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A method for additive manufacturing of multi-scale biomimetic artificial bone scaffolds

A technology of additive manufacturing and artificial bone, applied in the field of additive manufacturing, which can solve the problems of difficult quantitative control of pore size and porosity, difficulty in secondary disinfection and storage of microspheres, etc., to achieve a wide range of materials and reduce clinical application. Accurate effect of cost and dosage

Active Publication Date: 2017-06-16
西安点云生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the pore size and porosity of the porous structure formed by the accumulation of microspheres are difficult to quantitatively control, and the microspheres in the closed geometric structure are also difficult to take out through the pores between the microspheres. There are also difficulties in secondary disinfection and preservation

Method used

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  • A method for additive manufacturing of multi-scale biomimetic artificial bone scaffolds
  • A method for additive manufacturing of multi-scale biomimetic artificial bone scaffolds
  • A method for additive manufacturing of multi-scale biomimetic artificial bone scaffolds

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Experimental program
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Effect test

Embodiment 1

[0026] The inorganic and organic materials of human bones are mainly hydroxyapatite and collagen, and the realization of additive manufacturing of such degradable composite materials can lay a technical foundation for bone tissue repair.

[0027] 1) Using 30% by mass of collagen and 70% by mass of nano-hydroxyapatite as the artificial bone matrix material, mixed with 6 times deionized water, and freeze-dried to obtain a homogeneous powder;

[0028] 2) Mix the powder obtained in step 1 with 5 times deionized water to obtain a slurry with a viscosity of 320,000 centipoise, and vacuum exhaust;

[0029] 3) Extrude the liquid slurry obtained in step 2 by quantitative extrusion with a screw pump;

[0030] 4) Using the XYZ motion device, according to the three-dimensional geometric model of the bone defect obtained from the CT scan, the pore structure parameters inside the geometric model are designed through a computer program: square pores, the hole side length is 0.8mm, and the po...

Embodiment 2

[0032] Adding bone morphogenic protein (Bone Morphogenetic Protein, BMP) to bone matrix materials can better promote bone repair.

[0033] 1) Using 8% by mass of BMP, 32% by mass of collagen and 60% by mass of nano-calcium-deficient hydroxyapatite as the artificial bone matrix material, mixed with 8 times deionized water, and freeze-dried to obtain a uniform Quality powder;

[0034] 2) Mix the powder obtained in step 1 with 6 times of deionized water to obtain a slurry with a viscosity of 250,000 centipoise, and vacuum exhaust;

[0035] 3) Extrude the liquid slurry obtained in step 2 by quantitative extrusion with a screw pump;

[0036] 4) Using the XYZ motion device, according to the three-dimensional geometric model of the bone defect obtained from the CT scan, the internal pore structure parameters of the geometric model were designed through computer programs: hexagonal honeycomb pores, the length of the hole side is 1mm, and the porosity is 80%. The trajectory of the ex...

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Abstract

A multi-scale biomimetic artificial bone scaffold additive manufacturing method, mixing biopolymer materials and bioceramic materials with deionized water or organic solvents to form a uniform slurry, then freeze-drying to obtain a homogeneous powder, and then Mix and stir with deionized water or organic solvent, after vacuum exhaust, quantitatively extrude through screw pump, use XYZ movement device, according to the three-dimensional geometric model of bone defect obtained from CT scan, design the shape of the pores inside the geometric model through computer program , size and porosity, the movement trajectory of the extruded material, to complete the additive manufacturing. Using biodegradable biocomposite materials, the bone defect will eventually be replaced by the human body's own tissue to meet the lifelong growth requirements of the human body. Directly use the screw pump to quantitatively extrude the required biomaterials, the dosage is precise and controllable, and the clinical application cost of artificial bone is significantly reduced. This method has the advantages of accurate printing material dosage, wide application range of materials, precise and adjustable pore structure, and free shaping of macroscopic geometric shape.

Description

technical field [0001] The invention relates to an additive manufacturing method, in particular to a multi-scale bionic artificial bone scaffold additive manufacturing method in the field of biomedical bone tissue engineering. Background technique [0002] Healthy survival is the first priority of human development. At present, the extreme shortage of hard tissue and bone grafts has caused a large number of patients to become disabled or even die. Therefore, there is an urgent need to develop biodegradable artificial bone scaffolds with biomimetic features in terms of material composition, microstructure, and geometric shape, which has become the golden rule for large-segment bone replacement. Artificial bone refers to a human bone substitute or fracture fixation material made of artificial materials. Artificial bone is a substitute for traditional bone repair materials. It has good mechanical strength and physiological activity, and can greatly reduce the pain of patients. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/10A61L27/22
Inventor 曾庆丰张鑫
Owner 西安点云生物科技有限公司
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