a coating antibody, enabling a progestational hormone standard substance or a to-be-detected sample and horse radish peroxidase labeled progestational hormone to compete with a limited amount of progestational hormone antibodies together; after incubation and washing, a chemiluminescent substrate is added, and quantitative analysis of the progestational hormone in the panda urine or excrement is realized by detecting the intensity of a luminescent signal according to a standard curve. The invention provides a novel chemiluminescence immunoassay method, the sensitivity of the chemiluminescence immunoassay method is far higher than that of a traditional ELISA method (the lowest detection line can reach 31.25 pg / mL), the operation is simple and convenient, the detection is rapid, and the urgent demand on rapid and accurate determination of the hormone level in panda pregnancy monitoring and reproduction management can be met.

The present application relates to a kind of pituitary adenoma simulation teaching method, one aspect, in the case of unified time axis, with the volume of pituitary adenoma as the basis, the hormone level change of corresponding hormone species and visual change condition are associated, can clearly know the curve and numerical value of GH, PRL, ACTH, cortisol and other key hormones, the condition of real-time change with tumor state change, and the real-time synchronization of visual field change and the increase and decrease of tumor size, strengthen the understanding of "space-occupied effect-dysfunction" correlation of the trainee, and the degree of oppression of pituitary adenoma to surrounding tissue is quantified by pressure sensor, the compression phenomenon of pituitary adenoma volume change is directly reflected;Another aspect, for a large number of hormone species data, through the preset data ROI search algorithm, the position of data weak fluctuation can be accurately found, and the corresponding volume change moment of pituitary adenoma helps trainee to locate quickly key time point, improves learning efficiency.

The invention discloses an extract for promoting health and application thereof, and belongs to the technical field of medical and edible dual-purpose and traditional Chinese medicine health care, and the extract is a special extract obtained from beautiful millettia roots. The beautiful millettia root extract exerts new activity for promoting female health through a new mechanism, and the clinical effect is obviously improved. Experimental research proves that the extract promotes self-renewal of female germline stem cells and directional differentiation of the female germline stem cells into oocytes by promoting expression of Notch1, HES1 and HES5 in a Notch signal channel and regulates the female progestational hormone level, and shows the effects of promoting and recovering development of a second sexual character and preventing symptoms of polycystic ovarian syndrome on ovarian development disorder, and has a good application prospect. The radix millettiae speciosae extract is capable of promoting female physical development and maturation, delaying premature ovarian failure, relieving female depression and anxiety states and keeping female health, belongs to a new target and new mechanism, and makes up the mechanism blank of the radix millettiae speciosae extract in the aspect of keeping female health. The application has innovativeness.

The application relates to the field of biotechnology, and particularly relates to an application of Bacteroides ovatus in ovarian aging; the application comprises: taking low-abundance Bacteroides ovatus as a biomarker of ovarian aging; the application comprises using Bacteroides ovatus in a medicine for delaying ovarian aging; the application further comprises using a fermentation product of Bacteroides ovatus in the medicine for delaying ovarian aging; it is found through experiments that there is a significant difference in Bacteroides ovatus in mice with different degrees of ovarian aging, and it is found through subsequent experiments that Bacteroides ovatus has the effects of significantly increasing the number of oocytes, up-regulating anti-Mullerian hormone, up-regulating the level of estradiol and down-regulating the level of follicle-stimulating hormone, which indicates that Bacteroides ovatus can be used in the medicine for delaying ovarian aging.

The invention discloses application of exosome-like nanoparticles derived from fructus lycii to preparation of a medicine for preventing or treating oligospermia and / or asthenospermia. Sterile, stable and high-purity fructus lycii exosome-like nanoparticles (LBELNs) are obtained by adopting a differential centrifugation-suction filtration-ultra-high-speed centrifugation method, the physiological efficacy of the LBELNs is researched, and it is found that the LBELNs can significantly improve the oligoasthenospermia disease activity index of male mice induced by cyclophosphamide (CTX); the sperm quantity is obviously increased, the sperm malformation is improved, the sperm motility is improved, and the sex hormone level is recovered. The LBELNs can effectively relieve spermatogenic dysfunction of testicular tissues, the sperm differentiation and formation process is obviously improved, the total number of sperms is increased, and the treatment effect is more obvious along with increase of the dosage of the LBELNs. The invention has potential in preparation of drugs for preventing or treating oligoasthenospermia, and provides a new strategy and treatment method for treating oligoasthenospermia.

