141 results about "Hormones levels" patented technology

The invention provides a strain of lactobacillus plantarum YS-AG23 with high antioxidant activity, and a rhizoma polygonati and radix angelicae sinensis fermented product obtained by fermenting rhizoma polygonati and radix angelicae sinensis with the strain of lactobacillus plantarum YS-AG23. In a D-galactose induced premature ovarian failure mouse model, the fermentation product can regulate up the levels of antioxidant and stress protection genes SOD2 and HO-1 and an anti-aging gene SIRT1 by regulating down the expression of a key gene AGER of an inflammation and oxidative stress pathway, so that the oxidative stress and inflammatory response of model mouse ovarian tissues are remarkably reduced; meanwhile, the serum hormone level can be specifically adjusted, the serum estradiol (E2) level can be increased, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels can be reduced to be close to the normal range, the expression of anti-mullerian hormone (AMH) and hormone regulatory gene LHR of ovarian reserve markers can be up-regulated, the proliferative activity and estrogen secretion function of follicular granulosa cells can be improved, and the effect of preventing ovarian reserve is achieved. The wet weight of atrophic uterus and ovary of the model mouse is remarkably increased, uterine and ovary atrophy is effectively reversed, and the ovarian reserve function of the D-galactose induced premature ovarian failure model mouse is recovered. Besides, in an H2O2-induced human dermal fibroblast aging model, the yeast can improve the activity of aging cells in a concentration-dependent manner and reduce the level of reactive oxygen species (ROS) in the cells; in addition, by up-regulating the expression of a collagen synthesis key gene COL1A1 and down-regulating the expression of a cell senescence marker gene p16, skin cell senescence caused by oxidative stress can be effectively improved. In conclusion, the polygonatum sibiricum and angelica sinensis leavening can synchronously improve premature ovarian failure and skin cell senescence caused by oxidative stress by accurately regulating and controlling oxidative stress, inflammatory response and tissue function related genes, and has wide application potential.

The invention belongs to the technical field of biological medicines, and discloses application of beta-elemonic acid or derivatives thereof or pharmaceutically acceptable salts thereof in preparation of medicines for preventing and / or treating polycystic ovarian syndrome (PCOS). The beta-elemonic acid is screened from a medicinal and edible library, and experiments prove that the beta-elemonic acid can remarkably improve the PCOS ovarian form and the number of mature follicles, normalize the disordered estrus cycle, remarkably improve the serum hormone level and further remarkably improve the sugar tolerance, insulin tolerance and weight of PCOS. The beta-elemonic acid disclosed by the invention is a compound based on homology of medicine and food, can be used as a medicine as well as a natural ingredient of food, is relatively low in toxicity, ensures the safety after long-term use, is relatively low in safety evaluation cost of a relatively brand-new synthetic compound, and can be applied to development and preparation of a medicine or a lead compound thereof for preventing and / or treating PCOS, or a health care product.

The invention relates to the technical field of defect detection, in particular to a thyroid ultrasonic auxiliary scanning method and system, and the method comprises the following steps: obtaining a pixel gray value, local contrast and edge sharpness of a thyroid ultrasonic image, calculating a pixel gradient change rate, and screening a thyroid gland boundary region according to the gradient amplitude change rate. According to the method, the pixel gradient change rate is calculated, the boundary region is screened, the gland recognition accuracy is enhanced, noise interference is reduced, the boundary segmentation is optimized in combination with the multi-scale gradient change rate and the edge strength, the error recognition probability is reduced, the gradient difference weight matrix is constructed, and the boundary is adjusted based on the gray level uniformity, so that the segmentation is more in line with the tissue form; the low-contrast lesion detection capability is improved in combination with gray shift, gradient direction distribution and morphological parameters, the classification accuracy is improved through matching of the morphological change rate and global features, diagnosis support is optimized in combination with the gland volume, the hormone level and the lesion morphological ratio, and the credibility of personalized diagnosis is improved.

