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Hydroxyapatite activated titanium alloy surface-layer biological composite material and preparation method thereof

A technology of hydroxyapatite and composite materials, applied in medical science, prosthesis, etc., can solve problems affecting biological activity, nerve and physiological disorders, stress shielding, etc., and achieve improved interface bonding strength, good biocompatibility, Avoid the effect of easy cracking of the interface

Active Publication Date: 2015-08-19
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because the Ti6Al4V alloy sheet is used as the matrix, the elastic modulus of the composite material matrix is ​​relatively high, and it is easy to generate stress shielding between the transplanted body and the surrounding tissues. In addition, the matrix contains Al, V and other elements that are harmful to the human body. A small amount of elements will be released in the medium, causing problems such as cytotoxic reactions and neurological and physiological disorders.
[0005] In conclusion, compounding hydroxyapatite on the surface of titanium and titanium alloys can improve its biocompatibility to a certain extent, but there are still many problems in the above research, such as thin surface composite layer, easy to fall off, stress shielding and toxicity. Elements and other issues, these will affect biological activity, which is not conducive to bone replacement and induced growth of bone cells

Method used

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  • Hydroxyapatite activated titanium alloy surface-layer biological composite material and preparation method thereof
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  • Hydroxyapatite activated titanium alloy surface-layer biological composite material and preparation method thereof

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Experimental program
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Embodiment 1

[0025] (1) Weigh Ti, Nb, and Zr metals with a purity of 99.5%, 99.95%, and 99% and an average particle size of 30 μm according to the mass percentage (wt%) of Ti 60%, Nb 34%, and Zr 6%. Powder; weigh 5.2g according to the mass percentage (wt%) of hydroxyapatite 85% (purity 97%, average particle size 100nm), Ti 15% (purity 99.5%, average particle size 30 μm).

[0026] (2) Put the titanium, niobium and zirconium powder weighed in step (1) into a ball milling tank, the ball milling medium is stainless steel balls, the ball to material ratio is 4:1, after sealing with alcohol, vacuumize to 20Pa, and carry out mechanical alloying for 7 hours Take it out, then place it in a vacuum drying oven and dry it at 40°C to obtain a titanium alloy matrix mixed powder; put the hydroxyapatite powder and titanium powder into a ball mill jar, the ball mill medium is stainless steel balls, and the ball-to-material ratio is 3: 1. After sealing with alcohol, evacuate to 20Pa, mix the powder for 1.5 ...

Embodiment 2

[0031] (1) According to the mass percentage (wt%) of Ti 74%, Nb 13%, and Zr 13.0%, respectively weigh Ti, Nb, and Zr metals with a purity of 99.5%, 99.95%, and 99%, and an average particle size of 25 μm Powder; weigh 3.1g according to the mass percentage (wt%) of hydroxyapatite 90% (purity 97%, average particle size 10 μm), Ti 10% (purity 99.5%, average particle size 25 μm).

[0032] (2) Put the titanium, niobium and zirconium powder weighed in step (1) into a ball milling tank, the ball milling medium is stainless steel balls, the ball to material ratio is 3:1, after sealing with alcohol, vacuumize to 30Pa, and perform mechanical alloying for 6 hours Take it out, then place it in a vacuum drying oven and dry it at 40°C to obtain a titanium alloy matrix mixed powder; put the hydroxyapatite powder and titanium powder into a ball mill jar, the ball mill medium is stainless steel balls, and the ball-to-material ratio is 4: 1. After sealing with alcohol, vacuumize to 30Pa, mix the...

Embodiment 3

[0036] (1) According to the mass percentage (wt%) of Ti 67%, Nb 29%, and Zr 4%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99%, and an average particle size of 45 μm Weigh 4.03g according to the mass percentage (wt%) of hydroxyapatite 95% (purity 97%, average particle size 20nm), Ti 5% (purity 99.5%, average particle size 45μm).

[0037] (2) Put the titanium, niobium and zirconium powder weighed in step (1) into a ball milling tank, the ball milling medium is stainless steel balls, the ball to material ratio is 4:1, after sealing with alcohol, vacuumize to 25Pa, and perform mechanical alloying for 8 hours Take it out, then place it in a vacuum drying oven and dry it at 40°C to obtain a titanium alloy matrix mixed powder; put the hydroxyapatite powder and titanium powder into a ball mill jar, the ball mill medium is stainless steel balls, and the ball-to-material ratio is 3: 1. After sealing with alcohol, vacuumize to 25Pa, mix the powde...

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Abstract

The invention discloses a hydroxyapatite activated titanium alloy surface-layer biological composite material and its preparation method and belongs to the field of biomedical material preparation. The surface-layer biological composite material is characterized in that titanium alloy is used as a matrix, and hydroxyapatite + titanium is a biological active layer. Technological steps are as follows: respectively carrying out mechanical alloying, ball-milling, powder-blending and drying on the titanium alloy matrix powder and the biological active layer powder, respectively placing the dried matrix mixed powder and the dried biological active layer mixed powder to a lower layer and an upper layer of a graphite mould (as shown in the specification), sintering in a spark plasma sintering furnace, and cooling to room temperature to obtain the surface-layer biological composite material. During the sintering process, axial pressure is 30-40 MPa, sintering temperature is 1100-1250 DEG C, and thermal insulation lasts for 10-15 min. In the prepared surface-layer composite material, the composite layer and the matrix are chemically and metallurgically bonded. The interface bonding strength is high, and the problem that a biological ceramic coating is easy to fall off can be solved. The preparation process is clean. The technology is simple and low-cost, and is easy to realize industrial production.

Description

technical field [0001] The invention relates to a hydroxyapatite-activated titanium alloy surface biocomposite material and a preparation method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Biomedical Ti-Nb-Zr alloy is a kind of non-toxic and low elastic modulus titanium alloy. 13Zr, etc., this series of alloys have good mechanical properties, and can be used as a human body implant material for bearing larger parts, but their biological activity is poor. Surface modification is one of the important ways to improve the biological activity of titanium alloys. [0003] At present, there are many studies on surface modification to improve the biological activity of titanium alloys, mainly metal-based ceramic surface biocomposites prepared by methods such as plasma spraying, laser cladding, micro-arc oxidation, and chemical precipitation. It greatly improves the biological activity of titanium and titanium alloys, and ha...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/06B22F7/02B22F3/16C22C1/05
Inventor 何正员张玉勤周荣蒋业华
Owner KUNMING UNIV OF SCI & TECH
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