This invention discloses an AI-based personalized dynamic embryo culture system, belonging to the field of embryo culture technology. The system adopts a modular architecture, including a core control module, at least one independent culture chamber module, an AI analysis module, and a dynamic regulation module. By employing microfluidic chip technology and an integrated microsensor array, this invention achieves high-precision real-time monitoring of embryo morphology images and physiological parameters of the culture medium. Combined with multimodal data fusion analysis using the AI ​​analysis module, it significantly improves the accuracy and reliability of embryo developmental potential assessment, thereby contributing to increased rates of high-quality embryos and clinical pregnancy success. Furthermore, this invention, through a built-in personalized protocol generation unit, can dynamically generate and execute personalized culture protocols based on the patient's age, ovarian function indicators, and basal hormone levels, while utilizing the dynamic regulation module to simulate the uterine diurnal rhythm for temperature fluctuation control.

The invention relates to the technical field of microbial culture, and particularly discloses pediococcus pentosaceus NSS0402 and application thereof to improvement of polycystic ovarian syndrome. The invention relates to pediococcus pentosaceus NSS0402, which is preserved in China Center for Type Culture Collection (CCTCC) on July 1, 2024, the address is Wuhan University, Wuhan, China, the pediococcus pentosaceus NSS0402 is named as pediococcus pentosaceus, and the preservation number is CCTCC NO: M 20241421. The pediococcus pentosaceus NSS0402 can effectively improve the polycystic ovarian syndrome and related metabolic level disorder and sex hormone level abnormality symptoms thereof, and can be applied to preparation of products for preventing, relieving or treating the polycystic ovarian syndrome.

The application discloses a bird's nest compound product with the effect of improving female body health and a preparation method and application thereof. The preparation method comprises the following steps: mixing red ginseng, Gastrodia elata, ophiopogon, donkey-hide gelatin, eucommia and ganoderma lucidum with a solvent to form a mixed slurry; treating and extracting the mixed slurry by applying an electric field to prepare a compound liquid; and mixing the compound liquid with bird's nest to prepare the bird's nest compound product with the effect of improving female body health. The bird's nest is matched with the medicine-food homologous material, and on the basis of the theory of "suo zhuo jun chen", the bird's nest compound product capable of obviously improving menopausal syndrome is prepared, the hormone level is effectively adjusted, symptoms such as hot flashes, night sweats, sleep quality improvement, ovary and uterus repair promotion and the like are relieved, and the product is mild in action, high in safety, good in flavor and color.

This application discloses a nutritional meal recommendation system, method, equipment, and medium for post-gynecological surgery, relating to the field of digital health management technology and applied to a computer device. It includes: an association matrix acquisition module, used to construct dynamic physiological signs by combining the patient's hormone levels and blood loss after gynecological surgery, and splicing them according to time sequence and the nutritional ratio of candidate ingredients to generate a nutritional metabolism association matrix; an evolution matrix acquisition module, used to perform first-order differentiation and normalization of the matrix in the time dimension to construct a metabolic nutritional evolution feature matrix; a node sequence construction module, used to split feature vectors, construct a heterogeneous graph using gastrointestinal dynamic impedance, and use a graph attention network to screen ingredient nodes to form a sequence of nodes with absorption potential; and a meal plan generation module, used to calculate the nutritional difference in the sequence, extract decreasing topological fragments, and generate an individualized nutritional meal plan adapted to the patient's dynamic physiology and gastrointestinal capacity.

The present invention provides methods for treating conditions, diseases or disorders associated with sex hormone imbalance and specifically with a low sex hormone level or response using NAP peptide, specifically conditions, diseases or disorders mediated via unfolded protein response.

Provided herein are methods and compositions comprising pulsatile follicle stimulating hormone (FSH). The pulsatile FSH may be used in methods of treating infertility, restoring normal hormonal levels, stimulating secretion of a sex steroid, treating or preventing fatty tissue accumulation, treating or preventing loss of bone density, preventing ovarian inflammation, and / or promoting metabolic health.