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating ovarian dysfunction, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 8-10 parts of American ginseng, 2-4 parts of pseudo-ginseng, 55-65 parts of kudzuvine root, 42-48 parts of coptis chinensis, 42-48 parts of scutellaria baicalensis, 14-16 parts of stiff silkworm, 14-16 parts of rhizoma zingiberis, 42-48 parts of bitter gourd and 55-65 parts of rhizoma anemarrhenae. The traditional Chinese medicine composition has the effects of increasing the number of follicles and corpus luteum, restoring the duration of an estrus cycle and restoring the levels of serum hormones and sex hormone receptors. The traditional Chinese medicine composition provided by the invention provides a new means for preventing and treating ovarian dysfunction.

Disclosed herein are compositions and methods for treating diabetes, wherein the compositions comprise a GLP-1 agonist. The disclosed compositions are also effective in reducing body weight and improving triglyceride and cholesterol levels. Disclosed herein are methods for treating type 2 diabetes mellitus in a subject, for reducing A1C in a subject, for reducing body mass in a subject, and for modulating a hypoglycemic hormone level in a subject.

The present application relates to the field of biological medicine and modernization of traditional Chinese medicine, and particularly relates to a therapeutic target, an inhibitor and a traditional Chinese medicine composition for treating ovarian hypofunction caused by oxidative stress and application thereof. The present application first determines SRC tyrosine kinase as a key drug target for preventing and treating the disease. The application of the SRC tyrosine kinase inhibitor (such as secaitinib) in preparing related drugs is provided, which can alleviate the damage of ovarian granulosa cells by inhibiting the SRC activity, down-regulating the expression of antioxidant enzyme related genes and reducing the level of active oxygen. Meanwhile, the present application provides a traditional Chinese medicine composition composed of mulberry, kudzu root, tuckahoe and medlar. The composition can improve the hormone level, enhance the antioxidant capacity, improve the ovarian function and fertility by inhibiting the SRC tyrosine kinase activity and the SRC-RAF1-MEK-ERK signal pathway. The present application provides a new solution for the targeted treatment of ovarian hypofunction and the modernization of traditional Chinese medicine.

The invention relates to an application of a DIO1 gene in a liver in controlling the body color of a turbot, and belongs to the field of molecular biology, and the application method is as follows: the turbot with golden body color is obtained by overexpressing the DIO1 gene in the liver of the turbot; the amino acid sequence of the protein coded by the DIO1 gene is as shown in SEQ ID NO. 1. The invention discovers that the gene expression level change in the liver can cause the change of the blood hormone level by influencing the thyroid hormone pathway in the turbot for the first time, thereby influencing the color formation of the skin; therefore, the formation of the target body color of the scophthalmus maximus can be controlled by controlling the gene expression level, so that the market value of the scophthalmus maximus is improved.

The invention discloses a chemiluminescence immunoassay method and kit for detecting progestational hormone of pandas, and belongs to the technical field of biological detection. The specific process comprises the following steps: by taking goat anti-mouse IgG as a coating antibody, enabling a progestational hormone standard substance or a to-be-detected sample and horse radish peroxidase labeled progestational hormone to compete with a limited amount of progestational hormone antibodies together; after incubation and washing, a chemiluminescent substrate is added, and quantitative analysis of the progestational hormone in the panda urine or excrement is realized by detecting the intensity of a luminescent signal according to a standard curve. The invention provides a novel chemiluminescence immunoassay method, the sensitivity of the chemiluminescence immunoassay method is far higher than that of a traditional ELISA method (the lowest detection line can reach 31.25 pg / mL), the operation is simple and convenient, the detection is rapid, and the urgent demand on rapid and accurate determination of the hormone level in panda pregnancy monitoring and reproduction management can be met.

