126 results about "Cross linked hydrogels" patented technology

The invention belongs to the technical field of probiotic preparations, and particularly relates to bifidobacterium longum subsp. Longum and application thereof in resisting helicobacter pylori. The bifidobacterium longum subsp. Longum provided by the invention has a good inhibition effect on helicobacter pylori. Furthermore, the bifidobacterium longum subsp. Longum is effectively embedded through enzyme cross-linking and ionic cross-linking by adopting the bifidobacterium longum subsp. Longum, so that not only can the embedding rate of the strain be improved, but also the survival rate of the strain can be remarkably improved in a digestion environment, and the efficient planting of the strain is realized; particularly, the effect of resisting helicobacter pylori infection can be obviously improved. Therefore, the invention has important practical significance on prevention and treatment of helicobacter pylori infection, and can also provide a technical basis for application of anti-helicobacter pylori functional products in the future.

The invention relates to the technical field of preparation of medical supplies, in particular to a surgical membrane and a preparation process. During specific use, firstly, a polyurethane base membrane is selected and subjected to plasma treatment; spraying a nano SiO2 dispersion liquid containing a photoinitiator on the surface of the treated polyurethane base film, and then performing ultraviolet patterning irradiation to form a micro-bulge structure to obtain a base material layer; projecting the colloidal fluid to a temperature gradient mask through a digital micromirror device, so that the colloidal fluid is subjected to regional thermal polymerization on the substrate layer to form an intelligent adhesive layer with viscosity gradient; by adopting an aerosol jet printing technology, super absorbent fibers and polyvinyl alcohol-borax dynamic crosslinking hydrogel are co-deposited to form a drainage layer, so that the technical problems that a surgical membrane prepared by a surgical membrane preparation mode in the prior art is inflexible in adhesion and poor in surface structure performance, and a preparation process is difficult to accurately control are solved.

The invention discloses a hydrogel-acellular matrix composite patch containing functionalized extracellular vesicles and a preparation method of the hydrogel-acellular matrix composite patch. The composite patch comprises a hydrogel layer and an acellular pericardium matrix material layer, and an extracellular vesicle-macrophage membrane fusion body (EV-MM) is entrapped in the cross-linked hydrogel. From two aspects of improving the targeting of EVs to the cardiac infarction part and enhancing the retention of the EVs at the cardiac infarction part, the distribution condition of the EVs at the cardiac infarction part is improved, so that the action efficiency of the EVs is improved, and the treatment effect is improved.

The invention provides a novel recombinant III type collagen and a PEG (Polyethylene Glycol) cross-linked hydrogel thereof. The invention also provides an application of the PEG cross-linked hydrogel as a tissue filling agent.

The invention relates to the technical field of biomedicine, in particular to stem cell exosome-loaded bi-crosslinked hydrogel as well as preparation and application thereof, and the bi-crosslinked hydrogel comprises the following components in parts by weight: 50-90 parts of a matrix polymer; 0.1 to 5 parts of an active load; 1 to 10 parts of cyclodextrin; 5 to 20 parts of modified chitosan; 0.01 to 1 part of a photoinitiator; and 0.01 to 0.5 part of growth factors. Through double-network design of physical / chemical primary cross-linking and photo-initiation secondary cross-linking, the bottleneck that the mechanical property and the machinability of the traditional single cross-linking hydrogel are difficult to consider at the same time is overcome; meanwhile, the human umbilical vein endothelial cell exosome is introduced, and efficient loading, uniform dispersion and degradation coupling slow release of the exosome are realized by virtue of beta-cyclodextrin inclusion and a double-crosslinking network. Therefore, the problems of mechanics, degradation, cross-linking speed or tissue adhesion of cross-linked hydrogel in the prior art are solved.