The invention relates to the technical field of specific therapeutic activity of pharmaceutical preparations, in particular to a PRP administration concentration evaluation method for joint movement injury repair, which comprises the following steps: obtaining an inflammation comprehensive repair expression according to the change condition of multiple C-reactive protein levels before the last PRP administration; according to the change condition of the joint swelling degree in a time period between two adjacent C-reactive protein levels, joint swelling repair characteristics are obtained; determining the change correlation between the arthrocele repair characteristics and the C-reactive protein level, and combining the arthrocele repair characteristics and the inflammation comprehensive repair expression to obtain comprehensive repair effect characteristics; obtaining hormone level deviation characteristics according to multiple abnormal conditions of cortisol hormone levels; according to the comprehensive repair effect characteristics and the hormone level deviation characteristics, the next PRP administration concentration is adjusted, the accuracy and reliability of determining the PRP administration concentration are effectively improved, and therefore the overall effect of joint injury repair is improved.

This invention discloses the application of sturgeon roe peptides in improving premature ovarian failure and brain health, belonging to the field of bioactive peptide technology. The sturgeon roe peptides prepared by this invention have been experimentally verified to improve premature ovarian failure by improving hormone levels and enhancing antioxidant and anti-inflammatory capabilities, while also possessing brain health-improving effects. They can be widely used in common foods and medicines.

This application relates to a method and system for generating AMH test reports using multi-dimensional data fusion. The method includes extracting AMH samples from women of a specific age group and establishing a regression standard curve between age and the mean AMH value based on statistical distribution. The theoretical AMH value is obtained from the standard curve based on the patient's age, and combined with the actual test value to calculate the AMH standard offset reflecting the degree of deviation. Based on the statistical distribution of the sample set, a preset interval threshold reference range for the offset is set and simultaneously presented in the report as an evaluation benchmark. When the offset exceeds a preset risk threshold, multi-dimensional clinical data from the patient's historical diagnosis, hormone levels, and ultrasound are automatically collected and entered into the analysis process. The offset index, reference range, and multi-dimensional data mining results are fused to obtain structured and personalized report suggestions to assist in precise clinical decision-making.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating polycystic ovarian syndrome as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from Chinese yam, semen cuscutae, pulp of dogwood fruit, radix glehniae, radix scrophulariae, lily, rhizoma polygonati, tortoise shell, cistanche deserticola, lotus seed and raspberry, has the effects of tonifying kidney and replenishing essence, nourishing yin and blood, replenishing qi and tonifying spleen, and benefiting uterus and accommodating fetus, and is mainly used for treating the polycystic ovarian syndrome. Research results show that the traditional Chinese medicine composition can significantly improve the sex hormone level of a patient with the polycystic ovarian syndrome, increase the endometrial thickness, improve the ovarian function and improve the endometrial receptivity, the ovulation rate and the pregnancy rate. Therefore, the traditional Chinese medicine composition has important clinical significance and wide market application prospects.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

This invention discloses a compound moxa stick for warming yang and unblocking obstruction, its preparation method, and its application in improving reproductive system function. It belongs to the field of external preparations of traditional Chinese medicine. Addressing the problems of limited improvement effects of pure moxa sticks, lack of systematic design in compound moxa stick formulations, unclear synergistic effects between components, large fluctuations in conditioning effects, and difficulty in balancing conditioning effects and safety, this invention uses specific weight proportions of Artemisia argyi, Cyperus rotundus, Alpinia galanga, Cinnamomum cassia, Zingiber officinale, Illicium verum, Cinnamomum cassia twig, Spatholobus suberectus, Caesalpinia sappan, Smilax glabra, Euonymus fortunei, Citrus aurantium, Amomum villosum, Citrus reticulata peel, and Atractylodes lancea to prepare a compound moxa stick. The components synergistically enhance each other, and this product is used to prepare a moxibustion intervention product for improving the reproductive function of mammals. It can stably improve female ovarian reserve function and male asthenospermia, simultaneously regulate reproductive-related hormone levels, repair pathological damage to reproductive organs, and improve the quality of reproductive cells.

Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. More preferably, the modified oil phase droplets of the MOIW microemulsion directly solubilize nonderivatized hormones. The oil phase droplets of the MOIW microemulsion include DHEA, pregnenolone, and a polyphenol, where a ratio of DHEA to polyphenol is from 1:1 to 12:1 by weight. Methods of supporting and / or increasing bloodstream hormone levels in perimenopausal and postmenopausal females and improving menopausal symptoms also are disclosed.

