Thiol-aldehyde group cross-linked hydrogel material, preparation method and applications thereof

A cross-linked hydrogel and aldehyde-based technology, which is applied in pharmaceutical formulations, medical preparations of non-active ingredients, medical science, etc., can solve problems such as insufficient clinical operation time, plugging of pipette tips, and gel displacement.
CN110128682AActive Publication Date: 2019-08-16EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2019-08-16

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Abstract

The invention relates to a thiol-aldehyde group cross-linked hydrogel material, a preparation method and applications thereof. The preparation method comprises: dissolving a component A thiol-containing polymer derivative in a biocompatible medium to obtain a solution A; dissolving a component B aldehyde group-containing polymer derivative in a biocompatible medium to obtain a solution B; and mixing with the solution A and the solution B to obtain the hydrogel, wherein the hydrogel has plasticity at the initial stage of cross-linking, can form a removable hydrogel system at the later stage ofcross-linking, and can form an interpenetrating network hydrogel system with enhanced mechanical property, a component C and / or a component D can be added to the hydrogel precursor solution, the component C is a double bond-containing substance or an amino-containing substance or a substance containing a double bond and amino, and the component D is a tissue repairing beneficial ingredient. The invention further provides a kit for preparing the hydrogel, applications of the hydrogel in tissue engineering and regenerative medicine, 3D cell culture, 3D printing, and applications of the hydrogelas cell carriers, protein carriers or drug carriers.
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Description

technical field

[0001] The invention relates to a hydrogel material, in particular to a mercapto-aldehyde group crosslinked hydrogel material and a preparation method and application thereof, belonging to the technical field of biomaterials. Background technique

[0002] Hydrogel is a kind of highly water-containing polymer material with a three-dimensional network cross-linked structure. Due to its excellent biocompatibility, degradability and certain mechanical strength, it has been used as a scaffold material in the field of tissue engineering and has been applied in the skin. , Cartilage, bone, myocardium, corneal repair, etc. have made important breakthroughs. In addition, it also has unique advantages in clinical wound treatment, such as hemostasis, protection, isolation, and repair. Currently, hydrogels are applied in clinical operations in two ways: preformed hydrogels and in-situ formed hydrogels. Preformed hydrogels refer to gels that have been cross-linked into a ...

Claims

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