Material increase manufacturing method of multi-scale biomimetic artificial bone support

A technology of additive manufacturing and artificial bone, applied in the field of additive manufacturing, can solve the problems of secondary disinfection and preservation of microspheres, and the difficulty of quantitative control of pore size and porosity, so as to achieve a wide range of materials and reduce clinical application. Accurate and controllable effect of cost and dosage

Active Publication Date: 2015-08-12
西安点云生物科技有限公司
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Problems solved by technology

However, the pore size and porosity of the porous structure formed by the accumulation of microspheres are difficult to quantitatively control, and the microspheres in the

Method used

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  • Material increase manufacturing method of multi-scale biomimetic artificial bone support
  • Material increase manufacturing method of multi-scale biomimetic artificial bone support
  • Material increase manufacturing method of multi-scale biomimetic artificial bone support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The inorganic and organic materials of human bones are mainly hydroxyapatite and collagen, and the realization of additive manufacturing of such degradable composite materials can lay a technical foundation for bone tissue repair.

[0027] 1) Using 30% by mass of collagen and 70% by mass of nano-hydroxyapatite as the artificial bone matrix material, mixed with 6 times deionized water, and freeze-dried to obtain a homogeneous powder;

[0028] 2) Mix the powder obtained in step 1 with 5 times deionized water to obtain a slurry with a viscosity of 320,000 centipoise, and vacuum exhaust;

[0029] 3) Extrude the liquid slurry obtained in step 2 by quantitative extrusion with a screw pump;

[0030] 4) Using the XYZ motion device, according to the three-dimensional geometric model of the bone defect obtained from the CT scan, the pore structure parameters inside the geometric model are designed through a computer program: square pores, the hole side length is 0.8mm, and the po...

Embodiment 2

[0032] Adding bone morphogenic protein (Bone Morphogenetic Protein, BMP) to bone matrix materials can better promote bone repair.

[0033] 1) Using 8% by mass of BMP, 32% by mass of collagen and 60% by mass of nano-calcium-deficient hydroxyapatite as the artificial bone matrix material, mixed with 8 times deionized water, and freeze-dried to obtain a uniform Quality powder;

[0034] 2) Mix the powder obtained in step 1 with 6 times of deionized water to obtain a slurry with a viscosity of 250,000 centipoise, and vacuum exhaust;

[0035] 3) Extrude the liquid slurry obtained in step 2 by quantitative extrusion with a screw pump;

[0036] 4) Using the XYZ motion device, according to the three-dimensional geometric model of the bone defect obtained from the CT scan, the internal pore structure parameters of the geometric model were designed through computer programs: hexagonal honeycomb pores, the length of the hole side is 1mm, and the porosity is 80%. The trajectory of the ex...

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Abstract

The invention discloses a material increase manufacturing method of a multi-scale biomimetic artificial bone support. The material increase manufacturing method comprises blending a biopolymer material and a bioceramic material, blending the mixture and deionized water or an organic solvent to obtain uniform slurry, carrying out freeze drying to obtain uniform powder, blending the uniform powder and deionized water or an organic solvent, carrying out vacuum exhaust, carrying out quantitative extrusion by a screw pump, by a XYZ motion device, designing internal aperture shapes, sizes and porosity of a geometric model by computer program according to a bone defect 3D geometric model obtained by CT scanning, and carrying out material increase manufacture under control of an extruded material motion locus. Through use of a degradable biological compound material, human autologous tissue finally replaces bone defect positions so that human lifelong growth requirements are satisfied. The needed biomaterial is quantificationally extruded by the screw pump so that use amount can be accurately controlled and an artificial bone clinical application cost is substantially reduced. The material increase manufacturing method has the advantages of accurate printing material use amount, wide material application range, accurate and controllable aperture structure, and free formation of a macroscopic geometric shape.

Description

technical field [0001] The invention relates to an additive manufacturing method, in particular to a multi-scale bionic artificial bone scaffold additive manufacturing method in the field of biomedical bone tissue engineering. Background technique [0002] Healthy survival is the first priority of human development. At present, the extreme shortage of hard tissue and bone grafts has caused a large number of patients to become disabled or even die. Therefore, there is an urgent need to develop biodegradable artificial bone scaffolds with biomimetic features in terms of material composition, microstructure, and geometric shape, which has become the golden rule for large-segment bone replacement. Artificial bone refers to a human bone substitute or fracture fixation material made of artificial materials. Artificial bone is a substitute for traditional bone repair materials. It has good mechanical strength and physiological activity, and can greatly reduce the pain of patients. ...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/10A61L27/22
Inventor 曾庆丰张鑫
Owner 西安点云生物科技有限公司
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