The application relates to the technical field of GnRH pumps, in particular to a GnRH pump based on real-time hormone level dynamic adjustment of infusion amount and a use method thereof, the GnRH pump comprises a pump body, a real-time hormone monitoring module, a control module, an infusion execution module, a medicine storage module, a communication module and a power module, the real-time hormone monitoring module collects hormone signals in real time through a subcutaneous implantable LH / FSH sensor, an artificial intelligence algorithm is built in the control module, real-time data is compared with a standard range, infusion adjustment instructions are dynamically generated, and the infusion execution module accurately infuses GnRH drugs according to the instructions, the use method comprises device installation and parameter presetting, real-time hormone monitoring, dynamic adjustment analysis, accurate infusion execution, data transmission and remote monitoring.The application solves the defects that the existing GnRH pump has no real-time feedback and cannot be automatically adjusted, realizes monitoring-feedback-regulation closed-loop control, improves treatment accuracy and individualized adaptability, and is suitable for the treatment of diseases such as hypogonadotropic hypogonadism.

The present invention relates to Lacticaseibacillus paracasei HP7 with preventive or alleviative efficacy for functional dyspepsia and uses thereof. The composition comprising the Lacticaseibacillus paracasei HP7 strain (accession number: KCTC 13143 BP) of the present invention as an active ingredient was confirmed to increase expression of intestinal tight junction genes, improve gastrointestinal peristalsis and gastric emptying effects, enhances gastric weight and gastric emptying levels associated with gastric emptying, and significantly increase blood hormone levels related to digestive activity, thereby improving dyspepsia.

This invention belongs to the field of biomedical technology, specifically relating to the application of a composition in the preparation of a drug for the prevention and treatment of polycystic ovary syndrome (PCOS). The composition comprises bovine spleen peptide and adenosine; the mass ratio of bovine spleen peptide to adenosine is 1:(1-2.5). Bovine spleen peptide, as a bioactive polypeptide, significantly improves insulin resistance associated with PCOS by targeting and activating the PI3K-Akt signaling pathway and promoting insulin receptor substrate phosphorylation. Adenosine, as a natural bioactive substance, significantly reduces serum luteinizing hormone and testosterone levels in rats and increases follicle-stimulating hormone levels, thereby effectively alleviating hyperandrogenism symptoms such as hirsutism and acne in PCOS. Furthermore, this composition can significantly improve polycystic pathological changes in the ovarian tissue of model rats, reduce the number of cystic dilated follicles, restore the granulosa cell layer structure, alleviate ovarian stromal hyperplasia, and promote normal follicular development.

The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition for assisting pregnancy and implantation in a test tube and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following medicinal materials: teasel root, parasitic loranthus, semen cuscutae, radix paeoniae alba, liquorice, divaricate saposhnikovia root, roasted rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, ramie root, scutellaria baicalensis, Chinese yam, fructus amomi, coptis chinensis, dogwood, radix rehmanniae preparata, folium mori, bamboo shavings and loofah sponge charcoal. The traditional Chinese medicine composition can regulate spleen and kidney deficiency states, improve ovarian blood flow, improve serum sex hormone level, increase endometrial thickness and vascular endothelial growth factor expression, contribute to endometrial growth, improve endometrial receptivity, assist implantation and development of reproductive embryos and improve pregnancy success rate of patients, and has good application prospects. The traditional Chinese medicine composition has more obvious effect on patients with ovarian reserve function decline, and is worthy of clinical popularization and application.

The invention discloses an osmanthus fragrans extract for preventing premature ovarian failure and a preparation method and application thereof.The extract is prepared from osmanthus fragrans through microwave fixation, gradient temperature weak acid extraction, membrane separation and concentration, low-temperature drying and other pure physical processes, effective components can be prevented from being damaged, the process is stable, green and efficient, the active components are definite, and the preparation method is simple. Wherein the sum of the contents of the salidroside, the verbascoside and the ligustroside is not less than 20%. Animal experiments show that AMH, FSH and LH hormone levels in mice suffering from premature ovarian failure induced by cyclophosphamide can be remarkably improved, the ovarian function can be effectively improved, all index components including salidroside, verbascoside and ligustrum glycoside have a synergistic interaction effect, a safe and effective solution scheme derived from natural plants is provided for preventing premature ovarian failure, and the application prospect is wide. The method can be widely applied to preparation of various products.