In some aspects, the present disclosure provides systems for forming hydrogels that comprise (i) a reactive multi-arm polymer that comprises three or more polymer arms linked to a core region, each arm comprising a polyether segment and a reactive moiety comprising a cyclic imide carboxy-C1-C5-alkyl ester end group or each arm comprising a polyether segment and a reactive moiety comprising a C2-C6-isocyanoalkyl end group and (ii) a polyamino compound comprising at least two amino (-NH2) groups, wherein the reactive multi-arm polymer and the polyamino compound react to form a crosslinked hydrogel that does not contain ester groups and has long-term stability in vivo. In some aspects, the present disclosure provides methods of treatment using such systems and hydrolysis-resistant crosslinked hydrogels formed from such systems.

The invention is applicable to the technical field of hydrogel, and provides dynamic cross-linked hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: cross-linking oxidized dextran and carboxymethyl chitosan containing phenylboronic acid modification groups; glucanase is added before the hydrogel is formed, and calcium peroxide nanoparticles coated with polydopamine are introduced; wherein the mass concentration of the oxidized dextran is 2-10% w / v, the mass concentration of the carboxymethyl chitosan containing the phenylboronic acid modified group is 2% w / v, the concentration of the glucanase is 10-100 U, and the concentration of the calcium peroxide nanoparticles coated with the polydopamine is 0.1-1% w / v. The hydrogel disclosed by the invention shows good cell compatibility, angiogenesis promoting capability and bioactivity for promoting dental pulp regeneration in multiple in-vitro and in-vivo experiments, is suitable for tissue engineering fields such as dental pulp injury repair and the like, and effectively solves the technical problem that conventional hydrogel is insufficient in cell survival support in three-dimensional culture and the like.

In some aspects, the present disclosure pertains to a method of forming radiopaque crosslinked hydrogel particles comprising (a) mixing a reactive multi-arm polymer comprising a plurality of cyclic imide ester groups, a reactive multifunctional compound comprising a plurality of amino groups, and a radiocontrast agent under conditions in which a pH environment surrounding the reactive multi-arm polymer, the reactive multifunctional compound and the radiocontrast agent increases from an acidic pH to a basic pH, thereby forming a radiopaque hydrogel and (b) subjecting the hydrogel to a particle size reduction process, thereby forming the radiopaque crosslinked hydrogel particles. Other aspects of the present disclosure pertain to radiopaque crosslinked hydrogel particles formed from such methods, suspensions of such radiopaque crosslinked hydrogel particles, and medical supplies that contain such radiopaque crosslinked hydrogel particles.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention relates to the technical field of fire-fighting materials, in particular to a fire-retardant thermosensitive self-crosslinking hydrogel fire extinguishing agent and a preparation method thereof. In order to solve the technical problems that an existing hydrogel fire extinguishing agent is limited in fire retardance effect, and especially for a high-temperature fire source, the existing hydrogel fire extinguishing agent is difficult to achieve a good fire retardance effect, the invention discloses a fire retardance type thermosensitive self-crosslinking hydrogel fire extinguishing agent which comprises the following components in percentage by mass: 0.05-1% of aryl sulfonylated carboxymethyl cellulose, 0.05-1% of a cross-linking agent, 0.05-1% of a cross-linking agent and the balance of water. 0.1%-2% of a first thickening agent; 0.1%-2% of a second thickening agent; 0.3 to 3 percent of a surfactant; 0.5-5% of a first flame retardant; 0.5 to 5% of a second flame retardant; and the other component is a solvent. The fire-retardant thermosensitive self-crosslinking hydrogel fire extinguishing agent can be used for rapid extinguishing and after-combustion inhibition of a high-temperature (less than or equal to 700 DEG C) fire source. And a good fire retardant effect is achieved.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

There is provided a method of producing a hydrogel. A first polymer functionalized with a homocysteine thiolactone of formula I is reacted to open the ring and obtain a pendant thiol group, wherein any three of the R2 are H, and the remaining R2 is selected from H, C1-C4 branched or linear alkyl, methoxy, ethoxy, and halogen;. (I) The pendant thiol group of the first polymer are then crosslinked with a pendant vinyl group on a second polymer in the presence of a gel former to obtain the hydrogel.