An Artificial Intelligence (AI) system trained by a plurality of training data. The AI system is trained by relationships between a time to final menstrual period and ratios between follicle-stimulating hormone levels and estradiol levels, anti-mullerian hormone, race, cholesterol levels, and a presence of one or more contraceptives. The AI system is configured to accept data from only one sample from a user as input and generate a prediction of a time to final menstrual period for the user as output.

The invention discloses a synergistic anti-oxidation urolithin A composition and application thereof in improving the ovarian function direction, and relates to the technical field of biological medicine, and the active ingredients of the composition comprise 10-100 parts of urolithin A and 6-40 parts of coenzyme Q10. According to the composition disclosed by the invention, the used raw materials are food-grade raw materials such as urolithin A and coenzyme Q10, and the urolithin A and the coenzyme Q10 are matched within a certain range, so that a good synergistic interaction effect can be achieved, and the composition has a good antioxidant effect; meanwhile, the composition also has the effects of effectively improving the ovarian reserve function, regulating the hormone level, improving menstruation, skin, emotion, sleep and the like at a low dosage level, and is effective and safe.

The present application relates to a kind of pituitary adenoma simulation teaching method, one aspect, in the case of unified time axis, with the volume of pituitary adenoma as the basis, the hormone level change of corresponding hormone species and visual change condition are associated, can clearly know the curve and numerical value of GH, PRL, ACTH, cortisol and other key hormones, the condition of real-time change with tumor state change, and the real-time synchronization of visual field change and the increase and decrease of tumor size, strengthen the understanding of "space-occupied effect-dysfunction" correlation of the trainee, and the degree of oppression of pituitary adenoma to surrounding tissue is quantified by pressure sensor, the compression phenomenon of pituitary adenoma volume change is directly reflected;Another aspect, for a large number of hormone species data, through the preset data ROI search algorithm, the position of data weak fluctuation can be accurately found, and the corresponding volume change moment of pituitary adenoma helps trainee to locate quickly key time point, improves learning efficiency.

The invention discloses an extract for promoting health and application thereof, and belongs to the technical field of medical and edible dual-purpose and traditional Chinese medicine health care, and the extract is a special extract obtained from beautiful millettia roots. The beautiful millettia root extract exerts new activity for promoting female health through a new mechanism, and the clinical effect is obviously improved. Experimental research proves that the extract promotes self-renewal of female germline stem cells and directional differentiation of the female germline stem cells into oocytes by promoting expression of Notch1, HES1 and HES5 in a Notch signal channel and regulates the female progestational hormone level, and shows the effects of promoting and recovering development of a second sexual character and preventing symptoms of polycystic ovarian syndrome on ovarian development disorder, and has a good application prospect. The radix millettiae speciosae extract is capable of promoting female physical development and maturation, delaying premature ovarian failure, relieving female depression and anxiety states and keeping female health, belongs to a new target and new mechanism, and makes up the mechanism blank of the radix millettiae speciosae extract in the aspect of keeping female health. The application has innovativeness.

The application relates to the field of biotechnology, and particularly relates to an application of Bacteroides ovatus in ovarian aging; the application comprises: taking low-abundance Bacteroides ovatus as a biomarker of ovarian aging; the application comprises using Bacteroides ovatus in a medicine for delaying ovarian aging; the application further comprises using a fermentation product of Bacteroides ovatus in the medicine for delaying ovarian aging; it is found through experiments that there is a significant difference in Bacteroides ovatus in mice with different degrees of ovarian aging, and it is found through subsequent experiments that Bacteroides ovatus has the effects of significantly increasing the number of oocytes, up-regulating anti-Mullerian hormone, up-regulating the level of estradiol and down-regulating the level of follicle-stimulating hormone, which indicates that Bacteroides ovatus can be used in the medicine for delaying ovarian aging.

The invention provides application of rosa roxburghii tratt fruit extract in preparation of drugs or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. The invention belongs to the technical field of biological medicines, and provides application of a roxburgh rose extract in preparation of medicines or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. Animal experiments prove that the rosa roxburghii tratt extract can effectively improve mouse prostate fibrosis and bladder urinary retention caused by high fat diet and relieve lower urinary tract symptoms by regulating lipid metabolism, resisting inflammation, resisting oxidative stress, regulating sex hormone level and inhibiting a TGF-beta / Smad signal channel.

