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Selenium nano-particles and preparation method thereof

A nanoparticle, selenium nanotechnology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve problems such as difficulty in exerting biological or medical effects, unsatisfactory stability of nano selenium particles, loss, etc. problems to achieve good bioavailability and biological effects

Inactive Publication Date: 2016-12-14
温彩珑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of the nano-selenium particles prepared in this document is not very satisfactory. As time goes by, for example, when stored at room temperature for about one month, it is easy to aggregate into micron-sized selenium particles and even produce visible precipitation in the solution, thereby losing its high Bioavailability, difficult to exert biological or medical effects

Method used

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  • Selenium nano-particles and preparation method thereof
  • Selenium nano-particles and preparation method thereof
  • Selenium nano-particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Sodium Selenite (99.99%), L-Cysteine ​​(99.99%), Apple Pectin, and stored in a dry box. Water is distilled before use. 15g of apple pectin was added to 1000ml of 100mM sodium selenite solution. L-cysteine ​​was continuously added to the solution until the final concentration of L-cysteine ​​reached 400 mM, and the resulting mixture was stirred at 50° C. for 10 hours. Sodium ions and oxidized L-cysteine ​​were then removed by dialysis, and the solution thus obtained contained amorphous selenium particles protected by apple pectin.

[0053] The resulting amorphous selenium particles were characterized by transmission electron microscopy. like figure 1 As shown, selenium nanoparticles were deposited onto an amorphous carbon-covered copper grid and imaged under a JEOL 2010 microscope at an accelerating voltage bar of 200 kV. like figure 1 As shown, the selenium nanoparticles range from 20-40 nm, with an average size of 30 nm. figure 2 Corresponding to the electron di...

Embodiment 2

[0057] L-glutathione was used as a reducing agent instead of L-cysteine ​​in Example 1, and the preparation method of Example 1 was repeated to obtain similar amorphous selenium nanoparticles. Transmission electron micrographs show that the obtained selenium nanoparticles are basically all in the range of 20-50nm in size, and the average size is about 40nm. The experimental results of the stability investigation of the prepared selenium nanoparticle solution stored in a dry environment at normal temperature show that the selenium sample prepared by the present invention is still stable without precipitation after being placed for 90 days.

Embodiment 3

[0059] Use sodium selenate to replace the sodium selenite of embodiment 1, the reaction temperature of preparation is 25 ℃, other are the same as embodiment 1. The amorphous selenium nanoparticles are prepared, and the transmission electron micrograph shows that basically all the particle diameters of the obtained selenium nanoparticles are in the range of 30-70nm, and the average size is about 40nm. The experimental results of the stability study of the prepared selenium nanoparticle solution stored in a dry environment at room temperature show that the selenium sample prepared in this example is still stable without precipitation and color change after being placed for 60 days, and slightly turbid after 90 days.

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Abstract

The invention relates to selenium nano-particles and a preparation method thereof, in particular to amorphous selenium nano-particles with the grain diameter being 1-300 nm and a preparation method of the selenium nano-particles. The preparation method of the selenium nano-particles includes the steps that selenium combined macromolecules, a selenium source and a reducing agent or an oxidizing agent are subjected to a mixed reaction in a water phase medium, and nano-particles with the grain diameter being 1-300 nm are prepared; the selenium combined macromolecules are selected from water-soluble protein, water-soluble cellulose and water-soluble pectin and a combination of water-soluble protein, water-soluble cellulose and water-soluble pectin. According to the technical scheme, the nano selenium particles can be well stabilized, the nano selenium particles are not easily gathered into micron fine particles or larger selenium particles, and it is guaranteed that the nano selenium particles have good bioavailability and a good biological effect.

Description

technical field [0001] The invention relates to a selenium nanoparticle and a preparation method thereof. Specifically, the invention relates to an amorphous selenium nanoparticle with a particle diameter of 1-300 nm and a preparation method of the selenium nanoparticle. Background technique [0002] Selenium is an essential trace element for humans and animals. The main form of selenium in mammals is in the form of selenoprotein, and the DNA coding codon for selenocysteine ​​is TGA. Selenocysteine ​​has strong nucleophilicity and is a catalytic group that plays a key role in some enzymatic reactions. Other biological effects of selenium include anti-oxidation. [0003] Mammalian cells acquire selenite and selenate from food and water as selenium sources, and selenite is reduced by glutathione-gluredoxin to selenium compounds, which are utilized by the thioredoxin system. However, the toxicity of inorganic selenium compounds such as selenite and selenate is also well known...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B19/02B82Y30/00A61K33/04A61P35/00
CPCC01B19/02A61K33/04C01P2002/76C01P2004/04C01P2004/64C01P2006/22
Inventor 温彩珑
Owner 温彩珑
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