The invention discloses a preparation method and application of bamboo nanocellulose and bi-crosslinking hydrogel. The preparation method of the hydrogel comprises the following steps: (1) dispersing the bamboo nanocellulose; (2) preparing a lignin-Fe solution; and (3) preparation of the bi-crosslinked hydrogel: adding the bamboo nanocellulose suspension and acrylic acid into water, then adding ammonium persulfate and N, N '-methylene bisacrylamide, finally adding the lignin-Fe solution to obtain a precursor solution, and pouring the precursor solution into a mold to obtain the bi-crosslinked hydrogel. The moso bamboo is used as a raw material, cellulose is extracted from the plant which is extremely high in carbon sequestration capacity and rapid in production and then is processed into nano cellulose, a novel utilization way is provided for the moso bamboo, and the hydrogel prepared from the moso bamboo is good in environment friendliness, green, natural and non-toxic, can be in direct contact with skin, and has a good application prospect. And the application and development of the material in the fields of environmental protection, biomedical treatment, electronic skin, wearable sensors and the like are facilitated.

In some aspects, the present disclosure provides systems for forming hydrogels that comprise (i) a reactive multi-arm polymer that comprises three or more polymer arms linked to a core region, each arm comprising a polyether segment and a reactive moiety comprising a cyclic imide carboxy-C1-C6-alkyl ester end group or each arm comprising a polyether segment and a reactive moiety comprising a C2-C6-isocyanoalkyl end group and (ii) a polyamino compound comprising at least two amino (—NH2) groups, wherein the reactive multi-arm polymer and the polyamino compound react to form a crosslinked hydrogel that does not contain ester groups and has long-term stability in vivo. In some aspects, the present disclosure provides methods of treatment using such systems and hydrolysis-resistant crosslinked hydrogels formed from such systems.

This disclosure provides a wearable electrochemical biosensor for detecting at least one target analyte in interstitial fluid of a subject, comprising, a microneedle array comprising a highly- crosslinked hydrogel polymer; at least one electrochemical chip comprising at least one transducer surface configured for generating a signal in the presence of the at least one target analyte; and a low crosslinked hydrogel polymer, wherein the low crosslinked hydrogel polymer is configured to couple the microneedle array with the at least one transducer surface of the electrochemical chip. Methods of making and use thereof are also disclosed.

The invention relates to the technical field of hydrogel, in particular to photocuring 3D printing ink and a preparation method thereof, synchronous curing bi-crosslinking hydrogel and application thereof. According to the invention, based on the characteristic that an initiator (persulfate) commonly used in a hydrogel preparation process has strong oxidizing property and can react with reducing metal ions to generate free radicals, Fe < 2 + > released by a cationic photoinitiator containing Fe < 2 + > in ultraviolet light reacts with persulfate to generate Fe < 3 + > and free radicals; the preparation of the water-soluble anionic polymer and water-soluble vinyl monomer double-network cross-linked hydrogel is synchronously realized. According to the invention, the problems of insufficient conductivity, stretchability and flexibility of hydrogel prepared by utilizing photocuring 3D printing are solved.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

In certain embodiments, the present disclosure provides medical graft devices having covalently crosslinked matrix protein hydrogel coatings. In some forms, such coatings are configured to reduce the formation of adhesions upon implantation.

The application relates to the technical field of medical materials, and discloses a functionalized hydrogel for treating atopic dermatitis and a preparation method and application thereof, the preparation method comprising the following steps: taking g-C3N4 powder as raw material to prepare C3N4 gel with a three-dimensional network structure; taking g-C3N4 powder and CDs powder as raw material, adding a matrix solution, and uniformly ultrasonically dispersing; adding a crosslinking agent solution to make the solution fully undergo crosslinking reaction to prepare a CDs / g-C3N4 crosslinking solution; pouring the above-mentioned CDs / g-C3N4 crosslinking solution into the above-mentioned C3N4 gel, standing for gelation, forming a functionalized modified carbon nitride gel three-dimensional network structure, and freeze-drying to obtain a functionalized three-dimensional crosslinking hydrogel. The functionalized three-dimensional crosslinking hydrogel prepared by the application has the advantages of degradability and the ability to penetrate through an intact skin barrier; and can be used for treating atopic dermatitis.

