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Template copolymerizing synthetic process of semi-intercrossing network reversible pH sensitive aquagel

A technology of semi-interpenetrating network and synthesis method is applied in the field of template copolymerization method to synthesize semi-interpenetrating network reversible pH-sensitive hydrogel, which can solve the problems of poor mechanical properties and recoverability, affecting gel swelling/shrinking properties, etc. Achieve the effect of rapid volume expansion or contraction, high recovery rate and good mechanical properties

Inactive Publication Date: 2006-09-20
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Multi-component hydrogels are usually obtained by copolymerization, but the copolymer gel obtained by the general copolymerization method has ionic monomers distributed in a disordered state in the polymer chain, which affects the swelling / shrinking properties of the gel. In particular, its mechanical properties and recoverability are poor

Method used

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  • Template copolymerizing synthetic process of semi-intercrossing network reversible pH sensitive aquagel
  • Template copolymerizing synthetic process of semi-intercrossing network reversible pH sensitive aquagel
  • Template copolymerizing synthetic process of semi-intercrossing network reversible pH sensitive aquagel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Synthesis of acrylamide / acrylic acid / polyallylammonium chloride semi-interpenetrating network reversible pH-sensitive hydrogel copolymers.

[0033] In the reactor, add 35.5g (0.50mol) acrylamide, 15.43g (0.21mol) acrylic acid, 2.01g (0.021mol) polyallyl ammonium chloride, 0.11gN, N'-methylenebisacrylamide, 41ml Deionized water, adjust the pH with sodium carbonate to be 5.5, feed high-purity nitrogen into the reactor for 30 minutes, add initiator azobisisobutylamidine hydrochloride 0.035g (0.07wt% monomer weight), continue to feed nitrogen for 10 minutes Minutes, react at 65°C for 15 hours to obtain a white cross-linked polymer gel, cut the gel into small pieces about 1 cm in size, soak in deionized water, change the water every 8 hours, and continue soaking for 48 hour, filter off the water, add acetone to dehydrate the gel, and then vacuum-dry at 50°C to constant weight to obtain a xerogel. The molar ratio of acrylic acid to acrylamide in this gel is 0.43 / 1, and acryli...

Embodiment 2

[0035] Synthesis of acrylamide / acrylic acid / polyallylammonium chloride semi-interpenetrating network reversible pH-sensitive hydrogel copolymers.

[0036] In the reactor, add 0.2g (0.0028mol) acrylamide, 1.8g (0.025mol) acrylic acid, 4.66g (0.05mol) polyallyl ammonium chloride, 0.428g N, N'-methylenebisacrylamide, 95ml of deionized water, adjust the pH to 10 with potassium hydroxide, add 0.1g of initiator ammonium persulfate, and react at 40°C for 15 hours. The post-treatment process was the same as in Example 1 to obtain a xerogel, in which the molar ratio of acrylic acid to acrylamide was 8.93 / 1, and the molar ratio of acrylic acid to template polyallyl ammonium chloride was 1 / 2.

Embodiment 3

[0038] Synthesis of acrylamide / acrylic acid / polyallylammonium chloride semi-interpenetrating network reversible pH-sensitive hydrogel copolymers.

[0039] In the reactor, add 6.0g (0.085mol) acrylamide, 4.0g (0.056mol) acrylic acid, 5.24g (0.056mol) polyallyl ammonium chloride, 0.22g N, N'-methylene bisacrylamide, 85ml of deionized water, adjusted to pH 6.5 with potassium carbonate. Add 0.1 g of initiator azobisisobutylamidine hydrochloride, and react at 60° C. for 15 hours. The post-treatment process was the same as in Example 1 to obtain a xerogel, in which the molar ratio of acrylic acid to acrylamide was 0.66 / 1, and the molar ratio of acrylic acid to template polyallyl ammonium chloride was 1 / 1.

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Abstract

This invention especially relates to the synthesis of reversible semi-interpenetrating pH sensitive hydrogel by template copolymerization. For the synthesis, a pH sensitive ionic monomer is elected and an opposite-charged polymer is adopted as template. The two are copolymerized to obtain a gel product, where there exist not only covalent bond cross-links but also ionic bond cross-links by electrostatic bonding interaction so that both the gel strength and the pH sensitivity are enhanced. As there are pH sensitive ionic monomer units is the copolymer, ionic density varies with pH value of the solution; when the ionic density reaches a certain value, the gel begins to swell. And thanks to the existence of opposite charged ionic template polymer in the gel, the threshold of pH sensitivity can be adjusted.

Description

technical field [0001] The invention belongs to the field of functional macromolecules, and in particular relates to the synthesis of semi-interpenetrating network reversible pH-sensitive hydrogels by a template copolymerization method. Background technique [0002] In recent years, hydrogel, as a kind of smart material, can sense changes in the pH, temperature, ionic strength, and electric field of the environment, and it will change from a shrinking state to a swelling state, or from a swelling state to a shrinking state. , a significant change in volume occurs, and it has both sensing and passive functions, so it has broad application prospects in biomedicine, pharmaceutical applications, enzyme activity control, molecular separation, etc. (Synthesis and Characterization of pH- and Temperature-sensitive Poly( methacrylic acid) / Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks, Jing Zhang, Nicholas A.Peppas, Macromolecules, 2000, 33, 102-107. pH- and temperat...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F220/26C08F2/44C08F4/34C08F4/04
Inventor 吴飞鹏张玉玺李妙贞王尔鑑
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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