Application of porous titanium alloy in medical science as carrier

Abstract

The invention relates to an application of porous titanium alloy in medical science as a carrier. The application comprises the following steps: 1, winding and braiding medical titanium alloy wires to prepare porous titanium alloy; and 2, loading a drug to the surface or the porous structure of the porous titanium alloy through laser cladding, micro-arc oxidation, anodization, osmosis, an entrapping method, a solvent volatilization, a melting method or an adsorption balancing method. The porous titanium alloy can be used as an artificial joint, spinal column fusion, bone filling, bone restoration or bone transplantation material in order to realize surface activity increase, osteocyte growth and differentiation promotion, infection prevention, targeted administration and local administration effects. Compared with carriers in the prior art, the porous titanium alloy used as the carrier has the advantages of simplicity and easiness in operation, controllable structure, convenience in drug load, firm drug combination and low cost.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, in particular to a medical drug-loaded porous titanium alloy, which is mainly used in cardiovascular support, bone repair and bone support materials. Background technique

[0002] Titanium and titanium alloys have good mechanical properties, biocompatibility, corrosion resistance and excellent processing performance, and have become one of the most promising biomaterials. However, titanium and titanium alloys are biologically inert materials, which are surrounded by a layer of encapsulating fibrous membrane after implantation, making it difficult to form a firm combination with biological tissues. Therefore, it is of great significance to research and develop bio-titanium alloy materials that can not only give full play to the excellent properties of titanium and titanium alloys, but also have biological activity. Pores in medical materials can provide channels for bone cell growth and body f...

Examples

Embodiment 1

[0027] The raw material is medical TA1 titanium wire with a diameter of 0.05mm, which is made into porous titanium by winding weaving method. The average pore size of porous titanium is 0.1mm, the porosity is 30%, the strength is 50MPa, and the elastic modulus is 6GPa. The micro-arc oxidation method is used to generate a hydroxyapatite coating on the surface. The hydroxyapatite has excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 2

[0029] The raw material is medical TA1 titanium wire with a wire diameter of 0.2mm, which is made of porous titanium by winding weaving method. The average pore size of porous titanium is 0.3mm, the porosity is 50%, the strength is 30MPa, and the elastic modulus is 3GPa. Titanium dioxide nanotubes are generated on the surface of titanium wires by using anodic oxidation method. The titanium dioxide nanotubes have excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 3

[0031] The raw material is medical TA1 titanium wire with a wire diameter of 0.4mm, which is made of porous titanium by winding weaving method. The average pore size of porous titanium is 0.4mm, the porosity is 60%, the strength is 20MPa, and the elastic modulus is 2GPa. The calcium phosphate bone cement paste is poured into the porous structure and then solidified. Calcium phosphate has excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

technical field

[0001] The invention belongs to the field of biomedical materials, in particular to a medical drug-loaded porous titanium alloy, which is mainly used in cardiovascular support, bone repair and bone support materials. Background technique

[0002] Titanium and titanium alloys have good mechanical properties, biocompatibility, corrosion resistance and excellent processing performance, and have become one of the most promising biomaterials. However, titanium and titanium alloys are biologically inert materials, which are surrounded by a layer of encapsulating fibrous membrane after implantation, making it difficult to form a firm combination with biological tissues. Therefore, it is of great significance to research and develop bio-titanium alloy materials that can not only give full play to the excellent properties of titanium and titanium alloys, but also have biological activity. Pores in medical materials can provide channels for bone cell growth and body f...

Examples

Embodiment 1

[0027] The raw material is medical TA1 titanium wire with a diameter of 0.05mm, which is made into porous titanium by winding weaving method. The average pore size of porous titanium is 0.1mm, the porosity is 30%, the strength is 50MPa, and the elastic modulus is 6GPa. The micro-arc oxidation method is used to generate a hydroxyapatite coating on the surface. The hydroxyapatite has excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 2

[0029] The raw material is medical TA1 titanium wire with a wire diameter of 0.2mm, which is made of porous titanium by winding weaving method. The average pore size of porous titanium is 0.3mm, the porosity is 50%, the strength is 30MPa, and the elastic modulus is 3GPa. Titanium dioxide nanotubes are generated on the surface of titanium wires by using anodic oxidation method. The titanium dioxide nanotubes have excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 3

[0031] The raw material is medical TA1 titanium wire with a wire diameter of 0.4mm, which is made of porous titanium by winding weaving method. The average pore size of porous titanium is 0.4mm, the porosity is 60%, the strength is 20MPa, and the elastic modulus is 2GPa. The calcium phosphate bone cement paste is poured into the porous structure and then solidified. Calcium phosphate has excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.