According to the hydrogel material disclosed by the invention, the gelatin / gallic acid conjugate with a specific concentration is taken as a base material, and the base material is cross-linked by utilizing a horse radish peroxidase / hydrogen peroxide combined enzyme catalysis system, so that an additional photo-thermal response material does not need to be added in the gelling process of the hydrogel; in the cross-linking process, the hydrogel serves as a cross-linked structure for forming the interior of the hydrogel and shows excellent photo-thermal responsiveness, and the hydrogel can respond to photo-thermal temperature rise to improve the self deformability, so that irregular wounds are better covered; therefore, the invention provides a hydrogel material which has good biological safety, oxidation resistance and bacteriostasis and can be used for wound injury repair.

A bioerodible crosslinked hydrogel based on a multi-arm polyoxazoline having a cage-like silicon-oxygen core is provided. In some aspects, the disclosure relates to reactive multi-arm polymers having a silicon-oxygen cage core and a plurality of polyoxazoline-containing arms extending from the core, the polyoxazoline-containing arms comprising a first end covalently bonded to the silicon-oxygen cage core and a second end comprising a moiety comprising a reactive end group. In other aspects, the disclosure relates to systems comprising such reactive multi-arm polymers and multifunctional compounds comprising functional groups reactive with the reactive end groups of the reactive multi-arm polymers. Other aspects relate to medical hydrogels formed by crosslinking such reactive multi-arm polymers with such multifunctional compounds, and to methods of treatment comprising administering to a subject a mixture comprising such reactive multi-arm polymers together with such multifunctional compounds.

The invention discloses a core amino acid sequence for driving any recombinant protein to be self-assembled into supramolecular hydrogel and application of the core amino acid sequence, and aims to solve the problems of complex synthesis, toxic residue, insufficient biocompatibility, difficulty in performance regulation and control and the like of the traditional chemical crosslinking hydrogel. The whole length of Ure2 (1-19) to Ure2 (1-71) and any truncated body and mutant are covered, and the shortest sequence Ure2 (1-19) has efficient driving self-assembly. The core amino acid sequence is fused to any recombinant protein, the obtained fusion protein can form nanofiber-shaped self-assembly aggregation when the concentration is lower than 1 mg / mL, and can form supramolecular hydrogel with the characteristics of shear thinning effect, injectability and the like when the concentration is greater than or equal to 1 mg / mL, and the formation of the hydrogel does not need any additional artificial interference. The preparation can be finished only by standing for a period of time.

The application provides an antibacterial and anti-inflammatory drug controllable release hydrogel and a preparation method and application thereof, solves the problems of complex preparation process of photo-induced imine crosslinking hydrogel and lack of antibacterial and anti-inflammatory functions, and provides an effective way for treating chronic refractory wounds. The photo-crosslinking hydrogel designed in the application uses an amino-modified polymer derivative as a crosslinking matrix, and uses a double-branched small molecule compound as a crosslinking agent. The crosslinking system is simple to prepare, and can be quickly gelled under 395nm ultraviolet light. By further introducing a double-branched photo-crosslinking agent-antibacterial drug co-carrier and an anti-inflammatory drug slow-release particle into the above crosslinking system, the photo-crosslinking hydrogel of the application exhibits two drug release mechanisms of burst release of antibacterial drugs and slow release of anti-inflammatory drugs, thereby effectively solving the problems of bacterial infection in the early stage and chronic inflammation in the middle stage in the treatment process of chronic refractory wounds.

