Method for preparing bionic laminar articular cartilage/bone compound implant

Abstract

The invention relates to a method for preparing bionic laminated cartilage / bone element, wherein it comprises preparing porous same heterogenous bone or different bone elements; preparing artificial cartilage and laminated cartilage / bone composite. The invention processes the bone into needed size and shape, to be washed and immunity treatment, to be put at the bottom of mould; then at positive and passive pressures, pouring the polyvinyl alcohol / biological active component preformed element and polyvinyl alcohol / lubricant molecule preformed element into mould; flattening the surface and compressing; freezing and fusing, shaping. The inventive product has surface layer as abrasion-resistant lubricant layer, middle layer as force layer, and bottom layer as biological active cartilage / bone combine layer, to meet biological physica property and physiological function.

Description

technical field

[0001] The invention belongs to the technical field of biomedical materials or biocomposite materials, and in particular provides a method for preparing a bionic layered articular cartilage / bone composite implant. Background technique

[0002] The repair and replacement of cartilage tissue is a common operation in clinical surgery. At present, the clinical treatment of articular cartilage mainly adopts autologous or allogeneic cartilage transplantation and artificial cartilage replacement. At present, the artificial cartilage materials that have been studied more mainly include metal-ultra-high molecular weight polyethylene anti-friction joint prosthesis, silicone rubber, polyurethane joint cushion material, polyvinyl alcohol hydrogel, etc. Although these cartilage prostheses can replace cartilage to a certain extent, they still have disadvantages such as easy wear and loosening, poor interface lubrication, and lack of biological activity. The physiological ...