Methods for treating
carpal tunnel syndrome and tarsal tunnel syndrome in a subject involve providing an effective amount of an anti-
cytokine agent at or near
inflammation in the carpal or tarsal tunnel. Anti-
cytokine agents, such as, TNF-a inhibitors, NF-κB inhibitors, IL-1 inhibitors, IL-6 inhibitors, IL-8 inhibitors, IL-12 inhibitors, IL-15 inhibitors, IL-10,
Interferon-gamma (IFN-?) act to prevent further
inflammation initiated by
cytokine factors. One embodiment includes, adding with the anti-cytokine agent one or more of an antibiotic or
analgesic. Delivery of the anti-cytokine agent may be provided to the inflamed tissue of the carpal or tarsal tunnel by injection, implantation, or a
transdermal patch. These agents, individually or in combination, directly address the underlying
inflammation that causes the discomfort, pain, and restricted movement associated with carpal and tarsal tunnel syndrome.