The present invention provides a preparation method for a nano-drug composite dynamic cross-linked hydrogel with curcumin / nitric oxide / photothermal synergistic antibacterial effect. The present invention uses copper salt to chelate curcumin to form first nanoparticles, and then uses polydopamine to coat the first nanoparticles to form nano-drug P Cur Sodium nitroprusside and sodium phytate were used as raw materials and nano-coprecipitation method was used to prepare second nanoparticles; polydopamine was then used to coat the second nanoparticles to prepare a core-shell structure nano drug P NO ; The nano drug P cur and P NO The nanocomposite hydrogel is mixed evenly with carboxymethyl chitosan and oxidized hyaluronic acid to form a nanocomposite dynamically cross-linked hydrogel. In addition to its significant antibacterial properties, the nanocomposite hydrogel of the present invention also has significant advantages such as high antibacterial efficacy, good biosafety, convenient preparation, and low cost. The present invention also combines drug, photothermal, and gas therapy in a single device, facilitating synergistic and precise bacterial elimination.

This invention relates to a composition for promoting hair growth, comprising a dynamically cross-linked hydrogel loaded with dermal papilla cells. The dynamically cross-linked hydrogel includes adamantane-grafted hyaluronic acid, gelatin, and cyclodextrin modified with cross-linking groups. A three-dimensional network of the dynamic hydrogel is formed through host-guest interactions and the cross-linking of the cross-linking groups. The invention also provides a method for preparing the composition for promoting hair growth, comprising mixing adamantane-grafted hyaluronic acid and cyclodextrin modified with cross-linking groups to obtain a hydrogel prepolymer; adding a dermal papilla cell suspension to the hydrogel prepolymer to initiate a cross-linking reaction of the cross-linking groups to form a dynamically cross-linked hydrogel loaded with dermal papilla cells. The composition can be directly delivered to the depth of hair follicles in the scalp via mesotherapy injection to activate dormant hair follicles from the root, promote new hair growth, and thicken existing hair. The hair regeneration effect is rapid and long-lasting.

A method for ultra-hydrophilic surface treatment of a polymer fiber substrate according to the present invention comprises the steps of: forming a thermosetting coating layer on the surface of a polymer substrate; forming a carboxylate group (—COO—) on the surface of the thermosetting coating layer; forming an amide bond (—CONH—) between the thermosetting coating layer and hydrogel monomers; and forming a hydrophilic polymer layer by crosslinking the hydrogel monomers.

The invention relates to a composition comprising a cell-free lipoaspirate-derived preparation comprising a lipid fraction and / or an aqueous fraction of a lipoaspirate and at least one biodegradable crosslinked hydrogel. The invention further relates to a device and a kit comprising the composition. The composition, the device and the kit can be generally applied for aesthetic treatment of soft-tissue loss or deficit.

This invention discloses a ternary crosslinked gel electrolyte for zinc-ion batteries, its preparation, and its application. A ternary crosslinked hydrogel is obtained by crosslinking and polymerizing three polymer raw materials—polyacrylamide, a hydroxyl-rich polysaccharide derivative, and a carboxylate-containing polyanionic natural polymer—under thermal initiation conditions. The ternary crosslinked gel electrolyte prepared by this invention has a hierarchical structure with a three-layer crosslinked polymer network, providing excellent compression and resilience performance. Furthermore, the electrostatic attraction between the electrolyte and ions guides uniform zinc deposition, enabling it to maintain electrochemical performance under long-term charge-discharge cycles in ion batteries. It offers advantages such as high safety and low cost, and has significant application prospects in batteries.

The present application relates to a kind of polyamide aerogel film with coordination-covalent double crosslinking network structure and its preparation method and application, with carboxyl-containing diamine, carboxyl-free diamine, diacyl chloride and blocking agent as raw material, solution polymerization is carried out in the presence of organic base, and the polyamide oligomer solution containing polymerizable double bond in end group is obtained;The purified and dried polyamide oligomer is dissolved in aqueous solution containing organic base, and metal salt is added to form coordination crosslinking hydrogel film, and double crosslinking network is constructed by initiating end group double bond polymerization by ultraviolet irradiation, and finally freeze-dried to obtain polyamide aerogel film.The polyamide aerogel film of the present application has high porosity, excellent flexibility and mechanical stability, can efficiently and selectively adsorb heavy metal ions in water body, and can be regenerated efficiently and recycled multiple times by mild acid desorption-alkali activation combined regeneration process, aiming at providing a kind of high-performance, low-cost and sustainable solution for water treatment and environmental remediation field.