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Polymer blends as biodegradable matrices for preparing biocomposites

a polymer blend and biodegradable technology, applied in the field of polymer matrices, can solve the problems of poor film-forming properties, less useful aromatic diols (e.g. bis-phenols) for these purposes, and less useful aromatic diacids (like phthalic acids, etc.) for these purposes, and achieves high enzyme-catalyzed biodegradation rates and high plasticity

Inactive Publication Date: 2008-06-03
SURMODICS INC
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  • Claims
  • Application Information

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Benefits of technology

This patent describes an innovative type of material made from natural components that can be used as a matrix for wound healing devices. It has strong flexibility and can hold large amounts of active ingredients such as proteins without losing them over time. Additionally, it can easily dissolve in commonly available solvents and allow the embedded enzymes to slowly release while maintaining their activity levels. Overall, this material provides a promising solution for creating effective wound care products.

Problems solved by technology

The technical problem addressed in this patent text needs to be identified by a senior R&D personnel.

Method used

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  • Polymer blends as biodegradable matrices for preparing biocomposites
  • Polymer blends as biodegradable matrices for preparing biocomposites
  • Polymer blends as biodegradable matrices for preparing biocomposites

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[0058]A complex of polyvalent bacteriophages directed toward Staphylococcus species, Streptococcus species, E. coli, Proteus species, and Pseudomonas aeruginosa with a titer of 2×106-2×107 plaque-forming units, was prepared and used as bioactive substance for this study. Bacteriophage were prepared as a lyophilized dry powder as follows: bacteriophages suspended in an aqueous sucrose-gelatin mixture were lyophilized, resulting in a dry mass that was ground into fine powder. In this process, 50 mg of dry preparation corresponds to 1 ml of liquid bacteriophage with a titer of 2×106-2×107. None of the individual components of bioactive composites (polymer, organic solvent, alpha-chymotrypsin, lipase) affected bacteriophages activity—100% of starting activity was retained in all cases.

[0059]A bioactive film was prepared as follows: A fine suspension of dry bacteriophage in a polymer solution with an appropriate solvent was cast on a glass surface and dried to constant weight. A composit...

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Abstract

The present invention provides bioerodable constructs for controlled release of bioactive materials. In a preferred mode, the constructs may be utilized adjacent to a biological surface. The constructs are based on a blend of two or more poly(ester-amide) polymers (PEA). Such polymers may be prepared by polymerization of a diol (D), a dicarboxylic acid (C) and an alpha-amino acid (A) through ester and amide links in the form (DACA)n. An example of a (DACA)n polymer is shown below in formula II. Suitable amino acids include any natural or synthetic alpha-amino acid, preferably neutral amino acids.

Description

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Claims

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Application Information

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Owner SURMODICS INC
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