The invention relates to the technical field of computer-aided
surgery, and discloses an operation navigation method, device and equipment based on
spatial positioning and imaging and a medium, and the method comprises the following steps: establishing registration mapping of a
spatial positioning coordinate
system and an imaging coordinate
system, and obtaining three-dimensional
imaging data of a target area and the position and posture of a target instrument; the position of the target instrument is converted to an imaging coordinate
system to generate target instrument position data, the data and the three-dimensional
imaging data are fused to form three-dimensional navigation data, an
entry point and a target point are selected through an interface to generate an operation path, a three-dimensional navigation view is generated to display the
imaging data, the operation path and a target instrument position mark in an overlapping mode, and the operation path is displayed. Continuously acquiring the position data of the target instrument, and generating and outputting prompt information according to the position relationship between the position data and the operation path. By fusing the position data of the target instrument and the three-dimensional imaging data, real-time registration of
spatial positioning and imaging is realized, an operation path and prompt information are dynamically generated, and the precision and real-time performance of navigation guidance are improved.