The invention discloses application of exosome-like nanoparticles derived from fructus lycii to preparation of a medicine for preventing or treating oligospermia and / or asthenospermia. Sterile, stable and high-purity fructus lycii exosome-like nanoparticles (LBELNs) are obtained by adopting a differential centrifugation-suction filtration-ultra-high-speed centrifugation method, the physiological efficacy of the LBELNs is researched, and it is found that the LBELNs can significantly improve the oligoasthenospermia disease activity index of male mice induced by cyclophosphamide (CTX); the sperm quantity is obviously increased, the sperm malformation is improved, the sperm motility is improved, and the sex hormone level is recovered. The LBELNs can effectively relieve spermatogenic dysfunction of testicular tissues, the sperm differentiation and formation process is obviously improved, the total number of sperms is increased, and the treatment effect is more obvious along with increase of the dosage of the LBELNs. The invention has potential in preparation of drugs for preventing or treating oligoasthenospermia, and provides a new strategy and treatment method for treating oligoasthenospermia.

This invention discloses an AI-based personalized dynamic embryo culture system, belonging to the field of embryo culture technology. The system adopts a modular architecture, including a core control module, at least one independent culture chamber module, an AI analysis module, and a dynamic regulation module. By employing microfluidic chip technology and an integrated microsensor array, this invention achieves high-precision real-time monitoring of embryo morphology images and physiological parameters of the culture medium. Combined with multimodal data fusion analysis using the AI ​​analysis module, it significantly improves the accuracy and reliability of embryo developmental potential assessment, thereby contributing to increased rates of high-quality embryos and clinical pregnancy success. Furthermore, this invention, through a built-in personalized protocol generation unit, can dynamically generate and execute personalized culture protocols based on the patient's age, ovarian function indicators, and basal hormone levels, while utilizing the dynamic regulation module to simulate the uterine diurnal rhythm for temperature fluctuation control.

The invention relates to the technical field of microbial culture, and particularly discloses pediococcus pentosaceus NSS0402 and application thereof to improvement of polycystic ovarian syndrome. The invention relates to pediococcus pentosaceus NSS0402, which is preserved in China Center for Type Culture Collection (CCTCC) on July 1, 2024, the address is Wuhan University, Wuhan, China, the pediococcus pentosaceus NSS0402 is named as pediococcus pentosaceus, and the preservation number is CCTCC NO: M 20241421. The pediococcus pentosaceus NSS0402 can effectively improve the polycystic ovarian syndrome and related metabolic level disorder and sex hormone level abnormality symptoms thereof, and can be applied to preparation of products for preventing, relieving or treating the polycystic ovarian syndrome.

The application discloses a bird's nest compound product with the effect of improving female body health and a preparation method and application thereof. The preparation method comprises the following steps: mixing red ginseng, Gastrodia elata, ophiopogon, donkey-hide gelatin, eucommia and ganoderma lucidum with a solvent to form a mixed slurry; treating and extracting the mixed slurry by applying an electric field to prepare a compound liquid; and mixing the compound liquid with bird's nest to prepare the bird's nest compound product with the effect of improving female body health. The bird's nest is matched with the medicine-food homologous material, and on the basis of the theory of "suo zhuo jun chen", the bird's nest compound product capable of obviously improving menopausal syndrome is prepared, the hormone level is effectively adjusted, symptoms such as hot flashes, night sweats, sleep quality improvement, ovary and uterus repair promotion and the like are relieved, and the product is mild in action, high in safety, good in flavor and color.

