Preparation method of short-peptide/silicon dioxide/hydroxyapatite porous composite material
A porous composite material, hydroxyapatite technology, which is applied in medical science, tissue regeneration, prosthesis, etc. The effect of regulating mechanical properties, facilitating adhesion proliferation, and environment-friendly preparation process
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[0029] The embodiment of the present invention provides a preparation method of short peptide / silica / hydroxyapatite porous composite material, including:
[0030] S1: Dissolve the short peptide molecule in water, disperse it ultrasonically, adjust to a specified pH value, and place it at a certain temperature for assembly to obtain a solution containing short peptide self-assembly, that is, a short peptide solution.
[0031] In this step, the non-covalent interaction between the amphiphilic short peptide molecules is used to construct a short peptide self-assembly with mineralization activity. Specifically, dissolve the weighed short peptide powder in ultrapure water, disperse it in ultra-pure water, adjust it to a specified pH value and let it stand for assembly. Before using it in the next step, ensure that it is fully assembled. You can use an atomic force microscope or The transmission electron microscope observes its assembly. Through this step, a short peptide self-assembly ...
Example Embodiment
[0048] Example 1
[0049] First prepare 4mM amphiphilic short peptide solution and place it at room temperature for self-assembly; add 40μL of tetraethylorthosilicate and 1wt% polyvinyl alcohol to 1mL assembled amphiphilic short peptide solution, and shake well. After reacting at 25°C for 3 days to obtain short peptide / silica gel; after replacing the resulting gel with ultrapure water for 6 times, it was subjected to ice coagulation induction treatment with -80°C refrigerator, lyophilized and soaked in simulated body fluid The short peptide / silica / hydroxyapatite porous composite material 1 was obtained after 3 days.
Example Embodiment
[0050] Example 2
[0051] First prepare 10mM amphiphilic short peptide solution, and place it at room temperature for self-assembly; add 200μL of tetraethylorthosilicate and 2wt% sodium alginate to 1mL assembled amphiphilic short peptide solution, and shake well Then react at 25°C to obtain short peptide / silica hydrogel; replace the resulting gel with ultrapure water for 6 times, then conduct ice coagulation induction treatment with -196°C liquid nitrogen, and freeze-dry it in simulated body fluid Soak for 5 days to obtain short peptide / silica / hydroxyapatite porous composite material 2.
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