Applications of growth hormone release hormone agonist in preparation of anti-vascular calcification drugs

A growth-stimulating hormone, anti-vascular calcification technology, applied in the fields of pharmacology and chemical biology
CN107320718AActive Publication Date: 2017-11-07余红
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
余红
Publication Date
2017-11-07

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Abstract

The present invention discloses a new medical use of a growth hormone release hormone (GHRH) agonist, particularly applications of a growth hormone release hormone agonist in preparation of anti-vascular calcification drugs. According to the present invention, GHRH-A can increase the cAMP level and the protein kinase A (PKA) activity in smooth muscle cells, can decrease the expression and the activity of NAPDH oxidase in smooth muscle cells, can decrease the ROS level in smooth muscle cells, can decrease the expression and the activity of Runx2 in smooth muscle cells, can decrease the expression and the activity of alkaline phosphatase (ALP) in cells, and can decrease the inorganic phosphorus content in blood so as to reduce the calcium deposition and the phosphorus deposition in aorta, reduce the activity of ALP in aorta, and achieve the purposes of treatment or prevention of vascular calcification and arteriosclerosis.
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Description

technical field

[0001] The invention relates to the fields of pharmacology and chemical biology, in particular to the application of growth-stimulating hormone-releasing hormone agonists in the preparation of anti-vascular calcification drugs. Background technique

[0002] Vascular Calcification (VC) is a disease characterized by calcium salt deposition in the intima and media of blood vessels. It is closely related to various diseases such as atherosclerosis, diabetes and chronic kidney disease, and seriously affects the prognosis of these diseases. Early studies believed that arterial calcification is mainly passive calcium and phosphate deposition. However, with the deepening of research, it was found that there is a similarity between the process of arterial calcification and bone mineralization, not just passive calcium salt deposition, but more smooth muscle cells differentiate into osteoblast-like cells in a stressful environment, leading to Ongoing development of ca...

Claims

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