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Three-dimensional microflow control chip containing in-situ poly(butyl methacrylate) preprocess integral column

A butyl methacrylate, microfluidic chip technology, applied in the field of micro-total analysis, can solve the problems of reduced pretreatment efficiency and difficult integration.

Inactive Publication Date: 2009-02-04
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The monolithic solid-phase extraction pretreatment chip can greatly improve the analytical selectivity by selecting adsorbents with different properties, but there are problems such as reduced pretreatment efficiency and difficult integration during the elution process.

Method used

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  • Three-dimensional microflow control chip containing in-situ poly(butyl methacrylate) preprocess integral column
  • Three-dimensional microflow control chip containing in-situ poly(butyl methacrylate) preprocess integral column
  • Three-dimensional microflow control chip containing in-situ poly(butyl methacrylate) preprocess integral column

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Embodiment Construction

[0021] The microfluidic solid phase extraction pretreatment chip that the present invention proposes, its structure is as follows figure 1 As shown, the entire chip is formed by directly sealing the substrate 8 and the cover 7, and the structural dimensions are: length (30mm)×width (20mm)×height (3mm). figure 2 The thickness of the cover slip is 1-2 mm, the length of the solid-phase extraction pretreatment microchannel (A-B monolithic column) in the cover slip is (5-10 mm), and the diameter of the pipeline is 75-200 μm; image 3 The thickness of the middle substrate is 1 mm, and the size of the mixing and reaction microchannel in the substrate is length (10-30 mm)×width (50-200 μm)×depth (50-200 μm).

[0022] For the structure of the cover slip see figure 2 , the cover is equipped with sample inlet 1, reagent inlet 2, waste liquid outlet 3 and solid phase extraction pretreatment microchannel, which is prepared by PDMS integral casting molding method, and the solid phase ext...

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Abstract

The invention pertains to the technology field of micro total analysis, relating to a three-dimensional micro-flow control chip which includes an in-situ polybutyl methacrylate pretreatment integral pole. The polymer butyl methacrylate pretreatment integral pole is prepared by ultraviolet-radiated in-situ polymerization in the micro-channel on the micro-flow control chip; the substrate of the micro-flow chip can adopt glass, silicon, polymethyl methacrylate (PMMA) or poly(dimethylsiloxane) (PDMS), and the like as base materials, and etched with micro-channel networks for fluid mixing and reaction; the cover plate adopts PDMS integral casting method to fabricate the micro-channels of the solid-phase extracting and processing unit, a fluid lead-in / lead-out hole is arranged at the position corresponding to each micro-channel opening of the substrate, and is directly bounded with the substrate, and integration of the sample pretreatment integral pole and the micro-flow control chip micro-pipeline network is realized. The chip has the advantages of easy fabrication, low cost, small sampling quantity, rapid compartment analysis, and is applicable to pretreatment, analysis and test of sophisticated biochemical samples.

Description

Technical field: [0001] The invention belongs to the technical field of micro-total analysis, and relates to a three-dimensional microfluidic chip containing solid-phase extraction monolithic column medium for separating and enriching samples and a preparation method thereof. Background technique: [0002] Micro-total analysis system (μ-TAS, also known as lab-on-a-chip, Lab-on-a-chip) can greatly reduce the cost of reagents due to its characteristics of continuous, integrated, automated and miniaturized analysis processes. Therefore, it has been widely used in the fields of disease diagnosis, biochemical analysis, and clinical testing. Due to the complexity of the substrate and components in the measured sample, the coexistence of matrix effect and various interfering components, the sample pretreatment process is mostly realized outside the microfluidic chip by centrifugation, filtration, separation, etc., which is not conducive to the integration of the micro-analysis syst...

Claims

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Application Information

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IPC IPC(8): G01N1/40G01N35/00G01N33/48
Inventor 徐溢张文品曹强徐平洲曾萍
Owner CHONGQING UNIV
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