This application discloses a nutritional meal recommendation system, method, equipment, and medium for post-gynecological surgery, relating to the field of digital health management technology and applied to a computer device. It includes: an association matrix acquisition module, used to construct dynamic physiological signs by combining the patient's hormone levels and blood loss after gynecological surgery, and splicing them according to time sequence and the nutritional ratio of candidate ingredients to generate a nutritional metabolism association matrix; an evolution matrix acquisition module, used to perform first-order differentiation and normalization of the matrix in the time dimension to construct a metabolic nutritional evolution feature matrix; a node sequence construction module, used to split feature vectors, construct a heterogeneous graph using gastrointestinal dynamic impedance, and use a graph attention network to screen ingredient nodes to form a sequence of nodes with absorption potential; and a meal plan generation module, used to calculate the nutritional difference in the sequence, extract decreasing topological fragments, and generate an individualized nutritional meal plan adapted to the patient's dynamic physiology and gastrointestinal capacity.

The invention relates to the technical field of animal feeds, in particular to a mouse feed and a preparation method and application thereof, and the mouse feed comprises curcumin and a basic ration; wherein the curcumin is provided in the form of a drug-loaded pellet; the basic ration is SPF (specific pathogen free) grade rat ration. The feed for the rats contains curcumin, effectively relieves damage of the plateau low-oxygen environment to the reproductive system of the rats, improves sperm motility, reduces the malformation rate, adjusts the reproductive hormone level, and provides an innovative solution for plateau animal reproductive health management.

The present invention provides methods for treating conditions, diseases or disorders associated with sex hormone imbalance and specifically with a low sex hormone level or response using NAP peptide, specifically conditions, diseases or disorders mediated via unfolded protein response.

Provided herein are methods and compositions comprising pulsatile follicle stimulating hormone (FSH). The pulsatile FSH may be used in methods of treating infertility, restoring normal hormonal levels, stimulating secretion of a sex steroid, treating or preventing fatty tissue accumulation, treating or preventing loss of bone density, preventing ovarian inflammation, and / or promoting metabolic health.

The invention relates to the technical field of specific therapeutic activity of pharmaceutical preparations, in particular to a PRP administration concentration evaluation method for joint movement injury repair, which comprises the following steps: obtaining an inflammation comprehensive repair expression according to the change condition of multiple C-reactive protein levels before the last PRP administration; according to the change condition of the joint swelling degree in a time period between two adjacent C-reactive protein levels, joint swelling repair characteristics are obtained; determining the change correlation between the arthrocele repair characteristics and the C-reactive protein level, and combining the arthrocele repair characteristics and the inflammation comprehensive repair expression to obtain comprehensive repair effect characteristics; obtaining hormone level deviation characteristics according to multiple abnormal conditions of cortisol hormone levels; according to the comprehensive repair effect characteristics and the hormone level deviation characteristics, the next PRP administration concentration is adjusted, the accuracy and reliability of determining the PRP administration concentration are effectively improved, and therefore the overall effect of joint injury repair is improved.

Tracking ovulatory hormone levels is key to detecting fertility windows and providing actionable information for facilitating or preventing conception, as well as assessing and managing infertility and other conditions associated with hormone imbalances. Conventional fertility methods suffer drawbacks associated with invasive sampling, inadequate prediction accuracies, or repetitive user intervention. To overcome these and other limitations, the present Applicants developed a wearable device for contemporaneous monitoring of estradiol, progesterone, and luteinizing hormone and physiological biomarkers (temperature, pH). Flexible field-effect transistors functionalized with biomarker-specific aptamers enabled sensitive and selective determination of the three principal ovulatory hormones across physiological ranges in artificial human sweat. By including an on-demand iontophoretic sweat sampling feature, the present Applicants established an integrated wearable platform for high-accuracy, minimally invasive, rapid, and personalized ovulatory status monitoring.

This invention discloses the application of sturgeon roe peptides in improving premature ovarian failure and brain health, belonging to the field of bioactive peptide technology. The sturgeon roe peptides prepared by this invention have been experimentally verified to improve premature ovarian failure by improving hormone levels and enhancing antioxidant and anti-inflammatory capabilities, while also possessing brain health-improving effects. They can be widely used in common foods and medicines.

