Method for preparing chitosan reinforced bars

A chitosan and rod technology, which is used in medical science, internal bone synthesis, prosthesis and other directions to achieve the effects of superior performance, good biodegradability and high mechanical strength

Inactive Publication Date: 2008-07-23
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology involves making strong plastic that cannot break down easily due to factors like wound healing or surgery procedures such as removing tissue scars during surgeries. By adding small pieces called polyglycolic acids (PGA) into this type of plastic, they become stronger over time without losing their effectiveness when used alone. These tiny particles absorb water molecules inside them while still being safe enough to use safely within human bodies. Additionally, these PGAs have been shown effective at creating pores on the surface where cells form themselves, allowing fluoroscopy agents to pass freely throughout the body's bloodstream instead of relying solely upon physical contact between the patient and an external device. Overall, this new technique allows patients who require long term implants to receive secure stabilized treatment even after undergoing major operations.

Problems solved by technology

This patented technical solution describes how current methods of treating fractured parts can lead to complications due to poor compatibility between metals or other substances found inside them. These issues require new ways to develop effective medical device designs made from natural sources like chitins instead of artificial ones.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 0.06g of short polylactic acid fibers (2mm) and add them to 100mL of 2% (v / v) acetic acid solution and stir to disperse the fibers. Add 3g of chitosan powder to the solution, stir evenly, and let stand for defoaming. Take a small amount of chitosan solution and inject it into the mold, first form an inner film in 3% (w / v) sodium hydroxide coagulation solution, then fill the mold with the solution, then put it into the sodium hydroxide coagulation solution and remove the mold . After 20 hours, soak the chitosan gel rod in distilled water until it becomes neutral, and dry it in a vacuum oven at 30°C to obtain a transparent, slightly yellow polylactic acid short fiber-reinforced chitosan rod. Test the flexural strength and flexural modulus of chitosan rods, the results are shown in Table 1.

Embodiment 2

[0018] Weigh 1.20g of short polylactic acid fibers (23mm) and add them to 100mL of 2% (v / v) acetic acid solution and stir to disperse the fibers. Put 6g of chitosan powder into the solution, stir evenly, and let stand for defoaming. Take a small amount of chitosan solution and inject it into the mold, first form an inner film in 10% (w / v) sodium hydroxide coagulation solution, then fill the mold with the solution, then put it into the sodium hydroxide coagulation solution and remove the mold . After 8 hours, put the chitosan gel rod into distilled water and soak until it becomes neutral, and put it into a vacuum oven at 80° C. for drying to obtain a polylactic acid short fiber-reinforced chitosan rod. The flexural strength and flexural modulus are listed in Table 1.

Embodiment 3

[0020] Weigh 0.12g of short polylactic acid fibers (2mm) and add them to 100mL of 2% (v / v) acetic acid solution and stir to disperse the fibers. Put 6g of chitosan powder into the solution, stir evenly, and let stand for defoaming. Take a small amount of chitosan solution and inject it into the mold, first form an inner film in 10% (w / v) sodium hydroxide coagulation solution, then fill the mold with the solution, then put it into the sodium hydroxide coagulation solution and remove the mold . After 8 hours, put the chitosan gel rod into distilled water and soak until neutral, then put it into a vacuum oven at 60°C and dry it to obtain the polylactic acid short fiber reinforced chitosan rod. The flexural strength and flexural modulus are listed in Table 1.

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PUM

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Abstract

The invention relates to a preparation method of a biological composite, in particular to a preparation method of chitosan reinforced rod, providing a preparation method of chitosan reinforced rod which has favorable mechanical property and is biodegradable, absorbable and can be taken as bone fracture internal fixation. The preparation method is characterized in that: chitosan powder is added into the acetic acid solution in which poly-lactic acid short fiber is dispersed, the solution is agitated to form a chitosan/acetic acid solution; the chitosan/acetic acid solution is smeared on the inner wall of a mould, the mould is immersed and precipitated into sodium hydroxide solution, and then chitosan membrane taken as a mould board for in situ precipitation is obtained; the mould is filled with the chitosan/acetic acid solution, and then the mould are taken off in the sodium hydroxide solution, while the chitosan/acetic acid solution is immersed into the sodium hydroxide solution until the whole chitosan gel rod is formed; the chitosan gel rod is immersed into distilled water till the water is neutral, and then the rod is dried, at last the poly-lactic acid short fiber reinforced transparent yellowish chitosan rod is obtained.

Description

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Claims

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Application Information

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Owner XIAMEN UNIV
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