The application relates to the technical field of traditional Chinese medicine, and discloses a preparation method of a medicine for lactation promotion of puerpera. The medicine composition for treating dysfunctional uterine bleeding is originally used for treating excessive menstruation and prolonged menstruation of women. The improved preparation method uses a supercritical CO2 extraction method to extract volatile oil, so that the medicine composition for treating dysfunctional uterine bleeding has higher efficacy and can be fully exerted. Through experiments, it is verified that when the improved medicine composition is used for lactation promotion of puerpera, the medicine composition can help to increase the levels of estradiol and progesterone hormones to regulate hormone imbalance, act on developed mammary glands to promote the increase of lactation, and has small toxic and side effects and reduces the burden of the liver.

The application discloses a traditional Chinese medicine composition for auxiliary treatment of prostatic hypertrophy and a preparation method thereof. The traditional Chinese medicine composition is prepared from Uncaria, ethanol extract of Dehaasia bibracteata, Akebia quinata, Nelumbo nucifera, Crossandra infundibuliformis, Rosmarinus officinalis, Prunus armeniaca, Cinnamomum cassia and Salvia officinalis by processing. The traditional Chinese medicine composition has the effect of treating prostatic hypertrophy. The traditional Chinese medicine composition is mainly used for prostatic hypertrophy, and the symptoms include frequent urination, urgent urination and incomplete urination. The traditional Chinese medicine composition can reduce the prostate index of a patient with prostatic hypertrophy, regulate the sex hormone level, reduce the prostate phosphatase activity, and has a remarkable effect on treating the problems of frequent urination, urgent urination and incomplete urination caused by prostatic hypertrophy. Meanwhile, the composition is prepared from traditional Chinese medicines as raw materials, is safe to use, has high bioavailability, and has no any toxic and side effects.

A system for sensing one or more physiological traits and obstetric conditions, such as a fertility phase, pregnancy, labor, post-partum conditions, and other conditions related to the reproductive system of the patient. The system may use the one or more physiological traits sensed to define one or more patient attributes for the patient, such as a hormone level, heart rate, blood pressure, respiration rate, temperature, oxygen saturation level, uterine contractions, fluid level, and / or other patient attributes. The system is configured to compare the one or more patient attributes to one or more attribute signs describing a threshold for the one or more patient attributes. The system is configured to issue a communication to the patient and / or a clinician based on the comparisons. The system may be configured to assess and indicate reproductive phases for the patient over a life-cycle from the fertility phase to the post-partum phase.

The invention relates to the technical field of gene engineering, in particular to a cotton gene GhAGL15 and application thereof. The GhAGL15 gene is identified in cotton, overexpression of GhAGL15 can significantly promote embryogenic callus induction of cotton, accelerate somatic embryo formation and improve the overall regeneration efficiency, hormone level determination finds that gibberellin in a GhAGL15 knockout strain is significantly accumulated, the cytokinin level in an overexpression strain is significantly increased, and the GhAGL15 knockout strain can be used as a GhAGL15 gene. It is prompted that GhAGL15 can play a role by regulating and controlling metabolism or signal pathways of gibberellin and cytokinin by regulating and controlling far-end regulation and control areas of related genes of gibberellin and cytokinin. And a basis is provided for breeding excellent cotton varieties.

The invention belongs to the technical field of medical application, and particularly relates to a traditional Chinese medicine application for improving gastrointestinal discomfort and a preparation method thereof. The traditional Chinese medicine patch for improving gastrointestinal discomfort comprises the following raw materials in parts by weight: 20-25 parts of clove, 18-22 parts of codonopsis pilosula, 13-18 parts of semen raphani, 10-15 parts of linaria lingua, 5-10 parts of pinellia ternate, 9-13 parts of fingered citron, 6-11 parts of maple and 3-8 parts of liquorice. The traditional Chinese medicine prescription provided by the invention is safe, non-toxic and mild in medicine property, and can tonify without stagnation and warm without dryness. The traditional Chinese medicine patch disclosed by the invention can regulate the gastrointestinal hormone level and promote motilin secretion, so that the gastric emptying rate and the small intestine propulsion rate are improved, the gastrointestinal motility is enhanced, the digestive function is improved, and the traditional Chinese medicine patch shows good potential in the aspect of improving gastrointestinal discomfort.