This application relates to a method and system for generating AMH test reports using multi-dimensional data fusion. The method includes extracting AMH samples from women of a specific age group and establishing a regression standard curve between age and the mean AMH value based on statistical distribution. The theoretical AMH value is obtained from the standard curve based on the patient's age, and combined with the actual test value to calculate the AMH standard offset reflecting the degree of deviation. Based on the statistical distribution of the sample set, a preset interval threshold reference range for the offset is set and simultaneously presented in the report as an evaluation benchmark. When the offset exceeds a preset risk threshold, multi-dimensional clinical data from the patient's historical diagnosis, hormone levels, and ultrasound are automatically collected and entered into the analysis process. The offset index, reference range, and multi-dimensional data mining results are fused to obtain structured and personalized report suggestions to assist in precise clinical decision-making.

The invention relates to the technical field of animal nutrition and reproduction, and discloses application of arginine in luteinization of replacement gilts. The arginine is used as a nutritional supplement for regulating and controlling the hormone level of the replacement gilts, the progesterone content can be effectively increased, and corpus luteum generation is promoted. Meanwhile, after the porcine ovarian granular cells are cultured, arginine can up-regulate expression of genes related to synthesis of progesterone and down-regulate expression of genes related to synthesis of estrogen, so that the progesterone is increased, the estrogen is reduced, and the effects of increasing the generation quantity of corpus luteum and maintaining a good pregnancy environment are achieved. According to the invention, 0.5% of arginine is directly added into the pig daily ration, so that the progesterone content in follicular fluid and serum can be remarkably increased, the estrogen content can be reduced, the quantity of small corpus luteum can be increased, and the pregnancy quality and success rate of the replacement gilts after mating can be improved. According to the invention, the problem of hormone level regulation can be solved, and a new nutrition regulation target is provided for increasing the luteum generation of the replacement gilts and improving the reproductive performance of the gilts.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating polycystic ovarian syndrome as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from Chinese yam, semen cuscutae, pulp of dogwood fruit, radix glehniae, radix scrophulariae, lily, rhizoma polygonati, tortoise shell, cistanche deserticola, lotus seed and raspberry, has the effects of tonifying kidney and replenishing essence, nourishing yin and blood, replenishing qi and tonifying spleen, and benefiting uterus and accommodating fetus, and is mainly used for treating the polycystic ovarian syndrome. Research results show that the traditional Chinese medicine composition can significantly improve the sex hormone level of a patient with the polycystic ovarian syndrome, increase the endometrial thickness, improve the ovarian function and improve the endometrial receptivity, the ovulation rate and the pregnancy rate. Therefore, the traditional Chinese medicine composition has important clinical significance and wide market application prospects.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

This invention discloses a compound moxa stick for warming yang and unblocking obstruction, its preparation method, and its application in improving reproductive system function. It belongs to the field of external preparations of traditional Chinese medicine. Addressing the problems of limited improvement effects of pure moxa sticks, lack of systematic design in compound moxa stick formulations, unclear synergistic effects between components, large fluctuations in conditioning effects, and difficulty in balancing conditioning effects and safety, this invention uses specific weight proportions of Artemisia argyi, Cyperus rotundus, Alpinia galanga, Cinnamomum cassia, Zingiber officinale, Illicium verum, Cinnamomum cassia twig, Spatholobus suberectus, Caesalpinia sappan, Smilax glabra, Euonymus fortunei, Citrus aurantium, Amomum villosum, Citrus reticulata peel, and Atractylodes lancea to prepare a compound moxa stick. The components synergistically enhance each other, and this product is used to prepare a moxibustion intervention product for improving the reproductive function of mammals. It can stably improve female ovarian reserve function and male asthenospermia, simultaneously regulate reproductive-related hormone levels, repair pathological damage to reproductive organs, and improve the quality of reproductive cells.